|
rs1800796
|
|
Stomach Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The stratified analysis showed that rs1</span>800796</span> G allele carriers (GG/CG) were associated with an increased risk of gastri</span>c cancer in the following subgroups: age >64 years old (OR<sub>adjusted</sub> = 1.67, 95% CI = 1.17-2.39), female (OR<sub>adjusted</sub> = 1.82, 95% CI = 1.09-3.05), positive for <i>H. pylori</i> infection (OR<sub>adjusted</sub> = 1.54, 95% CI = 1.07-2.22), non-cardiac gastric cancer (OR<sub>adjusted</sub> = 1.53, 95% CI = 1.15-2.04), stage T3-T4 tumor (OR<sub>adjusted</sub> = 1.41, 95% CI = 1.06-1.88), and gastric cancer with median to high differentiation (OR<sub>adjusted</sub> = 1.45, 95% CI = 1.08-1.96).
|
31312381 |
2019 |
|
rs1800796
|
|
Osteoporosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our results suggested that the C allele of rs1800796 and the C allele of rs2069849 of IL-6 gene interaction between rs1800796 and abdominal obesity were all associated with increased OST risk.
|
31301734 |
2019 |
|
rs1800796
|
|
Malignant neoplasm of stomach
|
|
0.040 |
GeneticVariation
|
BEFREE |
The stratified analysis showed that rs1</span>800796</span> G allele carriers (GG/CG) were associated with an increased risk of gastri</span>c cancer in the following subgroups: age >64 years old (OR<sub>adjusted</sub> = 1.67, 95% CI = 1.17-2.39), female (OR<sub>adjusted</sub> = 1.82, 95% CI = 1.09-3.05), positive for <i>H. pylori</i> infection (OR<sub>adjusted</sub> = 1.54, 95% CI = 1.07-2.22), non-cardiac gastric cancer (OR<sub>adjusted</sub> = 1.53, 95% CI = 1.15-2.04), stage T3-T4 tumor (OR<sub>adjusted</sub> = 1.41, 95% CI = 1.06-1.88), and gastric cancer with median to high differentiation (OR<sub>adjusted</sub> = 1.45, 95% CI = 1.08-1.96).
|
31312381 |
2019 |
|
rs1800796
|
|
Malignant neoplasm of stomach
|
|
0.040 |
GeneticVariation
|
BEFREE |
Further subgroup analyses based on ethnicities of participants revealed that the IL-4 rs2243250, IL-6 rs1800796 and IL-8 rs4073 polymorphisms were significantly associated with the risk of GC in Asians.
|
30071135 |
2018 |
|
rs1800796
|
|
Malignant neoplasm of stomach
|
|
0.040 |
GeneticVariation
|
BEFREE |
Furthermore, rs1800796 was significantly associated with increased risk of lung cancer, prostate cancer and colorectal cancer but not gastric cancer.
|
29552316 |
2018 |
|
rs1800796
|
|
Stomach Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Furthermore, rs1800796 was significantly associated with increased risk of lung cancer, prostate cancer and colorectal cancer but not gastric cancer.
|
29552316 |
2018 |
|
rs1800796
|
|
Stomach Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Further subgroup analyses based on ethnicities of participants revealed that the IL-4 rs2243250, IL-6 rs1800796 and IL-8 rs4073 polymorphisms were significantly associated with the risk of GC in Asians.
|
30071135 |
2018 |
|
rs1800796
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
IL-6 genotypes of rs1800795 GC and rs1800796 GG might point to a relatively high risk for T2D patients suffering from PDR in a Chinese population and they were associated with elevation of IL-6 expression in both mRNA and protein.
|
28651253 |
2017 |
|
rs1800796
|
|
Ischemic stroke
|
|
0.040 |
GeneticVariation
|
BEFREE |
Polymorphisms rs1800796 in IL6 gene and rs2383207 in CDKN2A/CDKN2B gene have significant associations with ischemic stroke in indigenous West African men.
