|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To evaluate the C677T and A1298C functional polymorphisms in the MTHFR gene and their associations with breast cancer risk, as well as the potential modifying effect by plasma folate status on the MTHFR-associated risk, a hospital-based case-control study was conducted on a Taiwanese population consisting of 146 histologically confirmed incident breast cancer cases and their 285 age-matched controls without a history of cancer.
|
16777985 |
2006 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for the low-activity C677T genotype (TT) may represent a genetic determinant increasing breast cancer risk.
|
16097444 |
2005 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In contrast, there was no statistically significant association between the risk of breast cancer and the MTHFR C677T genotype.
|
15736423 |
2005 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated independent and joint effects of B vitamin intake as well as two polymorphisms of a key one-carbon metabolizing gene [i.e., methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C] on breast cancer risk.
|
15735051 |
2005 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of p53 mutations and p53 codon 72, Her 2 codon 655 and MTHFR C677T polymorphisms with breast cancer in Northern Greece.
|
15837541 |
2005 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The common MTHFR C677T and TS enhancer region polymorphisms were not risk factors for breast cancer in this patient cohort nor were they associated with phenotypic features or with prognosis.
|
15510613 |
2004 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR C677T and A1298C polymorphisms are likely to play an important role in the susceptibility to breast cancer.
|
15004488 |
2004 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
After adjusting for age of menarche, parity, alcohol intake and total fat intake we observed reductions in odds ratios for breast cancer risk comparing the highest with the lowest quartiles of serum folate concentrations of 0.23 (95% confidence interval (CI) 0.09, 0.54) for the entire group, 0.27 (CI 0.09, 0.80) for the wild-type and 0.08 (CI 0.01, 0.52) for the heterozygous C677T genotype.
|
15110890 |
2004 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate.
|
14734703 |
2004 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Results of this study suggest that the MTHFR C677T polymorphisms may modify the association between dietary folate intake and breast cancer risk.
|
14973091 |
2004 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Therefore, we conclude that the MTHFR 677C>T polymorphism is not associated with individual susceptibility to breast cancer.
|
14572159 |
2003 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The low activity C677T (valine) genotype of MTHFR may increase the risk of early onset breast cancer.
|
12473175 |
2002 |