rs864622007
|
|
Malignant neoplasm of prostate
|
|
0.830 |
GeneticVariation
|
BEFREE |
Our results indicate that the specific amino acid residue at position 701, its interaction with the backbone of Ser(778), and the steroidal 17alpha-hydroxyl group of the ligand are all important for the distinct transcriptional responses to progesterone and cortisol of AR mutants, including the prostate cancer mutant L701H.
|
20007693 |
2010 |
rs864622007
|
|
Malignant neoplasm of prostate
|
|
0.830 |
GeneticVariation
|
BEFREE |
This mutant AR contains two mutations (L701H and T877A) and was previously reported as a high-affinity cortisol/cortisone responsive AR (AR(ccr)) isolated from the androgen-independent human prostate cancer cell lines MDA PCa 2a and 2b (Zhao et al.Nature Med.2000, 6, 703-6).
|
11906285 |
2002 |
rs864622007
|
|
Malignant neoplasm of prostate
|
|
0.830 |
GeneticVariation
|
BEFREE |
The cortisol/cortisone-responsive AR (AR(ccr)) has two mutations (L701H and T877A) that were found in the MDA PCa human prostate cancer cell lines established from a castrated patient whose metastatic tumor exhibited androgen-independent growth.
|
11956172 |
2002 |
rs864622007
|
|
Malignant neoplasm of prostate
|
A |
0.830 |
GeneticVariation
|
CLINVAR |
|
|
|
rs864622007
|
|
Malignant neoplasm of prostate
|
|
0.830 |
GeneticVariation
|
UNIPROT |
|
|
|
rs10993994
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
This study demonstrated a significant association between the MSMB rs10993994 polymorphisms and PCa risk.
|
31773691 |
2019 |
rs10993994
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Overall, none associations between the allelic variants of rs10993994 polymorphisms with whole and PC aggressiveness were found.
|
30774776 |
2019 |
rs10993994
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our data indicated that MSMB gene rs10993994 polymorphism was associated with an increased risk of PC.
|
28212531 |
2017 |
rs10993994
|
|
Malignant neoplasm of prostate
|
T |
0.800 |
GeneticVariation
|
GWASDB |
Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.
|
24753544 |
2014 |
rs10993994
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Rs11672691 and rs10993994 were associated with both fatal and nonfatal PCa, while rs6465657, rs7127900, rs2735839, and rs13385191 were associated with nonfatal PCa only.
|
24411283 |
2014 |
rs10993994
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
BACKGROUND.With recent advances in high-throughput sequencing technologies, many prostate cancer risk loci have been identified, including rs10993994, a single nucleotide polymorphism (SNP) located near the MSMB gene.
|
24464504 |
2014 |
rs10993994
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Regardless of race and ethnicity or rs10993994 genotype, men with low blood levels of MSP have increased risk of prostate cancer.
|
23213189 |
2013 |
rs10993994
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Association of prostate cancer susceptibility variant (MSMB) rs10993994 with risk of spermatogenic failure.
|
23608167 |
2013 |
rs10993994
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
The rs10993994 genotype in the MSMB gene modifies the association between number of sexual partners and PCa risk.
|
24037734 |
2013 |
rs10993994
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
These data indicate that the increase in PC risk associated with rs10993994:C>T is likely mediated by the variant's effect on PSP94 expression; however, this effect does not extend to NCOA4 in the data presented here.
|
22887727 |
2013 |
rs10993994
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
PCa susceptibility was associated with TT genotype of SNP rs10993994 in this cohort of Scottish men and the increased risk of PCa was modified by serum enterolactone concentrations.
|
22733159 |
2012 |
rs10993994
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Six markers associated with early-onset prostate cancer [rs2171492 (7q32), rs6983561 (8q24), rs10993994 (10q11), rs4430796 (17q12), rs1799950 (17q21), and rs266849 (19q13)] were genotyped.
|
22144497 |
2012 |
rs10993994
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Cells with prostate cancer risk alleles at rs10993994 seem to cope more efficiently with DNA double strand breaks (less MN) in a shorter time (decreased MD index).
|
22677538 |
2012 |
rs10993994
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
After allowing for multiple testing, none of the SNPs examined were significantly associated with growth factor or hormone concentrations, and the SNP-prostate cancer associations did not differ by these concentrations, although 4 interactions were marginally significant (MSMB-rs10993994 with androstenedione (uncorrected P = 0.008); CTBP2-rs4962416 with IGFBP-3 (uncorrected P = 0.003); 11q13.2-rs12418451 with IGF-1 (uncorrected P = 0.006); and 11q13.2-rs10896449 with SHBG (uncorrected P = 0.005)).
|
22459122 |
2012 |
rs10993994
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Of note, rs7000448 is in strong linkage disequilibrium with rs10761581 in NCOA4, a SNP that has been implicated to be independently associated, with respect to the widely reported SNP rs10993994 in the nearby gene MSMB, with prostate cancer in men of European descent.
|
20717903 |
2011 |
rs10993994
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine.
|
20967219 |
2010 |
rs10993994
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.
|
20676098 |
2010 |
rs10993994
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
SNP rs10993994 is 2 bp upstream of the transcription initiation site of MSMB and was identified as an associated PrCa risk variant.
|
19997100 |
2010 |
rs10993994
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Genome-wide association studies (GWAS) have established a variant, rs10993994, on chromosome 10q11 as being associated with prostate cancer risk.
|
21085629 |
2010 |
rs10993994
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our results suggest a mechanism by which rs10993994 might predispose to prostate cancer and raise the possibility that genetic variation might need to be considered in interpreting the levels of these biomarkers.
|
20696662 |
2010 |