|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Nevertheless, we could not replicate the association of rs1344706 with schizophrenia</span>.
|
29112096 |
2018 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The biological function of ZNF804A rs1344706, the first genome-wide supported risk variant of schizophrenia, remains largely unknown.
|
28078547 |
2018 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The homozygous ZNF804A rs1344706 genotype (AA) conferred a high risk of sc</span>hizophrenia, and also exhibited significantly decreased resting functional coupling between the left hippocampus and right DLPFC (F(2,165) = 13.43, P < 0.001).
|
29611035 |
2018 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Neither univariate nor multivariate analyses showed any associations between indices of grey matter and rs1344706 variation in schizophrenia or healthy participants.
|
29247760 |
2018 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Three SNPs (rs1625579, rs1344706 and rs4765905) showed a consistent direction of effect with previous studies and the polygenic risk score constructed using the weighted sum of these three SNPs showed a significant association with Schizophrenia in this population (OR=3.78, p=0.005).
|
29599094 |
2018 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results elucidated the contribution of rs1344706 to functional connectivity within the brain network, and may have important implications for our understanding of this risk gene's role in functional dysconnectivity in schizophrenia.
|
29527501 |
2018 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Besides, positive association of rs1344706 with schizophrenia was observed in Northern Chinese (P = 0.005).
|
28120939 |
2017 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Put in perspective, ZNF804A rs1344706, not only had a significant main effect, but its SZ-specific effects were two orders of magnitude more widespread than that of CACNA1C rs1006737.
|
27790829 |
2017 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our result suggests that genetic variant rs1344706 might be associated with the development of schizophrenia in Asians.
|
28883732 |
2017 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Its intronic single-nucleotide polymorphism (SNP) rs1344706 is among one of the strongest susceptibility variants that have achieved genome-wide significance in genome-wide association studies (GWAS) for schizophrenia and has been widely and intensively studied.
|
28289284 |
2017 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Though the two SNPs did not remain significant if we applied multiple corrections, our analysis should be interpreted as a primary replication study with in prior hypothesis, and rs1344706 and rs1366842 might confer a small but detectable risk of schizophrenia (and bipolar disorder) in Asians.
|
26866941 |
2016 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results did not support the association of rs1344706 with schizophrenia in Han Chinese, and further association studies with large samples from other ethnic backgrounds and focus on more SNPs of ZNF804A are warranted.
|
26934312 |
2016 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Taken together, the disconnectivity of the lHF-PCC tract seems to be a plausible intermediate phenotype that links rs1344706 and schizophrenia.
|
26654932 |
2016 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs1344706 single nucleotide polymorphism within ZNF804A was among the first genetic variants found to be associated with schizophrenia.
|
26498712 |
2015 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our findings suggest that ZNF804A rs1344706 may aggravate the risk for schizophrenia by exerting its effects on cortical thickness, surface area, and cortical volume in these brain regions.
|
25921517 |
2015 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Analysing the groups separately (at p < 0.001, uncorrected), variation in rs1344706 showed effects on brain structure within the schizophrenia patients in several areas including the left and right inferior temporal, right supramarginal/superior temporal, right and left inferior frontal, left frontopolar, right and left dorsolateral/ventrolateral prefrontal cortices, and the right thalamus, as well as effects within the healthy controls in left lateral temporal, right anterior insula and left orbitofrontal cortical areas.
|
25065377 |
2015 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Here, we review literature recently published on ZNF804A, and analyze critical concepts related to the biology of ZNF804A and the role of rs1344706 in schizophrenia and bipolar disorder.
|
25522715 |
2015 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We verified that ZNF804A was significantly related to psychiatric diseases, and the association between ZNF804A rs1344706 and psychosis (schizophrenia and bipolar disorder) did not vary with disease or ethnicity.
|
25667193 |
2015 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs1344706 single nucleotide polymorphism within intron 2 of the ZNF804A gene is strongly associated with schizophrenia and bipolar disorder.
|
24636489 |
2014 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
No differences in ZNF804A-immunoreactive neurons were seen in schizophrenia or related to rs1344706 (P > .05).
|
25162540 |
2014 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The common variant rs1344706 within the zinc-finger protein gene ZNF804A has been strongly implicated in schizophrenia (SZ) susceptibility by a series of recent genetic association studies.
|
24424391 |
2014 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The current meta-analysis showed an association between rs1344706 and schizophrenia in Caucasian populations (P=0.028, OR=1.138, 95% CI: 1.014-1.278; P=0.004 for heterogeneity) and Asian populations (P=0.008, OR=1.092, 95% CI: 1.023-1.165; P=0.001 for heterogeneity), but not in other populations (P=0.286, OR=1.209, 95% CI: 0.853-1.714, P=0.120 for heterogeneity).
|
25526981 |
2014 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although this data does not preclude the possibility of other functional variants in ZNF804A, it provides evidence that the rs1344706 SZ risk allele is the cis-regulatory variant directly responsible for this allelic expression imbalance in adult cortex.
|
24315717 |
2014 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
In light of the strong DTI evidence for white matter microstructural abnormalities in schizophrenia, the current results implicate a potential mechanism for schizophrenia risk formation by ZNF804A rs1344706 genotype.
|
24685285 |
2014 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent evidence indicated that the ZNF804A (rs1344706) risk allele A is associated with better cognitive performance in patients with schizophrenia.
|
24078172 |
2014 |