Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs13117307
rs13117307
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.730 GeneticVariation BEFREE We also observed associations of borderline significance with the TIPARP rs2665390 polymorphism, which was previously found to be associated with ovarian and breast cancer, and with the EXOC1 rs13117307 polymorphism, which has been linked to cervical cancer in a large study in a Chinese population. 28505207

2017

dbSNP: rs13117307
rs13117307
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.730 GeneticVariation BEFREE Role of rs13117307 single nuclear polymorphism in the risk of uterine cervical cancer from Polish population and its impact on exocyst complex component 1 expression. 28694212

2017

dbSNP: rs13117307
rs13117307
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.730 GeneticVariation BEFREE In this study, associations between invasive cervical cancer and four cervical cancer susceptibility loci (rs13117307 at 4q12, rs8067378 at 17q12, and rs4282438 and rs9277952 at 6p21.32) in the Han Chinese population were investigated in a Japanese population. 27193219

2016

dbSNP: rs13117307
rs13117307
CUI: C4048328
Disease: cervical cancer
cervical cancer
T 0.730 GeneticVariation GWASDB We identified strong evidence of associations between cervical cancer and two new loci: 4q12 (rs13117307, Pcombined, stringently matched=9.69×10(-9), per-allele odds ratio (OR)stringently matched=1.26) and 17q12 (rs8067378, Pcombined, stringently matched=2.00×10(-8), per-allele ORstringently matched=1.18). 23817570

2013

dbSNP: rs4282438
rs4282438
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.730 GeneticVariation BEFREE Compared with subjects carrying variant genotypes (GG/TG) and non-HPV16 infections, those carrying wild-type genotype (TT) of rs4282438 and HPV16 positive had a 5.22-fold increased risk of cervical cancer (95 % CI = 3.39-8.04). 26711785

2016

dbSNP: rs4282438
rs4282438
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.730 GeneticVariation BEFREE In this study, associations between invasive cervical cancer and four cervical cancer susceptibility loci (rs13117307 at 4q12, rs8067378 at 17q12, and rs4282438 and rs9277952 at 6p21.32) in the Han Chinese population were investigated in a Japanese population. 27193219

2016

dbSNP: rs4282438
rs4282438
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.730 GeneticVariation BEFREE No association was found with the two SNPs (rs4282438 or rs9277952) that were recently identified within the HLA-DP region in a cervical cancer GWAS in the Chinese population. 24743517

2014

dbSNP: rs4282438
rs4282438
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.730 GeneticVariation GWASDB We additionally replicated an association between HLA-DPB1 and HLA-DPB2 (HLA-DPB1/2) at 6p21.32 and cervical cancer (rs4282438, Pcombined, stringently matched=4.52×10(-27), per-allele ORstringently matched=0.75). 23817570

2013

dbSNP: rs2516448
rs2516448
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.720 GeneticVariation BEFREE The cGAS-STING pathway in innate immunity plays an important role in protecting against HPV infection.Chen et al. described that the rs2516448 SNP in the MHC locus may affect susceptibility to cervical cancer, a finding that we attempted to replicate in a Chinese population. 27705945

2016

dbSNP: rs2516448
rs2516448
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.720 GeneticVariation BEFREE The C allele of rs9272143 conferred protection against cervical cancer (odds ratio [OR] = 0.73, 95% confidence interval [CI] = 0.65-0.82; P = 1.6 × 10(-7)), which is associated with higher expression level of HLA-DRB1, whereas the T allele of rs2516448 increased the susceptibility to cervical cancer (OR = 1.33, 95% CI = 1.19-1.49; P = 5.8 × 10(-7)), with the same association shown with MICA-A5.1. 24403192

2014

dbSNP: rs2516448
rs2516448
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.720 GeneticVariation GWASDB Three independent loci in the major histocompatibility complex (MHC) region at 6p21.3 were associated with cervical cancer: the first is adjacent to the MHC class I polypeptide-related sequence A gene (MICA) (rs2516448; OR = 1.42, 95% CI = 1.31 to 1.54; P = 1.6×10(-18)); the second is between HLA-DRB1 and HLA-DQA1 (rs9272143; OR = 0.67, 95% CI = 0.62 to 0.72; P = 9.3×10(-24)); and the third is at HLA-DPB2 (rs3117027; OR=1.25, 95% CI = 1.15 to 1.35; P = 4.9×10(-8)). 23482656

2013

dbSNP: rs3117027
rs3117027
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.720 GeneticVariation BEFREE <i>Conclusion.</i> HLA-DP gene polymorphisms (HLA-DPB1⁎03:01, DPB1⁎04:02, DPB1⁎13:01, rs9277535, and rs3117027) were significantly associated with cervical cancer. 30009173

2018

dbSNP: rs3117027
rs3117027
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.720 GeneticVariation BEFREE No association was observed between rs3117027 and risk of cervical cancer. 24403192

