Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913529
rs121913529
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.740 GeneticVariation BEFREE KRAS G12D point mutation plays an important role in the incidence of non-small-cell lung cancer (NSCLC) as well as colorectal cancer, pancreatic cancer and breast cancer. 30876538

2019

dbSNP: rs121913529
rs121913529
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.740 GeneticVariation BEFREE Importantly, FGTI-2734 inhibited the growth of xenografts derived from four patients with pancreatic cancer with mutant KRAS (2 G12D and 2 G12V) tumors. 31227505

2019

dbSNP: rs121913529
rs121913529
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.740 GeneticVariation BEFREE Oncogene-directed increased expression of Nrf2 is a new mechanism for the activation of the Nrf2 antioxidant program, and is evident in primary cells and tissues of mice expressing K-Ras(G12D) and B-Raf(V619E), and in human pancreatic cancer. 21734707

2011

dbSNP: rs121913529
rs121913529
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.740 GeneticVariation BEFREE We find that physiological levels of Kras(G12D) induce ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs), putative precursors to invasive pancreatic cancer. 14706336

2003

dbSNP: rs401681
rs401681
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.740 GeneticVariation BEFREE This meta-analysis suggests that T allele of CLPTM1L-telomerase reverse transcriptase rs401681 polymorphism is associated with an increased PC risk, especially among Chinese. 25284078

2015

dbSNP: rs401681
rs401681
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.740 GeneticVariation BEFREE A small number of common susceptibility loci have been identified for pancreatic cancer, one of which is marked by rs401681 in the TERT-CLPTM1L gene region on chromosome 5p15.33. 25940397

2015

dbSNP: rs401681
rs401681
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.740 GeneticVariation BEFREE Our data suggests that the T allele of rs401681 in CLPTM1L-TERT locus predisposes its carriers to pancreatic cancer, and further research into the function of CLPTM1L-TERT locus and its potential biological mechanism association may be warranted. 24577890

2014

dbSNP: rs401681
rs401681
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.740 GeneticVariation BEFREE These findings suggested that rs401681 C allele was a low-penetrance risk allele for the development of cancers of lung, bladder, prostate and basal cell carcinoma, but a potential protective allele for melanoma and pancreatic cancer. 23226346

2012

dbSNP: rs505922
rs505922
ABO
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.740 GeneticVariation BEFREE This study provided evidence of SNP rs505922 C allele as a strong risk factor of cancer susceptibility, specifically for pancreatic cancer. 25656610

2015

dbSNP: rs505922
rs505922
ABO
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.740 GeneticVariation BEFREE SNP rs505922, located within the first intron of the ABO gene, has been associated with the adenocarcinoma subtype of pancreatic cancer. 22642827

2012

dbSNP: rs505922
rs505922
ABO
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.740 GeneticVariation BEFREE Consistent with earlier reports showing a higher risk of PC for individuals with the non-O blood type, the previously reported protective allele (T) for rs505922 was found to be strongly correlated (r(2) = 0.96) with the O allele. 21306478

2011

dbSNP: rs505922
rs505922
ABO
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.740 GeneticVariation BEFREE We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). 19648918

2009

dbSNP: rs3790844
rs3790844
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.730 GeneticVariation BEFREE In previously reported pancreatic cancer-associated SNPs, rs3790844 (NR5A2) showed a significant correlation with PDAC in our cohort. 28639428

2018

dbSNP: rs3790844
rs3790844
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.730 GeneticVariation BEFREE Our results showed that the rs3790843 (GA vs GG: OR=0.86, CI=0.76-0.98, <i>P</i>=0.992; GA+AA vs GG: OR=0.83, CI=0.73-0.94, <i>P</i>=0.950; A vs G: OR=0.85, CI=0.78-0.93, <i>P</i>=0.802), rs3790844 (CC vs TT: OR=0.65, CI=0.54-0.78, <i>P</i>=0.617; CC vs TT+CT: OR=0.73, CI=0.62-0.85, <i>P</i>=0.742; C vs T: OR=0.78, CI=0.73-0.84, <i>P</i>=0.555) and rs12029406 (TT vs CC: OR=0.73, CI=0.61-0.89, <i>P</i>=0.483; TT vs CC+CT: OR=0.78, CI=0.66-0.92, <i>P</i>=0.648; T vs C: OR=0.87, CI=0.79-0.95, <i>P</i>=0.837) polymorphisms were associated statistically with the risk of pancreatic cancer. 29785120

2018

dbSNP: rs3790844
rs3790844
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.730 GeneticVariation BEFREE Our case-control study found that rs3790843 and rs3790844 in the NR5A2 gene are associated with pancreatic cancer risk in Japanese subjects. 26592175

2015

dbSNP: rs11655237
rs11655237
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.720 GeneticVariation BEFREE Long noncoding RNA LINC00673 has been widely explored for its role in the development and prognosis of many tumors, and 2 genome-wide association studies identified that LINC00673 rs11655237 was associated with susceptibility to pancreatic cancer. 30286619

2019

dbSNP: rs11655237
rs11655237
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.720 GeneticVariation BEFREE <b>Background:</b> Two genome-wide association studies (GWASs) identified LINC00673 rs11655237 was associated with susceptibility to pancreatic cancer. 31118802

2019

dbSNP: rs13303010
rs13303010
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.710 GeneticVariation BEFREE Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10<sup>-14</sup>), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10<sup>-10</sup>), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10<sup>-8</sup>), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10<sup>-8</sup>). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. 29422604

2018

dbSNP: rs1517037
rs1517037
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.710 GeneticVariation BEFREE Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10<sup>-14</sup>), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10<sup>-10</sup>), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10<sup>-8</sup>), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10<sup>-8</sup>). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. 29422604

2018

dbSNP: rs1561927
rs1561927
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.710 GeneticVariation BEFREE The aim of our study was to investigate the contribution of two lncRNAs polymorphisms (rs1561927 and rs4759313 of PVT1 and HOTAIR, respectively) in PC susceptibility. 30475759

2019

dbSNP: rs2941471
rs2941471
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.710 GeneticVariation BEFREE Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10<sup>-14</sup>), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10<sup>-10</sup>), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10<sup>-8</sup>), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10<sup>-8</sup>). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. 29422604

2018

dbSNP: rs4795218
rs4795218
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.710 GeneticVariation BEFREE Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10<sup>-14</sup>), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10<sup>-10</sup>), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10<sup>-8</sup>), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10<sup>-8</sup>). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. 29422604

2018

dbSNP: rs13181
rs13181
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.060 GeneticVariation BEFREE In addition, haplotype analysis revealed that haplotype AGG, which comprised rs13181, rs3916874 and rs238415, was associated with a 1.401-fold increase in pancreatic cancer risk (p < 0.05). 29260835

2019

dbSNP: rs13181
rs13181
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.060 GeneticVariation BEFREE The present meta-analysis showed significant associations between deoxyribonucleic acid (DNA) repair gene (X-ray repair cross-complementing group 1 (XRCC1) Arg399GIn and Arg194Trp, excision repair cross complementation 1 (ERCC1) rs11615 and rs3212986, ERCC2 rs13181) polymorphisms and PC risk. 31393355

2019

dbSNP: rs13181
rs13181
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.060 GeneticVariation BEFREE Association between ERCC2 Lys751Gln polymorphism and the risk of pancreatic cancer, especially among Asians: evidence from a meta-analysis. 28223548

2017