|
rs1800795
|
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Among postmenopausal women not recently exposed to hormones, the AG/GG genotypes of rs1800797 (-596A>G) and the GC/CC genotypes of rs1800795 (-174G>C) significantly reduced risk of breast cancer among non-Hispanic white women [odds ratio (OR), 0.69; 95% confidence interval (95% CI), 0.48-1.00 and OR, 0.68; 95% CI, 0.47-0.99, respectively] and Hispanic/Native American women (OR, 0.48; 95% CI, 0.28-0.83 and OR, 0.44; 95% CI, 0.26-0.99, respectively).
|
17416766 |
2007 |
|
rs1800795
|
|
Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
There were no significant relationships between rs1800795 status and any patient or tumor characteristics, including estrogen receptor status.
|
28732081 |
2017 |
|
rs1800795
|
|
Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
The rs1800795 polymorphism in the promoter of the gene IL-6 can affect the transcription and expression of the gene, becoming a common target in association studies on tumors.
|
28296724 |
2017 |
|
rs1800795
|
|
Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
Associations between potentially functional IL6 (rs2069837 and rs1800795) and STAT3 (rs744166 and rs4796793) SNPs and clinical outcomes [progression-free survival (PFS), overall survival, and tumor response rate] were evaluated in mCRC patients receiving first-line FOLFIRI plus bevacizumab in two randomized phase III trials: TRIBE (n = 223, training cohort) and FIRE-3 (n = 288, validation cohort).
|
26839145 |
2016 |
|
rs1800795
|
|
Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
Most associations varied by recent aspirin/NSAID use: IL6 rs1800796 and rs1800795 polymorphisms were associated inversely with tumor mutations in the presence of aspirin/NSAIDs; POMC significantly reduced risk of Ki-ras-mutated tumors when aspirin/NSAIDs were not used; the TCF7L2 rs7903146 was associated with reduced risk of Ki-ras-mutated tumors in the presence of aspirin and increased risk in the absence of aspirin.
|
18992263 |
2009 |
|
rs1800795
|
|
Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
We assessed how these tumor markers were associated with use of anti-inflammatory drugs, polymorphisms in the IL6 genes (rs1800795 and rs1800796) and dietary antioxidants.
|
19452524 |
2009 |
|
rs1800795
|
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that IL-6 rs1800795, IL-18 rs1946518 and IL-18 rs187238 polymorphisms may confer susceptibility to TB, especially for Asians.
|
31676365 |
2020 |
|
rs1800795
|
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that IL-2 rs2069762, IL-4 rs2243250, IL-6 rs1800795, IL-8 rs4073, IL-10 rs1800871 and IL-10 rs1800896 polymorphisms may confer susceptibility to TB, especially for Asians.
|
31669382 |
2020 |
|
rs1800795
|
|
Coronary Artery Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Additionally, we found that carriers of the <i>C</i> allele of 174<i>G>C</i> (rs1800795) polymorphism have an increase in the risk of coronary artery disease under the hereditary models assessed in the study.
|
31338006 |
2019 |
|
rs1800795
|
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that IL-6 rs1800795, IL-8 rs4073, IL-10 rs1800871, IL-10 rs1800872 and IL-10 rs1800896 may confer susceptibility to TB.
|
31560754 |
2019 |
|
rs1800795
|
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
We observed a non-significant association between rs1800795 and overall cancer risk, while rs1800797 was found to have a false positive association with overall risk of cancer.
|
29842912 |
2018 |
|
rs1800795
|
|
Cervix carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Association of <i>IL-6</i> -174G>C (rs1800795) polymorphism with cervical cancer susceptibility.
|
30135142 |
2018 |
|
rs1800795
|
|
Malignant tumor of cervix
|
|
0.040 |
GeneticVariation
|
BEFREE |
Subgroup analysis indicated that rs1800795 was significantly associated with increased risk of cervical cancer, colorectal cancer, breast cancer, prostate cancer, lung cancer, glioma, non-Hodgkin's lymphoma and Hodgkin's lymphoma but not gastric cancer and multiple myeloma.
|
29552316 |
2018 |
|
rs1800795
|
|
Coronary Artery Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
The C allele of rs1800795 within IL-6 gene promoter, rs1800795-tobacco smoking and rs1800795-alcohol drinking interaction were all associated with increased CAD risk.
|
29889576 |
2018 |
|
rs1800795
|
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
GG genotypes of rs1800795 in IL-6 was also associated with occurrence of tuberculosis in our patients with TA.
|
28438554 |
2018 |
|
rs1800795
|
|
Malignant tumor of cervix
|
|
0.040 |
GeneticVariation
|
BEFREE |
Association of <i>IL-6</i> -174G>C (rs1800795) polymorphism with cervical cancer susceptibility.
|
30135142 |
2018 |
|
rs1800795
|
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
Simultaneously, rs1800795 and rs1800796 were associated with a significantly higher risk of cancer in Asia and Caucasian, rs1800797 was associated with a significantly risk of cancer in Caucasian but not in Asia.
|
29552316 |
2018 |
|
rs1800795
|
|
Cervix carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Subgroup analysis indicated that rs1800795 was significantly associated with increased risk of cervical cancer, colorectal cancer, breast cancer, prostate cancer, lung cancer, glioma, non-Hodgkin's lymphoma and Hodgkin's lymphoma but not gastric cancer and multiple myeloma.
|
29552316 |
2018 |
|
rs1800795
|
|
cervical cancer
|
|
0.040 |
GeneticVariation
|
BEFREE |
Subgroup analysis indicated that rs1800795 was significantly associated with increased risk of cervical cancer, colorectal cancer, breast cancer, prostate cancer, lung cancer, glioma, non-Hodgkin's lymphoma and Hodgkin's lymphoma but not gastric cancer and multiple myeloma.
|
29552316 |
2018 |
|
rs1800795
|
|
Primary malignant neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
Simultaneously, rs1800795 and rs1800796 were associated with a significantly higher risk of cancer in Asia and Caucasian, rs1800797 was associated with a significantly risk of cancer in Caucasian but not in Asia.
|
29552316 |
2018 |
|
rs1800795
|
|
Primary malignant neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
We observed a non-significant association between rs1800795 and overall cancer risk, while rs1800797 was found to have a false positive association with overall risk of cancer.
|
29842912 |
2018 |
|
rs1800795
|
|
cervical cancer
|
|
0.040 |
GeneticVariation
|
BEFREE |
Association of <i>IL-6</i> -174G>C (rs1800795) polymorphism with cervical cancer susceptibility.
|
30135142 |
2018 |
|
rs1800795
|
|
Cervix carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Haploview analysis demonstrated high linkage disequilibrium (LD) between rs2069845, rs2069840, rs1474348 and rs1800795, and 6-locus haplotype analysis identified GACCCA haplotype to be positively associated with increased CC, while GAGGGG haplotype was negatively associated with CC, thus suggesting a protective role for this haplotype in CC.
|
27722983 |
2017 |
|
rs1800795
|
|
Malignant tumor of cervix
|
|
0.040 |
GeneticVariation
|
BEFREE |
Haploview analysis demonstrated high linkage disequilibrium (LD) between rs2069845, rs2069840, rs1474348 and rs1800795, and 6-locus haplotype analysis identified GACCCA haplotype to be positively associated with increased CC, while GAGGGG haplotype was negatively associated with CC, thus suggesting a protective role for this haplotype in CC.
|
27722983 |
2017 |
|
rs1800795
|
|
Malignant tumor of cervix
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our results show that the C genotype of interleukin 6 rs1800795 is associated with higher cervical cancer risk.
|
27777338 |
2017 |