DisGeNET - a database of gene-disease associations

Source: GWASCAT

Gene: JAZF1 ×

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs864745

JAZF1

CUI:	C0011860
Disease:	Diabetes Mellitus, Non-Insulin-Dependent

Diabetes Mellitus, Non-Insulin-Dependent

0.890

GeneticVariation

GWASCAT

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.

28869590

2017

dbSNP:

rs864745

JAZF1

CUI:	C0011860
Disease:	Diabetes Mellitus, Non-Insulin-Dependent

Diabetes Mellitus, Non-Insulin-Dependent

0.890

GeneticVariation

GWASCAT

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

18372903

2008

dbSNP:

rs1635852

JAZF1

CUI:	C0036421
Disease:	Systemic Scleroderma

Systemic Scleroderma

0.800

GeneticVariation

GWASCAT

A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.

23740937

2013

dbSNP:

rs67250450

JAZF1

CUI:	C0003873
Disease:	Rheumatoid Arthritis

Rheumatoid Arthritis

0.800

GeneticVariation

GWASCAT

Genetics of rheumatoid arthritis contributes to biology and drug discovery.

24390342

2014

dbSNP:

rs849134

JAZF1

CUI:	C0011860
Disease:	Diabetes Mellitus, Non-Insulin-Dependent

Diabetes Mellitus, Non-Insulin-Dependent

0.800

GeneticVariation

GWASCAT

Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility.

27189021

2016

dbSNP:

rs849134

JAZF1

CUI:	C0011860
Disease:	Diabetes Mellitus, Non-Insulin-Dependent

Diabetes Mellitus, Non-Insulin-Dependent

0.800

GeneticVariation

GWASCAT

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.

20581827

2010

dbSNP:

rs849135

JAZF1

CUI:	C0011860
Disease:	Diabetes Mellitus, Non-Insulin-Dependent

Diabetes Mellitus, Non-Insulin-Dependent

0.800

GeneticVariation

GWASCAT

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.

30054458

2018

dbSNP:

rs849135

JAZF1

CUI:	C0011860
Disease:	Diabetes Mellitus, Non-Insulin-Dependent

Diabetes Mellitus, Non-Insulin-Dependent

0.800

GeneticVariation

GWASCAT

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

24509480

2014

dbSNP:

rs849135

JAZF1

CUI:	C0011860
Disease:	Diabetes Mellitus, Non-Insulin-Dependent

Diabetes Mellitus, Non-Insulin-Dependent

0.800

GeneticVariation

GWASCAT

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.

22885922

2012

dbSNP:

rs864745

JAZF1

CUI:	C0010346
Disease:	Crohn Disease

Crohn Disease

0.800

GeneticVariation

GWASCAT

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

23128233

2012

dbSNP:

rs10486567

JAZF1

CUI:	C0600139
Disease:	Prostate carcinoma

Prostate carcinoma

0.750

GeneticVariation

GWASCAT

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

29892016

2018

dbSNP:

rs10486567

JAZF1

CUI:	C0600139
Disease:	Prostate carcinoma

Prostate carcinoma

0.750

GeneticVariation

GWASCAT

A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.

26034056

2015

dbSNP:

rs1635852

JAZF1

CUI:	C0011860
Disease:	Diabetes Mellitus, Non-Insulin-Dependent

Diabetes Mellitus, Non-Insulin-Dependent

0.710

GeneticVariation

GWASCAT

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.

31118516

2019

dbSNP:

rs10225163

JAZF1

CUI:	C0003868
Disease:	Arthritis, Gouty

Arthritis, Gouty

0.700

GeneticVariation

GWASCAT

Gout and type 2 diabetes have a mutual inter-dependent effect on genetic risk factors and higher incidences.

22179738

2012

dbSNP:

rs10225163

JAZF1

CUI:	C0018099
Disease:	Gout

Gout

0.700

GeneticVariation

GWASCAT

Gout and type 2 diabetes have a mutual inter-dependent effect on genetic risk factors and higher incidences.

22179738

2012

dbSNP:

rs10245867

JAZF1

CUI:	C0013595
Disease:	Eczema

Eczema

0.700

GeneticVariation

GWASCAT

Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

30595370

2019

dbSNP:

rs10245867

JAZF1

CUI:	C0024141
Disease:	Lupus Erythematosus, Systemic

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASCAT

Transancestral mapping and genetic load in systemic lupus erythematosus.

28714469

2017

dbSNP:

rs10274928

JAZF1

CUI:	C0871470
Disease:	Systolic Pressure

Systolic Pressure

0.700

GeneticVariation

GWASCAT

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

30224653

2018

dbSNP:

rs10276381

JAZF1

CUI:	C0010346
Disease:	Crohn Disease

Crohn Disease

0.700

GeneticVariation

GWASCAT

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

26192919

2015

dbSNP:

rs1029534

JAZF1

CUI:	C0005890
Disease:	Body Height

Body Height

0.700

GeneticVariation

GWASCAT

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.

23563607

2013

dbSNP:

rs10486567

JAZF1

CUI:	C0201544
Disease:	Prostate specific antigen measurement

Prostate specific antigen measurement

0.700

GeneticVariation

GWASCAT

Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.

28139693

2017

dbSNP:

rs11495981

JAZF1

CUI:	C0341106
Disease:	Eosinophilic esophagitis

Eosinophilic esophagitis

0.700

GeneticVariation

GWASCAT

Genetic variants at the 16p13 locus confer risk for eosinophilic esophagitis.

29904099

2019

dbSNP:

rs11495981

JAZF1

CUI:	C0035242
Disease:	Respiratory Tract Diseases

Respiratory Tract Diseases

0.700

GeneticVariation

GWASCAT

Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

30595370

2019

dbSNP:

rs11973028

JAZF1

CUI:	C0919267
Disease:	ovarian neoplasm

ovarian neoplasm

0.700

GeneticVariation

GWASCAT

Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women.

30898391

2019

dbSNP:

rs11981911

JAZF1

CUI:	C1837461
Disease:	SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3

SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3

0.700

GeneticVariation

GWASCAT

The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

30019117

2018