rs121913529
|
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Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
KRAS G12D point mutation plays an important role in the incidence of non-small-cell lung cancer (NSCLC) as well as colorectal cancer, pancreatic cancer and breast cancer.
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30876538 |
2019 |
rs121913529
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Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Importantly, FGTI-2734 inhibited the growth of xenografts derived from four patients with pancreatic cancer with mutant KRAS (2 G12D and 2 G12V) tumors.
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31227505 |
2019 |
rs121913529
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Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Oncogene-directed increased expression of Nrf2 is a new mechanism for the activation of the Nrf2 antioxidant program, and is evident in primary cells and tissues of mice expressing K-Ras(G12D) and B-Raf(V619E), and in human pancreatic cancer.
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21734707 |
2011 |
rs121913529
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Pancreatic carcinoma
|
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0.740 |
GeneticVariation
|
BEFREE |
We find that physiological levels of Kras(G12D) induce ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs), putative precursors to invasive pancreatic cancer.
|
14706336 |
2003 |
rs401681
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Pancreatic carcinoma
|
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0.740 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that T allele of CLPTM1L-telomerase reverse transcriptase rs401681 polymorphism is associated with an increased PC risk, especially among Chinese.
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25284078 |
2015 |
rs401681
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Pancreatic carcinoma
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|
0.740 |
GeneticVariation
|
BEFREE |
A small number of common susceptibility loci have been identified for pancreatic cancer, one of which is marked by rs401681 in the TERT-CLPTM1L gene region on chromosome 5p15.33.
|
25940397 |
2015 |
rs401681
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Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Our data suggests that the T allele of rs401681 in CLPTM1L-TERT locus predisposes its carriers to pancreatic cancer, and further research into the function of CLPTM1L-TERT locus and its potential biological mechanism association may be warranted.
|
24577890 |
2014 |
rs401681
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Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
These findings suggested that rs401681 C allele was a low-penetrance risk allele for the development of cancers of lung, bladder, prostate and basal cell carcinoma, but a potential protective allele for melanoma and pancreatic cancer.
|
23226346 |
2012 |
rs505922
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Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
This study provided evidence of SNP rs505922 C allele as a strong risk factor of cancer susceptibility, specifically for pancreatic cancer.
|
25656610 |
2015 |
rs505922
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Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
SNP rs505922, located within the first intron of the ABO gene, has been associated with the adenocarcinoma subtype of pancreatic cancer.
|
22642827 |
2012 |
rs505922
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Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Consistent with earlier reports showing a higher risk of PC for individuals with the non-O blood type, the previously reported protective allele (T) for rs505922 was found to be strongly correlated (r(2) = 0.96) with the O allele.
|
21306478 |
2011 |
rs505922
|
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Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28).
|
19648918 |
2009 |
rs3790844
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Pancreatic carcinoma
|
|
0.730 |
GeneticVariation
|
BEFREE |
In previously reported pancreatic cancer-associated SNPs, rs3790844 (NR5A2) showed a significant correlation with PDAC in our cohort.
|
28639428 |
2018 |
rs3790844
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Pancreatic carcinoma
|
|
0.730 |
GeneticVariation
|
BEFREE |
Our results showed that the rs3790843 (GA vs GG: OR=0.86, CI=0.76-0.98, <i>P</i>=0.992; GA+AA vs GG: OR=0.83, CI=0.73-0.94, <i>P</i>=0.950; A vs G: OR=0.85, CI=0.78-0.93, <i>P</i>=0.802), rs3790844 (CC vs TT: OR=0.65, CI=0.54-0.78, <i>P</i>=0.617; CC vs TT+CT: OR=0.73, CI=0.62-0.85, <i>P</i>=0.742; C vs T: OR=0.78, CI=0.73-0.84, <i>P</i>=0.555) and rs12029406 (TT vs CC: OR=0.73, CI=0.61-0.89, <i>P</i>=0.483; TT vs CC+CT: OR=0.78, CI=0.66-0.92, <i>P</i>=0.648; T vs C: OR=0.87, CI=0.79-0.95, <i>P</i>=0.837) polymorphisms were associated statistically with the risk of pancreatic cancer.
|
29785120 |
2018 |
rs3790844
|
|
Pancreatic carcinoma
|
|
0.730 |
GeneticVariation
|
BEFREE |
Our case-control study found that rs3790843 and rs3790844 in the NR5A2 gene are associated with pancreatic cancer risk in Japanese subjects.
|
26592175 |
2015 |
rs11655237
|
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Pancreatic carcinoma
|
|
0.720 |
GeneticVariation
|
BEFREE |
Long noncoding RNA LINC00673 has been widely explored for its role in the development and prognosis of many tumors, and 2 genome-wide association studies identified that LINC00673 rs11655237 was associated with susceptibility to pancreatic cancer.
|
30286619 |
2019 |
rs11655237
|
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Pancreatic carcinoma
|
|
0.720 |
GeneticVariation
|
BEFREE |
<b>Background:</b> Two genome-wide association studies (GWASs) identified LINC00673 rs11655237 was associated with susceptibility to pancreatic cancer.
|
31118802 |
2019 |
rs13303010
|
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Pancreatic carcinoma
|
|
0.710 |
GeneticVariation
|
BEFREE |
Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10<sup>-14</sup>), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10<sup>-10</sup>), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10<sup>-8</sup>), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10<sup>-8</sup>). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA.
|
29422604 |
2018 |
rs1517037
|
|
Pancreatic carcinoma
|
|
0.710 |
GeneticVariation
|
BEFREE |
Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10<sup>-14</sup>), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10<sup>-10</sup>), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10<sup>-8</sup>), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10<sup>-8</sup>). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA.
|
29422604 |
2018 |
rs1561927
|
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Pancreatic carcinoma
|
|
0.710 |
GeneticVariation
|
BEFREE |
The aim of our study was to investigate the contribution of two lncRNAs polymorphisms (rs1561927 and rs4759313 of PVT1 and HOTAIR, respectively) in PC susceptibility.
|
30475759 |
2019 |
rs2941471
|
|
Pancreatic carcinoma
|
|
0.710 |
GeneticVariation
|
BEFREE |
Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10<sup>-14</sup>), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10<sup>-10</sup>), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10<sup>-8</sup>), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10<sup>-8</sup>). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA.
|
29422604 |
2018 |
rs4795218
|
|
Pancreatic carcinoma
|
|
0.710 |
GeneticVariation
|
BEFREE |
Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10<sup>-14</sup>), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10<sup>-10</sup>), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10<sup>-8</sup>), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10<sup>-8</sup>). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA.
|
29422604 |
2018 |
rs13181
|
|
Pancreatic carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
In addition, haplotype analysis revealed that haplotype AGG, which comprised rs13181, rs3916874 and rs238415, was associated with a 1.401-fold increase in pancreatic cancer risk (p < 0.05).
|
29260835 |
2019 |
rs13181
|
|
Pancreatic carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
The present meta-analysis showed significant associations between deoxyribonucleic acid (DNA) repair gene (X-ray repair cross-complementing group 1 (XRCC1) Arg399GIn and Arg194Trp, excision repair cross complementation 1 (ERCC1) rs11615 and rs3212986, ERCC2 rs13181) polymorphisms and PC risk.
|
31393355 |
2019 |
rs13181
|
|
Pancreatic carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Association between ERCC2 Lys751Gln polymorphism and the risk of pancreatic cancer, especially among Asians: evidence from a meta-analysis.
|
28223548 |
2017 |