|
rs1800629
|
|
Stomach Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The meta-analysis suggests that TNF-α rs1800629 polymorphism is associated with the increased risk of gastric cancer in Caucasians.
|
24142527 |
2014 |
|
rs1800629
|
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
A functional polymorphism, -308G>A (rs1800629), which is located in the promoter of TNFA gene, has been suggested to alter the production of TNF-α and influence cancer risk.
|
24072494 |
2014 |
|
rs1800629
|
|
Malignant neoplasm of stomach
|
|
0.040 |
GeneticVariation
|
BEFREE |
The meta-analysis suggests that TNF-α rs1800629 polymorphism is associated with the increased risk of gastric cancer in Caucasians.
|
24142527 |
2014 |
|
rs1800629
|
|
Primary malignant neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
A functional polymorphism, -308G>A (rs1800629), which is located in the promoter of TNFA gene, has been suggested to alter the production of TNF-α and influence cancer risk.
|
24072494 |
2014 |
|
rs1800629
|
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
A functional polymorphism, -308 G>A (rs1800629), which is located in the promoter of TNFA gene, has been suggested to alter the production of TNF-α and influence cancer risk.
|
23326309 |
2013 |
|
rs1800629
|
|
Primary malignant neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
A functional polymorphism, -308 G>A (rs1800629), which is located in the promoter of TNFA gene, has been suggested to alter the production of TNF-α and influence cancer risk.
|
23326309 |
2013 |
|
rs1800629
|
|
Malignant neoplasm of stomach
|
|
0.040 |
GeneticVariation
|
BEFREE |
Statistical analysis results showed significant association of SNPs rs9344, rs1799931, and rs1800629 with the risk of gastric cancer.
|
23072573 |
2013 |
|
rs1800629
|
|
Stomach Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Statistical analysis results showed significant association of SNPs rs9344, rs1799931, and rs1800629 with the risk of gastric cancer.
|
23072573 |
2013 |
|
rs1800629
|
|
Sepsis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The minor allele frequency of rs1800629 was significantly higher in severe sepsis patients than that in both healthy controls (P(adj) = 0.00046, odds ratio (OR)(adj) = 1.92) and sepsis patients (P(adj) = 0.002, OR(adj) = 1.56).
|
23029405 |
2012 |
|
rs1800629
|
|
Chronic Obstructive Airway Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Of these variants, four were significantly associated with COPD susceptibility in random effects meta-analysis, the GSTM1 null variant (OR 1.45, CI 1.09-1.92), rs1800470 in TGFB1 (0.73, CI 0.64-0.83), rs1800629 in TNF (OR 1.19, CI 1.01-1.40) and rs1799896 in SOD3 (OR 1.97, CI 1.24-3.13).
|
19933216 |
2010 |
|
rs1800629
|
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
Initially, association with T1D was seen for LT-alpha A1069G (intron A, p=0.011, rs909253) and TNF G(-308)A (p<1x10(-5), rs1800629), but no association was observed for TNF G(-238)A (rs361525).
|
17174749 |
2006 |
|
rs1800629
|
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our analysis indicated no significant correlation between TNF-α-308G/A polymorphism (rs1800629) and CRC risk.
|
30610785 |
2019 |
|
rs1800629
|
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
The association of <i>TNF</i>-α <b>-</b>308 G>A (rs1800629) single-nucleotide polymorphism (SNP) with CRC risk has been investigated by many studies but the results are inconclusive.
|
30509964 |
2019 |
|
rs1800629
|
|
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
These results indicate that higher level of serum TNF-α increases risk of CHD, while TNF-α rs1800629 A allele might contribute to higher risk for CHD due to the increase in TNF-α expression.
|
31324728 |
2019 |
|
rs1800629
|
|
Lupus Erythematosus, Systemic
|
|
0.030 |
GeneticVariation
|
BEFREE |
Previous studies have investigated the association of TNF-α-238G/A (rs361525) and -308G/A (rs1800629) polymorphisms with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
|
30916218 |
2019 |
|
rs1800629
|
|
Ankylosing spondylitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
While <i>TNF</i>-308 (rs1800629) AA/GA, <i>IL17A</i> (rs2275913) AA/GA, and <i>IL17F</i> (rs763780) CC/TC genotype frequencies were associated, in the dominance inheritance model, with SpA and AS, regardless of gender, the presence of <i>HLA-B27</i>, <i>TNF</i>-238 (rs361525) GA/AA, <i>IL17A</i> (rs2275913) AA/GA, and <i>IL17F</i> (rs763780) genotypes was associated with PsA.
|
29849482 |
2018 |
|
rs1800629
|
|
Ankylosing spondylitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We replicated associations between AS and the polymorphisms in TNF (rs1800629), TNFRSF1A (rs4149570), and IL23R (rs11209026).
|
30208882 |
2018 |
|
rs1800629
|
|
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Promoter variants of TNF-α rs1800629 and IL-10 rs1800871 are independently associated with the susceptibility of coronary artery disease in north Indian.
|
29734056 |
2018 |
|
rs1800629
|
|
Ankylosing spondylitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
For rs1800629, the A allele was also linked to reduced risk of AS (p < 0.0001, OR = 0.54, 95% CI = 0.39-0.74).
|
29230494 |
2018 |
|
rs1800629
|
|
Lupus Erythematosus, Systemic
|
|
0.030 |
GeneticVariation
|
BEFREE |
An association between SLE and the rs1800629 polymorphism was established under the allelic model (allele A vs. allele G; odds ratios [OR] = 2.317), the dominant model (GA+AA vs. GG; OR = 3.214), and the overdominant model (GA vs. AA+GG; OR = 3.494).
|
29298134 |
2018 |
|
rs1800629
|
|
Metabolic Syndrome X
|
|
0.030 |
GeneticVariation
|
BEFREE |
The influence of the <i>TNFα</i> rs1800629 polymorphism on some inflammatory biomarkers in 45-60-year-old women with metabolic syndrome.
|
30383538 |
2018 |
|
rs1800629
|
|
Degenerative polyarthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
In conclusion, TNF-α rs1800629 polymorphism confers susceptibility to OA, especially among Asians.
|
29846433 |
2018 |
|
rs1800629
|
|
Degenerative polyarthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The purpose of the present case-control study was to investigate a possible association of four cytokine single nucleotide polymorphisms (SNPs), IL-4R -3223C>T (rs2057768), IL-8 -251T>A (rs4073), IL-10 -1082A>G (rs1800896) and TNF -A-308G>A (rs1800629) with OA susceptibility.
|
30186498 |
2018 |
|
rs1800629
|
|
Lupus Erythematosus, Systemic
|
|
0.030 |
GeneticVariation
|
BEFREE |
The TNF -238G/A (rs361525) and -308G/A (rs1800629) polymorphisms have consistently been associated with systemic lupus erythematosus (SLE) in several populations; however, these findings have not been verified in all populations.
|
29611038 |
2018 |
|
rs1800629
|
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
The results also showed a significant association between rs1800629 and an IBD-associated CRC population (heterozygous model: OR 4.335, 95% CI 2.329-8.069, P < 0.001; homozygous model: OR 11.5, 95% CI 2.498-52.592, P = 0.002; dominant model: OR 4.986, 95% CI 2.754-9.026, P < 0.001; recessive model: OR 7.208, 95% CI 1.588-32.72, P = 0.01).
|
28243990 |
2017 |