|
rs1250550
|
|
Crohn Disease
|
|
0.820 |
GeneticVariation
|
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
|
rs1250550
|
|
Crohn Disease
|
G |
0.820 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
21102463 |
2010 |
|
rs1250544
|
|
Psoriasis
|
G |
0.810 |
GeneticVariation
|
GWASCAT |
Three of the shared loci are also genome-wide significantly associated with PS alone (10q22 at ZMIZ1, p(rs1250544) = 3.53 × 10(-8), 11q13 near PRDX5, p(rs694739) = 3.71 × 10(-09), 22q11 at YDJC, p(rs181359) = 8.02 × 10(-10)).
|
22482804 |
2012 |
|
rs1250550
|
|
Inflammatory Bowel Diseases
|
|
0.810 |
GeneticVariation
|
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
|
rs1250550
|
|
Inflammatory Bowel Diseases
|
|
0.810 |
GeneticVariation
|
GWASCAT |
We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 x 10(-9)), 22q12 (rs2412973, P = 1.55 x 10(-9)), 10q22 (rs1250550, P = 5.63 x 10(-9)), 2q37 (rs4676410, P = 3.64 x 10(-8)) and 19q13.11 (rs10500264, P = 4.26 x 10(-10)).
|
19915574 |
2009 |
|
rs12571751
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
G |
0.810 |
GeneticVariation
|
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
|
rs12571751
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
A |
0.810 |
GeneticVariation
|
GWASCAT |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
24509480 |
2014 |
|
rs12571751
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
A |
0.810 |
GeneticVariation
|
GWASCAT |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
rs11593576
|
|
Vitiligo
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.
|
20526339 |
2010 |
|
rs1250542
|
|
Multiple Sclerosis
|
A |
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
|
rs1250546
|
|
Inflammatory Bowel Diseases
|
A |
0.800 |
GeneticVariation
|
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
rs1250546
|
|
Psoriasis
|
A |
0.800 |
GeneticVariation
|
GWASCAT |
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
|
23143594 |
2012 |
|
rs1250550
|
|
Multiple Sclerosis
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
|
31407831 |
2019 |
|
rs1250550
|
|
Multiple Sclerosis
|
A |
0.800 |
GeneticVariation
|
GWASCAT |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
|
rs1250552
|
|
Celiac Disease
|
A |
0.800 |
GeneticVariation
|
GWASCAT |
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease.
|
22057235 |
2011 |
|
rs1250552
|
|
Celiac Disease
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Multiple common variants for celiac disease influencing immune gene expression.
|
20190752 |
2010 |
|
rs1250569
|
|
Crohn Disease
|
T |
0.720 |
GeneticVariation
|
GWASCAT |
We confirmed 6 previously reported loci in Caucasian: GPR35 at 2q37 (rs3749172; P = 5.30 × 10, odds ratio [OR] = 1.45), ZNF365 at 10q21 (rs224143; P = 2.20 × 10, OR = 1.38), ZMIZ1 at 10q22 (rs1250569; P = 3.05 × 10, OR = 1.30), NKX2-3 at 10q24 (rs4409764; P = 7.93 × 10, OR = 1.32), PTPN2 at 18p11 (rs514000; P = 9.00 × 10, OR = 1.33), and USP25 at 21q11 (rs2823256; P = 2.49 × 10, OR = 1.35), bringing the number of known CD loci (including 3 in the HLA) in Koreans to 15.
|
25489960 |
2015 |
|
rs704010
|
|
Breast Carcinoma
|
T |
0.720 |
GeneticVariation
|
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
rs704010
|
|
Breast Carcinoma
|
T |
0.720 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
|
25751625 |
2015 |
|
rs704010
|
|
Breast Carcinoma
|
T |
0.720 |
GeneticVariation
|
GWASCAT |
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
|
23535729 |
2013 |
|
rs704010
|
|
Breast Carcinoma
|
A |
0.720 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies five new breast cancer susceptibility loci.
|
20453838 |
2010 |
|
rs77911174
|
|
Prostate carcinoma
|
G |
0.710 |
GeneticVariation
|
GWASCAT |
We found 12 novel loci for PCa including rs1125927 (TMEM17, P = 3.95 × 10<sup>-16</sup>), rs73862213 (GATA2, P = 5.87 × 10<sup>-23</sup>), rs77911174 (ZMIZ1, P = 5.28 × 10<sup>-20</sup>), and rs138708 (SUN2, P = 1.13 × 10<sup>-15</sup>), seven of which had crucially low minor allele frequency in European population.
|
31562322 |
2019 |
|
rs10128264
|
|
Juvenile arthritis
|
C |
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
|
24709693 |
2014 |
|
rs11593576
|
|
Psoriasis
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis.
|
25854761 |
2015 |
|
rs1250544
|
|
Psoriasis vulgaris
|
G |
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.
|
26626624 |
2015 |