rs1800795
|
|
Alzheimer's Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
In this case-control study, we aimed to investigate whether single nucleotide polymorphisms in the BIN1 (rs744373) and IL-6 (rs1800795) genes are associated with AD.
|
26733302 |
2016 |
rs1800795
|
|
Alzheimer's Disease
|
|
0.720 |
GeneticVariation
|
GWASCAT |
A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin.
|
26545630 |
2016 |
rs1800795
|
|
Alzheimer's Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
Regression analysis revealed that the presence of both rs1801133 T and rs1800795 C alleles increased the odds of developing AD by 2.5 and VaD by 3.7-fold.
|
22015309 |
2012 |
rs1800795
|
|
Malignant neoplasm of prostate
|
|
0.070 |
GeneticVariation
|
BEFREE |
Nevertheless, in the subgroup analysis by ethnicity, we identified that <i>IL-6</i>-rs1800795 polymorphism was associated with an increased risk of PCa for Caucasian individuals in dominant model (MM + MW vs. WW: OR = 1.245, 95%CI = 1.176-1.318, <i>P</i> < 0.001).
|
30854108 |
2019 |
rs1800795
|
|
Malignant neoplasm of prostate
|
|
0.070 |
GeneticVariation
|
BEFREE |
The C allele of rs1800795 was associated with PCa r</span>isk in the assessed population (OR (95% CI) = 1.45 (1.06-1.98)).
|
30345492 |
2019 |
rs1800795
|
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Nevertheless, in the subgroup analysis by ethnicity, we identified that <i>IL-6</i>-rs1800795 polymorphism was associated with an increased risk of PCa for Caucasian individuals in dominant model (MM + MW vs. WW: OR = 1.245, 95%CI = 1.176-1.318, <i>P</i> < 0.001).
|
30854108 |
2019 |
rs1800795
|
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
The C allele of rs1800795 was associated with PCa r</span>isk in the assessed population (OR (95% CI) = 1.45 (1.06-1.98)).
|
30345492 |
2019 |
rs1800795
|
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
The Role of Interleukin-6 Polymorphism (rs1800795) in Prostate Cancer Development and Progression.
|
29848725 |
2018 |
rs1800795
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
An association of the rs1800795 SNP of the IL-6 gene with T2D has been detected for the first time in Cretans.
|
29957071 |
2018 |
rs1800795
|
|
Malignant neoplasm of prostate
|
|
0.070 |
GeneticVariation
|
BEFREE |
The Role of Interleukin-6 Polymorphism (rs1800795) in Prostate Cancer Development and Progression.
|
29848725 |
2018 |
rs1800795
|
|
Malignant neoplasm of prostate
|
|
0.070 |
GeneticVariation
|
BEFREE |
Overall estimates revealed no significant relationship between IL-6 rs1800795 polymorphism and prostate cancer risk in total analysis, but a risk-increasing effect of the polymorphism was detected in African-American subgroup under CC versus GG and CC versus GG + GC contrasts (OR 3.43, 95% CI 1.01-11.71; OR 3.51, 95% CI 1.04-11.82) after subgroup analysis by ethnicity.IL-6 rs1800795 polymorphism may enhance the susceptibility to prostate cancer in African-American men.
|
28296724 |
2017 |
rs1800795
|
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Overall estimates revealed no significant relationship between IL-6 rs1800795 polymorphism and prostate cancer risk in total analysis, but a risk-increasing effect of the polymorphism was detected in African-American subgroup under CC versus GG and CC versus GG + GC contrasts (OR 3.43, 95% CI 1.01-11.71; OR 3.51, 95% CI 1.04-11.82) after subgroup analysis by ethnicity.IL-6 rs1800795 polymorphism may enhance the susceptibility to prostate cancer in African-American men.
|
28296724 |
2017 |
rs1800795
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
IL-6 genotypes of rs1800795 GC and rs1800796 GG might point to a relatively high risk for T2D patients suffering from PDR in a Chinese population and they were associated with elevation of IL-6 expression in both mRNA and protein.
|
28651253 |
2017 |
rs1800795
|
|
Malignant neoplasm of prostate
|
|
0.070 |
GeneticVariation
|
BEFREE |
We investigated the role of two functional polymorphisms, IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796), in the development of prostate cancer.
|
26535651 |
2015 |
rs1800795
|
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
We investigated the role of two functional polymorphisms, IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796), in the development of prostate cancer.
|
26535651 |
2015 |
rs1800795
|
|
Malignant neoplasm of prostate
|
|
0.070 |
GeneticVariation
|
BEFREE |
Direct sequencing of the PCR amplicon from genomic DNA was used for genotyping rs1800795 in all subjects [age-matched controls (N = 140) and prostate cancer patients (N = 164)].
|
24446297 |
2014 |
rs1800795
|
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Direct sequencing of the PCR amplicon from genomic DNA was used for genotyping rs1800795 in all subjects [age-matched controls (N = 140) and prostate cancer patients (N = 164)].
|
24446297 |
2014 |
rs1800795
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
Interleukin-6 (IL-6)-597 A/G (rs1800797) & -174 G/C (rs1800795) gene polymorphisms in type 2 diabetes.
|
25222779 |
2014 |
rs1800795
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
Recent studies identified a significant interaction between body mass index (BMI) and the rs1800795 polymorphism of the interleukin-6 gene that influences both IR and onset of type 2 diabetes mellitus, with obese individuals homozygous for the C allele demonstrating the highest level of IR and greatest risk for type 2 diabetes mellitus.
|
22075267 |
2012 |
rs1800795
|
|
Malignant neoplasm of prostate
|
|
0.070 |
GeneticVariation
|
BEFREE |
SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation.
|
19267250 |
2009 |
rs1800795
|
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation.
|
19267250 |
2009 |
rs1800795
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
This study examined a possible association of the G>C polymorphism at nucleotide -174 in the promoter region of the interleukin-6 (IL-6) gene (rs1800795) with the prevalence of diabetic complications in 235 patients with type 1 and 498 patients with type 2 diabetes.
|
19140096 |
2009 |
rs1800795
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
Several studies have investigated associations between the -174G>C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results.
|
18752089 |
2009 |
rs1800795
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G>C (rs1800795) and -573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal.
|
17003362 |
2006 |
rs1800795
|
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our findings indicated that IL-6 rs1800795 polymorphism was significantly associated with individual susceptibility to IS in Asians, but not in Caucasians.
|
31446341 |
2019 |