|
rs1042522
|
|
Brain Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
We suggest that TP53 Pro47Ser and Arg72Pro polymorphisms and DNA hypermethylation are involved in susceptibility for developing extra-axial brain tumors.
|
19224462 |
2009 |
|
rs1042522
|
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
We studied whether the NAMPT rs1319501, AKT1 rs3730358, p53 rs1042522, Mdm2 rs2279744 or eNOS rs1799983 SNP:s linked to NAMPT and Akt signaling associate with risk of myocardial infarction (MI).
|
22251423 |
2012 |
|
rs1042522
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
We pooled data from four breast cancer cohorts within the Breast Cancer Association Consortium for which both TP53 R72P and MDM2 SNP309 were genotyped and follow-up was available (n = 3,749).
|
20021639 |
2009 |
|
rs1042522
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We pooled data from four breast cancer cohorts within the Breast Cancer Association Consortium for which both TP53 R72P and MDM2 SNP309 were genotyped and follow-up was available (n = 3,749).
|
20021639 |
2009 |
|
rs1042522
|
|
Endometriosis
|
|
0.060 |
GeneticVariation
|
BEFREE |
We performed this meta-analysis to estimate the association between p53 Arg72Pro</span> polymorphism and endometriosis.
|
22258307 |
2012 |
|
rs1042522
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
We performed a meta-analysis to evaluate the relationship between TP53 Arg72Pro polymorphism and lung cancer susceptibility basing on 15,647 lung cancer patients and 14,391 controls from 36 published literatures.
|
23595658 |
2013 |
|
rs1042522
|
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
We performed a meta-analysis to evaluate the relationship between TP53 Arg72Pro polymorphism and lung cancer susceptibility basing on 15,647 lung cancer patients and 14,391 controls from 36 published literatures.
|
23595658 |
2013 |
|
rs1042522
|
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
We performed a meta-analysis to evaluate the relationship between TP53 Arg72Pro polymorphism and lung cancer susceptibility basing on 15,647 lung cancer patients and 14,391 controls from 36 published literatures.
|
23595658 |
2013 |
|
rs1042522
|
|
Indian childhood cirrhosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We performed a case-control association study to evaluate the association between common polymorphisms in MTHFR (C677T and A1298C) and the Arg72Pro polymorphism in the p53 gene and the risk for cervical intraepithelial neoplasia (CIN) or invasive cervical cancer (ICC) in Mexican HPV-infected women.
|
24474455 |
2014 |
|
rs1042522
|
|
Intrahepatic Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We performed a case-control association study to evaluate the association between common polymorphisms in MTHFR (C677T and A1298C) and the Arg72Pro polymorphism in the p53 gene and the risk for cervical intraepithelial neoplasia (CIN) or invasive cervical cancer (ICC) in Mexican HPV-infected women.
|
24474455 |
2014 |
|
rs1042522
|
|
Infiltrating Cervical Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We performed a case-control association study to evaluate the association between common polymorphisms in MTHFR (C677T and A1298C) and the Arg72Pro polymorphism in the p53 gene and the risk for cervical intraepithelial neoplasia (CIN) or invasive cervical cancer (ICC) in Mexican HPV-infected women.
|
24474455 |
2014 |
|
rs1042522
|
|
Lupus Erythematosus, Systemic
|
|
0.030 |
GeneticVariation
|
BEFREE |
We investigated the frequency of the p53 Arg72Pro genotype in patients with SLE (n = 155) and in controls (n = 150) in Poland.
|
18250140 |
2008 |
|
rs1042522
|
|
Mammary Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
We investigated the effects of the germ-line single nucleotide polymorphisms TP53 R72P (215G>C) and MDM2 SNP309 (-410T>G), and p53 protein expression in breast tumors on survival.
|
20021639 |
2009 |
|
rs1042522
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the association between genetic variation in the promoter region of MDM2 (c.-5+309G>T, rs2279744:g.G>T) and the coding region of TP53 (c.215G>C, rs1042522:g.G>C, designated Arg72Pro) and the risk of developing lung cancer.
|
16287156 |
2006 |
|
rs1042522
|
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the association between genetic variation in the promoter region of MDM2 (c.-5+309G>T, rs2279744:g.G>T) and the coding region of TP53 (c.215G>C, rs1042522:g.G>C, designated Arg72Pro) and the risk of developing lung cancer.
|
16287156 |
2006 |
|
rs1042522
|
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the association between genetic variation in the promoter region of MDM2 (c.-5+309G>T, rs2279744:g.G>T) and the coding region of TP53 (c.215G>C, rs1042522:g.G>C, designated Arg72Pro) and the risk of developing lung cancer.
|
16287156 |
2006 |
|
rs1042522
|
|
Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
We identified the presence of LOH at 17p13 and Pro72Arg polymorphism in tumor DNA.
|
12684657 |
2003 |
|
rs1042522
|
|
Fast acetylator due to N-acetyltransferase enzyme variant
|
|
0.010 |
GeneticVariation
|
BEFREE |
We identified 'less credible' associations (higher heterogeneity, lower statistical power, BFDP > 0.02) with a further four variants of four independent genes: MTHFR c.677C>T p.A222V (rs1801133), TP53 c.215C>G p.R72P (rs1042522), NQO1 c.559C>T p.P187S (rs1800566), and NAT1 alleles imputed as fast acetylator genotypes.
|
26451011 |
2016 |
|
rs1042522
|
|
Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
We here studied the association of rs1219648 in FGFR2 and rs1042522 in TP53 and their interaction in development of early onset sporadic breast cancer in Iranian Azeri population to evaluate epistatic effects on the risk of mammary neoplasia.
|
25292094 |
2014 |
|
rs1042522
|
|
Sporadic Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
We here studied the association of rs1219648 in FGFR2 and rs1042522 in TP53 and their interaction in development of early onset sporadic breast cancer in Iranian Azeri population to evaluate epistatic effects on the risk of mammary neoplasia.
|
25292094 |
2014 |
|
rs1042522
|
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
We have therefore identified TP53 R72P as a possible risk modifier for childhood ALL and the association of MDM2 with age at onset with sex effect suggests prenatal hormonal programming of childhood ALL susceptibility.
|
19837266 |
2009 |
|
rs1042522
|
|
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
We have selected three <i>p53</i> polymorphisms, rs1642785 (C > G), and rs9894946 (A > G), and rs1042522 (Pro72Arg; C > G) and assessed their association with obesity risk in the Saudi population.
|
31762593 |
2019 |
|
rs1042522
|
|
Carcinoma of bladder
|
|
0.080 |
GeneticVariation
|
BEFREE |
We have reported previously that the TP53 codon72 polymorphism (rs1042522) is associated with the incidence and invasiveness of bladder cancer in a Han Chinese population.
|
22178231 |
2013 |
|
rs1042522
|
|
Malignant neoplasm of urinary bladder
|
|
0.080 |
GeneticVariation
|
BEFREE |
We have reported previously that the TP53 codon72 polymorphism (rs1042522) is associated with the incidence and invasiveness of bladder cancer in a Han Chinese population.
|
22178231 |
2013 |
|
rs1042522
|
|
Bladder Neoplasm
|
|
0.080 |
GeneticVariation
|
BEFREE |
We have reported previously that the TP53 codon72 polymorphism (rs1042522) is associated with the incidence and invasiveness of bladder cancer in a Han Chinese population.
|
22178231 |
2013 |