|
rs11549465
|
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation
|
BEFREE |
These results suggest that <i>HIF-1α</i> rs11549465 C>T polymorphism may predispose to cancer susceptibility.
|
31762805 |
2019 |
|
rs11549465
|
|
Malignant neoplasm of prostate
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our findings indicate that HIF1A rs11549465 polymorphism may not independently play a significant role in the occurrence of prostate cancer.
|
28415653 |
2017 |
|
rs11549465
|
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation
|
BEFREE |
Studies on HIF 1α C1772T (P582S) polymorphism revealed a genetic susceptibility to malignant tumors, however, the results were conflicting.
|
24576222 |
2014 |
|
rs11549465
|
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation
|
BEFREE |
In conclusion, our findings suggest that HIF1A Pro582Ser</span> polymorphism may contribute to the risk of digestive tract cancers, especially in Asian populations.
|
25117331 |
2014 |
|
rs11549465
|
|
Malignant neoplasm of prostate
|
|
0.060 |
GeneticVariation
|
BEFREE |
The HIF1A +1772 C>T (rs11549465) polymorphism was genotyped, using DNA isolated from peripheral blood, in 1490 male subjects (754 with prostate cancer and 736 controls cancer-free) through Real-Time PCR.
|
24090974 |
2014 |
|
rs11549465
|
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our findings suggest that the HIF-1α A588T polymorphism is significantly associated with higher cancer risk and the P582S polymorphism is significantly associated with pancreatic cancer risk.
|
24293391 |
2014 |
|
rs11549465
|
|
Malignant neoplasm of prostate
|
|
0.060 |
GeneticVariation
|
BEFREE |
The current findings suggest that HIF1A P582S polymorphism correlates with urinary cancers risk in Caucasian population, while A588T polymorphism may increase the risk of urinary cancers in Asian population and prostate cancer.
|
23723982 |
2013 |
|
rs11549465
|
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation
|
BEFREE |
This meta-analysis aims to derive a precise estimation of the association between a common polymorphism (C1772T; rs11549465 C>T) in the HIF-1α gene and susceptibility to GIT cancer.
|
24063654 |
2013 |
|
rs11549465
|
|
Malignant neoplasm of prostate
|
|
0.060 |
GeneticVariation
|
BEFREE |
No altered PCa risk was associated with the rs11549465 and rs2057482 polymorphism.
|
23042446 |
2012 |
|
rs11549465
|
|
Malignant neoplasm of prostate
|
|
0.060 |
GeneticVariation
|
BEFREE |
In previous studies, the C1772T (P582S) or the G1790A (A588T) polymorphisms of the HIF-1alpha gene have been identified in renal cell carcinoma, head and neck and esophageal squamous cell carcinomas as well as colorectal and prostate cancers.
|
18949419 |
2008 |
|
rs11549465
|
|
Malignant neoplasm of prostate
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our data suggest that homozygous HIF1A P582S mutation confers significant susceptibility to prostate cancer.
|
16998808 |
2007 |
|
rs11549465
|
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation
|
BEFREE |
The P582S HIF-1alpha is a stable variant and HIF-1alpha mutation is a mechanism for enhancing HIF-1alpha activity in human cancer.
|
15538748 |
2005 |
|
rs11549465
|
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
These results suggest that <i>HIF-1α</i> rs11549465 C>T polymorphism may predispose to cancer susceptibility.
|
31762805 |
2019 |
|
rs11549465
|
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our findings indicate that HIF1A rs11549465 polymorphism may not independently play a significant role in the occurrence of prostate cancer.
|
28415653 |
2017 |
|
rs11549465
|
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
The HIF1A +1772 C>T (rs11549465) polymorphism was genotyped, using DNA isolated from peripheral blood, in 1490 male subjects (754 with prostate cancer and 736 controls cancer-free) through Real-Time PCR.
|
24090974 |
2014 |
|
rs11549465
|
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our findings suggest that the HIF-1α A588T polymorphism is significantly associated with higher cancer risk and the P582S polymorphism is significantly associated with pancreatic cancer risk.
|
24293391 |
2014 |
|
rs11549465
|
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
Subgroup analysis by ethnicity suggested that HIF1A Pro582Ser polymorphism might increase an individual's susceptibility to digestive tract cancer in Asian populations.
|
25117331 |
2014 |
|
rs11549465
|
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
This meta-analysis aims to derive a precise estimation of the association between a common polymorphism (C1772T; rs11549465 C>T) in the HIF-1α gene and susceptibility to GIT cancer.
|
24063654 |
2013 |
|
rs11549465
|
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
The current findings suggest that HIF1A P582S polymorphism correlates with urinary cancers risk in Caucasian population, while A588T polymorphism may increase the risk of urinary cancers in Asian population and prostate cancer.
|
23723982 |
2013 |
|
rs11549465
|
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
No altered PCa risk was associated with the rs11549465 and rs2057482 polymorphism.
|
23042446 |
2012 |
|
rs11549465
|
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our data suggest that homozygous HIF1A P582S mutation confers significant susceptibility to prostate cancer.
|
16998808 |
2007 |
|
rs11549465
|
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
The P582S HIF-1alpha is a stable variant and HIF-1alpha mutation is a mechanism for enhancing HIF-1alpha activity in human cancer.
|
15538748 |
2005 |
|
rs11549465
|
|
Diabetic Nephropathy
|
|
0.030 |
GeneticVariation
|
BEFREE |
Recent work has shown that the <i>HIF-1A</i> Pro582Ser polymorphism is more resistant to hyperglycemia-mediated repression, thus protecting against the development of diabetic nephropathy.
|
31214621 |
2019 |
|
rs11549465
|
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
This meta-analysis was performed to assess the relationship between HIF-1α C1772T (rs11549465)/G1790A (rs11549467) gene polymorphism and RCC risk.
|
30539853 |
2018 |
|
rs11549465
|
|
Renal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
This meta-analysis was performed to assess the relationship between HIF-1α C1772T (rs11549465)/G1790A (rs11549467) gene polymorphism and RCC risk.
|
30539853 |
2018 |