|
rs1695
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of glutathione S-transferase (GST) genes including GSTT1 positive/null, GSTM1 positive/null, and GSTP1 A313G, and genes for reduced folate carrier 1 G80A (RFC1 G80A), methylenetetrahydrofolate reductase C677T (MTHFR C677T), and breast cancer resistant protein C421A (BCRP C421A) were determined for 26 patients by the polymerase chain reaction (PCR) method or by direct sequencing.
|
17180579 |
2007 |
|
rs1695
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, our meta-analysis suggests that GSTP1 Ile105Val polymorphism may increase susceptibility to breast cancer in Asian population.
|
20526737 |
2011 |
|
rs1695
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine the role of polymorphisms in GSTP1 (Ile105Val and Ala114Val), alone and in combination with ETS exposure, on atopy and asthma severity.
|
20858151 |
2010 |
|
rs1695
|
|
Prostate carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate this, we studied the association between prostate cancer and smoking, as well as the main and modifying effects of functional polymorphisms in genes that metabolize polycyclic aromatic hydrocarbons (CYP1A1 Ile(462)Val, microsomal epoxide hydrolase His(139)Arg) and detoxify reactive derivatives (GSTM1 null deletion, GSTT1 null deletion, GSTP1 Ile(105)Val and Ala(114)Val) using a family-based case-control design (439 prostate cancer cases and 479 brother controls).
|
16614120 |
2006 |
|
rs1695
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The GSTP1 Ile105Val polymorphism was not found to be significantly associated with urothelial cancer susceptibility but it may be associated with myelosuppressive adverse events in M-VAC chemotherapy.
|
17593093 |
2007 |
|
rs1695
|
|
Prostate carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Glutathione S-transferase P1 Ile105Val polymorphism, cigarette smoking and prostate cancer.
|
15542263 |
2004 |
|
rs1695
|
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
GSTP1 Ile105Val and hOGG1 Ser326Cys polymorphisms were not found to be risk factors of lung cancer in this study.
|
15896461 |
2005 |
|
rs1695
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested that there might be an association between GSTP1 Ile105Val polymorphism and lung cancer in the Chinese Han population.
|
22797821 |
2012 |
|
rs1695
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Reduced enzyme activity, due to carriage of the GSTM1 deletion or the GSTP1 Ile105Val Val allele, may therefore affect susceptibility to breast cancer and related conditions.
|
17624589 |
2008 |
|
rs1695
|
|
Prostate carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study we investigated the association of a number of polymorphic changes in antioxidant system genes (SNPs rs1050450 in the GPX1 gene, rs1695 and rs1138272 in the GSTP1 gene and rs4880 in the MnSOD gene) with the risk of prostate cancer.
|
24610081 |
2014 |
|
rs1695
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study we have addressed the possible role of the Ile105Val GSTP1 polymorphism in lung cancer susceptibility.
|
10334644 |
1999 |
|
rs1695
|
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of the analysis of gene-gene interactions of CYP1A1 MspI T6235C, GSTM1 present/null, GSTT1 present/null and GSTP1 Ile105Val polymorphisms in lung cancer risk indicate that these genes do not interact in lung cancer development.
|
23013535 |
2012 |
|
rs1695
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, there is no evidence showing a significant correlation between GSTP1 Ile105Val gene polymorphism and lung cancer risk in overall population, however stratified analysis by ethnicity, histology, gender and smoking status, it correlate with increased lung cancer susceptibility among Asians and smokers.
|
24566690 |
2014 |
|
rs1695
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
GSTP1 Ile(105)Val gene polymorphism influences its expression in blood, regardless of cancer disease.
|
21669193 |
2011 |
|
rs1695
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
For SNP rs1695 in the GSTP1 gene, a correlation with cancer disease stage was observed: a GG genotype is significantly more common in patients with PCa in the 3rd and 4th stage than 1st and 2nd (OR[95%CI] = 2.66[1.15-6.18], p = 0.02).
|
24610081 |
2014 |
|
rs1695
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
GSTP1 Ile105Val polymorphism might be associated with the risk of radiation pneumonitis among lung cancer patients in Chinese population: A prospective study.
|
29556330 |
2018 |
|
rs1695
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We genotyped Ile105Val and Ala114Val in the Multicenter Allergy Study cohort (85 children with asthma, 123 controls) and asthmatic children from Freiburg (n = 178).
|
16176403 |
2005 |
|
rs1695
|
|
Malignant neoplasm of prostate
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found no significant association between the GSTP1 I105V polymorphism and familial or sporadic PCa when compared to the control group [odds ratio (OR) =1.0 (0.74-1.37); P=0.58].
|
15527908 |
2004 |
|
rs1695
|
|
Malignant neoplasm of prostate
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, a study with the larger sample size is needed to further evaluate gene-environment interaction on GSTP1 Ile105Val polymorphisms and PCa risk.
|
23494181 |
2013 |
|
rs1695
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although the authors first determined whether genotypes of drug-metabolizing enzymes and transporters--glutathione S-transferase (GST) genes, GSTM1 positive/null, GSTT1 positive/null and GSTP1 A313G, methylenetetrahydrofolate reductase (MTHFR) C677T, reduced folate carrier 1 (RFC1) G80A, and breast cancer resistant protein (BCRP) C421A--were associated with hepatotoxicity for 24 patients, no significant difference was detected for genotype and allelic frequencies between the patients with and those without severe treatment-related hepatotoxicity.
|
20670164 |
2010 |
|
rs1695
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
GSTP1 Ile105Val was associated with increased lung function, reduced risk for lung cancer and tobacco-related cancer, and reduced all-cause mortality in the general population.
|
28739440 |
2017 |
|
rs1695
|
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
GSTP1 Ile105Val and hOGG1 Ser326Cys polymorphisms were not found to be risk factors of lung cancer in this study.
|
15896461 |
2005 |
|
rs1695
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Influence of GSTP1 I105V polymorphism on cumulative neuropathy and outcome of FOLFOX-4 treatment in Asian patients with colorectal carcinoma.
|
19922504 |
2010 |
|
rs1695
|
|
Prostate carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the GSTP1 Ile105Val genotype frequency in prostate cancer cases in the Kashmiri population, we designed a case-control study, in which 50 prostate cancer cases and 45 benign prostate hyperplasia cases were studied for GSTP1 Ile105Val polymorphism, compared to 80 controls taken from the general population, employing the PCR-RFLP technique.
|
22180037 |
2011 |
|
rs1695
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI = 1.02-1.92), the GSTM1 deletion polymorphism (OR = 1.38, 95% CI = 1.01-1.89), GSTP1 rs1695 (OR =1.48, 95% CI = 1.04-2.11), ERCC2 rs13181 (OR = 1.89, 95% CI = 1.28-2.78), and Chinese hamster 1 rs25487 (OR = 1.54, 95% CI = 1.12-2.13) were associated with lung cancer risk whereas the GSTT1 deletion polymorphism and XRCC3 rs861539 were not.
|
22525558 |
2012 |