|
28716248 |
2017 |
|
rs1800796
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
Overall, our results suggest that rs1800796 GG and rs1524107 CC homozygous genotypes may confer a greater risk for development of nephropathy in type 2 diabetes.
|
27500547 |
2016 |
|
rs1800796
|
|
Osteoporosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
In men, we detected significant interactions of IL-6 rs1800796 with LEPR rs1805096 and rs1892534 for FN and TH OST (all p < 0.05).
|
27401061 |
2016 |
|
rs1800796
|
|
Osteoporosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Using the meta-analysis approach, the present study is designed to provide a relatively comprehensive picture of the relationship between bone mineral density (BMD) or osteoporosis and polymorphisms in the promoter region of IL-6 (rs1800795 and rs1800796).
|
23760743 |
2014 |
|
rs1800796
|
|
Ischemic stroke
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our study suggests that IL-6 rs1800796 and IL-1B rs1864169 polymorphisms are associated with ischemic stroke risk in the Chinese population.
|
24782217 |
2014 |
|
rs1800796
|
|
Ischemic stroke
|
|
0.040 |
GeneticVariation
|
BEFREE |
In this study, we confirmed that the SNP of rs1800796 in the IL-6 gene is related to IS and the SAO subtype using different statistical approaches.
|
25325233 |
2014 |
|
rs1800796
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
The association between the interleukin-6 (IL-6) gene -572 C/G (rs1800796) polymorphism and type 2 diabetes mellitus (T2DM) risk remains controversial.
|
23289913 |
2013 |
|
rs1800796
|
|
Stomach Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Epidemiological studies have evaluated the associations between interleukin-6 (IL-6) gene -174 C/G (rs1800795) and -572 C/G (rs1800796) polymorphisms and gastric cancer (GC) risk, but results and conclusions remain controversial.
|
22711691 |
2012 |
|
rs1800796
|
|
Malignant neoplasm of stomach
|
|
0.040 |
GeneticVariation
|
BEFREE |
Epidemiological studies have evaluated the associations between interleukin-6 (IL-6) gene -174 C/G (rs1800795) and -572 C/G (rs1800796) polymorphisms and gastric cancer (GC) risk, but results and conclusions remain controversial.
|
22711691 |
2012 |
|
rs1800796
|
|
Ischemic stroke
|
|
0.040 |
GeneticVariation
|
BEFREE |
The association between single-nucleotide polymorphisms -174G/C (rs1800795) and -572G/C (rs1800796) in the interleukin-6 (IL-6) gene promoter region and ischemic heart disease (IHD)/ischemic stroke (IS) remains controversial and ambiguous.
|
21536090 |
2011 |
|
rs1800796
|
|
Osteoporosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
After adjusting for age, the IL6 -634G > C (rs1800796) allele showed association with osteoporosis (odds ratio (OR) for CC + CG = 2.51, p = 0.0047)), independent of statin use or smoking status.
|
19506792 |
2010 |
|
rs1800796
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G>C (rs1800795) and -573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal.
|
17003362 |
2006 |
|
rs1800796
|
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
Considering these promising results, IL-6 promoter including rs1800795, rs1800796 and rs1800797 may be a tumor marker for cancer therapy.
|
29552316 |
2018 |
|
rs1800796
|
|
Carcinoma of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
Furthermore, rs1800796 was significantly associated with increased risk of lung cancer, prostate cancer and colorectal cancer but not gastric cancer.
|
29552316 |
2018 |
|
rs1800796
|
|
Primary malignant neoplasm of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
Furthermore, rs1800796 was significantly associated with increased risk of lung cancer, prostate cancer and colorectal cancer but not gastric cancer.
|
29552316 |
2018 |
|
rs1800796
|
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Considering these promising results, IL-6 promoter including rs1800795, rs1800796 and rs1800797 may be a tumor marker for cancer therapy.
|
29552316 |
2018 |
|
rs1800796
|
|
Malignant neoplasm of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
Furthermore, rs1800796 was significantly associated with increased risk of lung cancer, prostate cancer and colorectal cancer but not gastric cancer.
|
29552316 |
2018 |