Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800795
rs1800795
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.720 GeneticVariation GWASCAT A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin. 26545630

2016

dbSNP: rs1800795
rs1800795
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.720 GeneticVariation BEFREE In this case-control study, we aimed to investigate whether single nucleotide polymorphisms in the BIN1 (rs744373) and IL-6 (rs1800795) genes are associated with AD. 26733302

2016

dbSNP: rs1800795
rs1800795
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.720 GeneticVariation BEFREE Regression analysis revealed that the presence of both rs1801133 T and rs1800795 C alleles increased the odds of developing AD by 2.5 and VaD by 3.7-fold. 22015309

2012

dbSNP: rs2069837
rs2069837
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.720 GeneticVariation BEFREE Previous work has revealed a genetic association between Takayasu arteritis and a non-coding genetic variant in an enhancer region within <i>IL6</i> (rs2069837 A/G). 31315839

2019

dbSNP: rs2069837
rs2069837
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.720 GeneticVariation GWASCAT We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)). 25604533

2015

dbSNP: rs2069837
rs2069837
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.720 GeneticVariation BEFREE We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)). 25604533

2015

dbSNP: rs13306436
rs13306436
IL6
High density lipoprotein measurement
0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012

dbSNP: rs13306436
rs13306436
IL6
CUI: C0428472
Disease: Serum HDL cholesterol measurement
Serum HDL cholesterol measurement
0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012

dbSNP: rs13306436
rs13306436
IL6
CUI: C1445957
Disease: Serum total cholesterol measurement
Serum total cholesterol measurement
0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012

dbSNP: rs1474348
rs1474348
CUI: C0200638
Disease: Eosinophil count procedure
Eosinophil count procedure
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370

2019

dbSNP: rs2069837
rs2069837
CUI: C0023980
Disease: Longevity
Longevity
A 0.700 GeneticVariation GWASCAT A meta-analysis of genome-wide association studies identifies multiple longevity genes. 31413261

2019

dbSNP: rs2069837
rs2069837
CUI: C0023980
Disease: Longevity
Longevity
A 0.700 GeneticVariation GWASCAT Novel loci and pathways significantly associated with longevity. 26912274

2016

dbSNP: rs1800795
rs1800795
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE The C allele of rs1800795 was associated with PCa risk in the assessed population (OR (95% CI) = 1.45 (1.06-1.98)). 30345492

2019

dbSNP: rs1800795
rs1800795
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE Nevertheless, in the subgroup analysis by ethnicity, we identified that <i>IL-6</i>-rs1800795 polymorphism was associated with an increased risk of PCa for Caucasian individuals in dominant model (MM + MW vs. WW: OR = 1.245, 95%CI = 1.176-1.318, <i>P</i> < 0.001). 30854108

2019

dbSNP: rs1800795
rs1800795
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.070 GeneticVariation BEFREE The C allele of rs1800795 was associated with PCa risk in the assessed population (OR (95% CI) = 1.45 (1.06-1.98)). 30345492

2019

dbSNP: rs1800795
rs1800795
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.070 GeneticVariation BEFREE Nevertheless, in the subgroup analysis by ethnicity, we identified that <i>IL-6</i>-rs1800795 polymorphism was associated with an increased risk of PCa for Caucasian individuals in dominant model (MM + MW vs. WW: OR = 1.245, 95%CI = 1.176-1.318, <i>P</i> < 0.001). 30854108

2019

dbSNP: rs1800795
rs1800795
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE An association of the rs1800795 SNP of the IL-6 gene with T2D has been detected for the first time in Cretans. 29957071

2018

dbSNP: rs1800795
rs1800795
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE The Role of Interleukin-6 Polymorphism (rs1800795) in Prostate Cancer Development and Progression. 29848725

2018

dbSNP: rs1800795
rs1800795
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.070 GeneticVariation BEFREE The Role of Interleukin-6 Polymorphism (rs1800795) in Prostate Cancer Development and Progression. 29848725

2018

dbSNP: rs1800795
rs1800795
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE IL-6 genotypes of rs1800795 GC and rs1800796 GG might point to a relatively high risk for T2D patients suffering from PDR in a Chinese population and they were associated with elevation of IL-6 expression in both mRNA and protein. 28651253

2017

dbSNP: rs1800795
rs1800795
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE Overall estimates revealed no significant relationship between IL-6 rs1800795 polymorphism and prostate cancer risk in total analysis, but a risk-increasing effect of the polymorphism was detected in African-American subgroup under CC versus GG and CC versus GG + GC contrasts (OR 3.43, 95% CI 1.01-11.71; OR 3.51, 95% CI 1.04-11.82) after subgroup analysis by ethnicity.IL-6 rs1800795 polymorphism may enhance the susceptibility to prostate cancer in African-American men. 28296724

2017

dbSNP: rs1800795
rs1800795
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.070 GeneticVariation BEFREE Overall estimates revealed no significant relationship between IL-6 rs1800795 polymorphism and prostate cancer risk in total analysis, but a risk-increasing effect of the polymorphism was detected in African-American subgroup under CC versus GG and CC versus GG + GC contrasts (OR 3.43, 95% CI 1.01-11.71; OR 3.51, 95% CI 1.04-11.82) after subgroup analysis by ethnicity.IL-6 rs1800795 polymorphism may enhance the susceptibility to prostate cancer in African-American men. 28296724

2017

dbSNP: rs1800795
rs1800795
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE We investigated the role of two functional polymorphisms, IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796), in the development of prostate cancer. 26535651

2015

dbSNP: rs1800795
rs1800795
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.070 GeneticVariation BEFREE We investigated the role of two functional polymorphisms, IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796), in the development of prostate cancer. 26535651

2015

dbSNP: rs1800795
rs1800795
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE Interleukin-6 (IL-6)-597 A/G (rs1800797) & -174 G/C (rs1800795) gene polymorphisms in type 2 diabetes. 25222779

2014