2014

dbSNP: rs3117027
rs3117027
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.720 GeneticVariation GWASDB Three independent loci in the major histocompatibility complex (MHC) region at 6p21.3 were associated with cervical cancer: the first is adjacent to the MHC class I polypeptide-related sequence A gene (MICA) (rs2516448; OR = 1.42, 95% CI = 1.31 to 1.54; P = 1.6×10(-18)); the second is between HLA-DRB1 and HLA-DQA1 (rs9272143; OR = 0.67, 95% CI = 0.62 to 0.72; P = 9.3×10(-24)); and the third is at HLA-DPB2 (rs3117027; OR=1.25, 95% CI = 1.15 to 1.35; P = 4.9×10(-8)). 23482656

2013

dbSNP: rs8067378
rs8067378
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.720 GeneticVariation BEFREE Analysis of rs8067378 Polymorphism in the Risk of Uterine Cervical Cancer from a Polish Population and its Impact on Gasdermin B Expression. 28120299

2017

dbSNP: rs8067378
rs8067378
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.720 GeneticVariation BEFREE In this study, associations between invasive cervical cancer and four cervical cancer susceptibility loci (rs13117307 at 4q12, rs8067378 at 17q12, and rs4282438 and rs9277952 at 6p21.32) in the Han Chinese population were investigated in a Japanese population. 27193219

2016

dbSNP: rs8067378
rs8067378
CUI: C4048328
Disease: cervical cancer
cervical cancer
G 0.720 GeneticVariation GWASDB We identified strong evidence of associations between cervical cancer and two new loci: 4q12 (rs13117307, Pcombined, stringently matched=9.69×10(-9), per-allele odds ratio (OR)stringently matched=1.26) and 17q12 (rs8067378, Pcombined, stringently matched=2.00×10(-8), per-allele ORstringently matched=1.18). 23817570

2013

dbSNP: rs9272143
rs9272143
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.720 GeneticVariation BEFREE The C allele of rs9272143 conferred protection against cervical cancer (odds ratio [OR] = 0.73, 95% confidence interval [CI] = 0.65-0.82; P = 1.6 × 10(-7)), which is associated with higher expression level of HLA-DRB1, whereas the T allele of rs2516448 increased the susceptibility to cervical cancer (OR = 1.33, 95% CI = 1.19-1.49; P = 5.8 × 10(-7)), with the same association shown with MICA-A5.1. 24403192

2014

dbSNP: rs9272143
rs9272143
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.720 GeneticVariation BEFREE Variation in LD between the classic HLA loci, rs9272143 and rs67841474 between populations may explain the different associations of HLA-B*07 and DRB1*1501-DQB1*0602 with cervical cancer between studies. 24520070

2014

dbSNP: rs9272143
rs9272143
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.720 GeneticVariation GWASDB Three independent loci in the major histocompatibility complex (MHC) region at 6p21.3 were associated with cervical cancer: the first is adjacent to the MHC class I polypeptide-related sequence A gene (MICA) (rs2516448; OR = 1.42, 95% CI = 1.31 to 1.54; P = 1.6×10(-18)); the second is between HLA-DRB1 and HLA-DQA1 (rs9272143; OR = 0.67, 95% CI = 0.62 to 0.72; P = 9.3×10(-24)); and the third is at HLA-DPB2 (rs3117027; OR=1.25, 95% CI = 1.15 to 1.35; P = 4.9×10(-8)). 23482656

2013

dbSNP: rs9277535
rs9277535
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.720 GeneticVariation BEFREE <i>Conclusion.</i> HLA-DP gene polymorphisms (HLA-DPB1⁎03:01, DPB1⁎04:02, DPB1⁎13:01, rs9277535, and rs3117027) were significantly associated with cervical cancer. 30009173

2018

dbSNP: rs9277535
rs9277535
CUI: C4048328
Disease: cervical cancer
cervical cancer
A 0.720 GeneticVariation GWASDB A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12. 23817570

2013

dbSNP: rs9277535
rs9277535
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.720 GeneticVariation BEFREE These findings indicate that HLA-DP rs3077 and rs9277535 were candidate susceptibility markers for cervical cancer in Chinese females. 23428460

2013

dbSNP: rs9277952
rs9277952
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.720 GeneticVariation BEFREE In this study, associations between invasive cervical cancer and four cervical cancer susceptibility loci (rs13117307 at 4q12, rs8067378 at 17q12, and rs4282438 and rs9277952 at 6p21.32) in the Han Chinese population were investigated in a Japanese population. 27193219

2016

dbSNP: rs9277952
rs9277952
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.720 GeneticVariation BEFREE No association was found with the two SNPs (rs4282438 or rs9277952) that were recently identified within the HLA-DP region in a cervical cancer GWAS in the Chinese population. 24743517

2014