Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs9939609
rs9939609
FTO
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.790 GeneticVariation BEFREE The rs9939609 polymorphism in the FTO gene has recently been implicated as a risk factor for some types of cancer, such as breast, pancreatic, and prostate cancers. 29260910

2018

dbSNP: rs9939609
rs9939609
FTO
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.790 GeneticVariation BEFREE The study objective was to assess the prevalence of cardiovascular disease risk factors in patients treated for childhood cancer (<i>N</i> = 101) and to determine the involvement of clinical (cancer type and therapy) and/or genetic (<i>FTO</i> gene rs9939609 polymorphism) factors. 29675043

2018

dbSNP: rs9939609
rs9939609
FTO
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.790 GeneticVariation BEFREE Besides, in the subgroup analysis of ethnicity, our results indicated that rs9939609 polymorphism was significantly associated with cancer risk in Asians. 26931363

2017

dbSNP: rs9939609
rs9939609
FTO
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.790 GeneticVariation BEFREE However, <i>FTO</i> rs9939609 variant was associated with some types of cancer in the subgroup analysis. 28881622

2017

dbSNP: rs9939609
rs9939609
FTO
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.790 GeneticVariation BEFREE Variants (such as rs9939609) in the fat mass- and obesity-associated (FTO) gene have been associated with obesity, type 2 diabetes, some cancers, and alcohol consumption. 23771786

2013

dbSNP: rs9939609
rs9939609
FTO
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.790 GeneticVariation BEFREE Our meta-analysis indicated that there was no association between FTO rs9939609 polymorphism and the increased risk of c</span>ancer, although this polymorphism was marginally associated with pancreatic cancer. 22396042

2012

dbSNP: rs9939609
rs9939609
FTO
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.790 GeneticVariation BEFREE Among 22,799 individuals (44-74 years) in the population-based Malmö diet and cancer cohort that were genotyped for rs9939609 in FTO and had information on dietary intake (from a modified diet history method) and no history of diabetes, cancer or cardiovascular disease, 2255 deaths (including 1100 cancer and 674 cardiovascular deaths) occurred during 12.0 years of follow-up. 21179003

2011

dbSNP: rs9939609
rs9939609
FTO
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.790 GeneticVariation BEFREE The rs9939609 A allele, which was associated with higher BMI in the sample, was inversely associated with overall (odds ratio (OR) versus all controls  = 0.93; 95% confidence interval (CI): 0.85-1.02 p = 0.12 per allele) and low-grade (OR = 0.90; 0.81-0.99 p = 0.03 per allele) prostate cancer risk, but positively associated with high-grade cancer among cases (OR high- versus low-grade cancer  = 1.16; 0.99-1.37 p = 0.07 per allele). 20976066

2010

dbSNP: rs9939609
rs9939609
FTO
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.790 GeneticVariation BEFREE A cross-sectional study examined 4839 subjects in the population-based Malmö Diet and Cancer study with dietary data (from a modified diet history method) and information on the genetic variant FTO (rs9939609). 19726594

2009

dbSNP: rs1800625
rs1800625
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.720 GeneticVariation BEFREE CONCLUSIONS In conclusion, the RAGE rs1800625 polymorphism was associated with increased overall cancer risk in Asians in recessive genetic model. 31534114

2019

dbSNP: rs1800625
rs1800625
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.720 GeneticVariation BEFREE Therefore, we performed a systematic review to identify statistical evidence of the association between the 3 polymorphisms rs2070600 G/S (82G>S), rs1800624 T/A ( -374 T>A) and rs1800625C/T (-429 C>T) and the risk of cancer. 26011358

2015

dbSNP: rs1800625
rs1800625
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.720 GeneticVariation BEFREE We failed to get an effective conclusion about the association between the rs1800624 and rs1800625 polymorphisms and cancer risk in overall comparison. 26011358

2015

dbSNP: rs1042522
rs1042522
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 GeneticVariation BEFREE TP53 Arg72Pro (rs1042522 C > G) and miR-34b/c rs4938723 (T > C) polymorphisms have been known to modify cancer susceptibility. 31325764

2019

dbSNP: rs1042522
rs1042522
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 GeneticVariation BEFREE Single Nucleotide Polymorphisms (SNPs) of P53 Pro72Arg, MDM2 SNP309, P21 Ser31Arg, ER SNP594, HER2 Ile655Val, and FGFR2 rs2981582 have drawn attention as genetic factors associated with cancer risk. 31759353

2019

dbSNP: rs1042522
rs1042522
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 GeneticVariation BEFREE The <i>TP53</i> Arg72Pro (rs1042522 C>G) polymorphism has been reported to be associated with the risk of several types of adult cancers; however, its risk for pediatric cancers remains unclear. 31293648

2019

dbSNP: rs1042522
rs1042522
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 GeneticVariation BEFREE From other HPV-related malignancies a link between a functional SNP in the p53 gene (rs1042522, p.Arg72Pro) and a higher disease risk in the presence of HPV is documented. 30519324

2018

dbSNP: rs1042522
rs1042522
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 GeneticVariation BEFREE Previous studies have indicated that the <i>TP53</i> gene Arg72Pro (rs1042522 C>G) polymorphism is associated with susceptibility to various types of cancer. 28275206

2017

dbSNP: rs1042522
rs1042522
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 GeneticVariation BEFREE As ionizing radiation (IR) treatment is often used in cancer therapy, we sought to test the physiological effects of IR in mouse models of the p53 R72P polymorphism. 28594296

2017

dbSNP: rs1042522
rs1042522
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 GeneticVariation BEFREE Of them, a nonsynonymous polymorphism, Arg72Pro (rs1042522 C>G), has been most extensively studied for the association with cancer risk; however, few studies have investigated its effect on Wilms' tumor. 28260929

2017

dbSNP: rs1042522
rs1042522
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 GeneticVariation BEFREE Risk of cancer</span> specific mortality, cardiovascular mortality, and respiratory mortality were not associated with Arg72Pro genotype overall; however, in exploratory subgroup analyses, genotype-associated risks of malignant melanoma and diabetes were altered. 28336930

2017

dbSNP: rs1042522
rs1042522
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 GeneticVariation BEFREE Moreover, increased cancer risks were observed for the TP53 Arg72Pro polymorphism in patients with poorly differential status, clinical stage II, and without lymph node metastasis. 26619844

2016

dbSNP: rs1042522
rs1042522
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 GeneticVariation BEFREE Hence, this study explores the single and combined effects of cancer risk, age of onset and cancer type of three single nucleotide polymorphisms (SNPs)-TP53 Pro72Arg, MDM2 SNP285 and SNP309-already described as modifiers on TP53 mutation carriers but not properly investigated in LFS Suggestive patients. 26956143

2016

dbSNP: rs1042522
rs1042522
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 GeneticVariation BEFREE R72P associations with specific cancer risk, particularly hematological malignancies, have been conflicting. 25768405

2015

dbSNP: rs1042522
rs1042522
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 GeneticVariation BEFREE Single nucleotide polymorphisms (SNPs) of p53 rs1042522, MDM2 rs2279744 and p21 rs1801270, all in the p53 pathway, which plays a crucial role in DNA damage and genomic instability, were reported to be associated with cancer risk and pathologic characteristics. 26289323

2015

dbSNP: rs1042522
rs1042522
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 GeneticVariation BEFREE No Evidence of Association of the Arg72Pro p53 Gene Polymorphism with Cancer Risk in the Saudi Population: a Meta-Analysis. 26320432

2015