Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800797
rs1800797
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.020 GeneticVariation BEFREE Additionally, rs1800797 was significantly association with breast cancer, non-Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer. 29552316

2018

dbSNP: rs1800797
rs1800797
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.020 GeneticVariation BEFREE Considering these promising results, IL-6 promoter including rs1800795, rs1800796 and rs1800797</span> may be a tumor marker for cancer therapy. 29552316

2018

dbSNP: rs1800797
rs1800797
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.020 GeneticVariation BEFREE We observed a non-significant association between rs1800795 and overall cancer risk, while rs1800797 was found to have a false positive association with overall risk of cancer. 29842912

2018

dbSNP: rs1800797
rs1800797
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.020 GeneticVariation BEFREE Additionally, rs1800797 was significantly association with breast cancer, non-Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer. 29552316

2018

dbSNP: rs1800797
rs1800797
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.020 GeneticVariation BEFREE Considering these promising results, IL-6 promoter including rs1800795, rs1800796 and rs1800797</span> may be a tumor marker for cancer therapy. 29552316

2018

dbSNP: rs1800797
rs1800797
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.020 GeneticVariation BEFREE We observed a non-significant association between rs1800795 and overall cancer risk, while rs1800797 was found to have a false positive association with overall risk of cancer. 29842912

2018

dbSNP: rs1800797
rs1800797
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.020 GeneticVariation BEFREE Two alleles were significantly associated with disc degeneration: IL-6 rs1800797 and MMP-9 rs17576 and one proved to be protective: IL-6 rs1800795. 28551829

2017

dbSNP: rs1800797
rs1800797
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.020 GeneticVariation BEFREE The risk of DD was significantly higher in subjects with an allele G of IL6 SNPs rs1800795 (OR 1.45, 95% CI 1.07-1.96) and rs1800797</span> (OR 1.37, 95% CI 1.02-1.85) in the additive inheritance model. 22107760

2011

dbSNP: rs1800797
rs1800797
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.020 GeneticVariation BEFREE For knee OA the smallest P-value was seen for rs1800797 OR(Aallele)=1.055 (95%CI 0.98-1.12) P<0.18, no significant heterogeneity was observed (I(2)=0%, P<0.68). 20175976

2010

dbSNP: rs1800797
rs1800797
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.020 GeneticVariation BEFREE The objective of this study was to investigate the relationship of the IL-6 promoter variants G-597A, G-572C and G-174C (rs1800797, rs1800796 and rs1800795, respectively), which have been shown to affect both the transcription and secretion of IL-6, to symptomatic distal interphalangeal (DIP) osteoarthritis (OA). 18257935

2008

dbSNP: rs1800797
rs1800797
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.020 GeneticVariation BEFREE Among postmenopausal women not recently exposed to hormones, the AG/GG genotypes of rs1800797 (-596A>G) and the GC/CC genotypes of rs1800795 (-174G>C) significantly reduced risk of breast cancer among non-Hispanic white women [odds ratio (OR), 0.69; 95% confidence interval (95% CI), 0.48-1.00 and OR, 0.68; 95% CI, 0.47-0.99, respectively] and Hispanic/Native American women (OR, 0.48; 95% CI, 0.28-0.83 and OR, 0.44; 95% CI, 0.26-0.99, respectively). 17416766

2007

dbSNP: rs1800797
rs1800797
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.020 GeneticVariation BEFREE Among postmenopausal women not recently exposed to hormones, the AG/GG genotypes of rs1800797 (-596A>G) and the GC/CC genotypes of rs1800795 (-174G>C) significantly reduced risk of breast cancer among non-Hispanic white women [odds ratio (OR), 0.69; 95% confidence interval (95% CI), 0.48-1.00 and OR, 0.68; 95% CI, 0.47-0.99, respectively] and Hispanic/Native American women (OR, 0.48; 95% CI, 0.28-0.83 and OR, 0.44; 95% CI, 0.26-0.99, respectively). 17416766

2007

dbSNP: rs1800797
rs1800797
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.010 GeneticVariation BEFREE This meta-analysis indicated that IL-6 rs1800795, rs1800796 and rs1800797 played important roles in DN development while IL-6 rs2069837 and rs2069840 might not be related to DN. 31451183

2019

dbSNP: rs1800797
rs1800797
CUI: C0028754
Disease: Obesity
Obesity
0.010 GeneticVariation BEFREE Minor alleles of rs1800795 raised and rs1800797 reduced the risk of obesity, while rs1800796 and rs2069845 may not be associated. 31472475

2019

dbSNP: rs1800797
rs1800797
CUI: C0038354
Disease: Stomach Diseases
Stomach Diseases
0.010 GeneticVariation BEFREE In view of the involvement of the IL-6 law and the presence of H. pylori in the development of gastric diseases, the present study aimed to characterize the promoter-region polymorphism -597 (G/A) (rs1800797), -572 (C/G) (rs1800796), and -174 (G/C) (rs1800795) by PCR-RFLP in 375 gastric biopsy specimens from patients with peptic symptoms. 30525242

2019

dbSNP: rs1800797
rs1800797
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.010 GeneticVariation BEFREE Subgroup analyses of rs1800797 also suggested non-significant association and rs1800795 played a protective role in liver cancer. 29842912

2018

dbSNP: rs1800797
rs1800797
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma
0.010 GeneticVariation BEFREE Additionally, rs1800797 was significantly association with breast cancer, non-Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer. 29552316

2018

dbSNP: rs1800797
rs1800797
CUI: C0220630
Disease: Adult Liver Carcinoma
Adult Liver Carcinoma
0.010 GeneticVariation BEFREE Subgroup analyses of rs1800797 also suggested non-significant association and rs1800795 played a protective role in liver cancer. 29842912

2018

dbSNP: rs1800797
rs1800797
CUI: C0079744
Disease: Diffuse Large B-Cell Lymphoma
Diffuse Large B-Cell Lymphoma
0.010 GeneticVariation BEFREE Additionally, rs1800797 was significantly association with breast cancer, non-Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer. 29552316

2018

dbSNP: rs1800797
rs1800797
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.010 GeneticVariation BEFREE Considering these promising results, IL-6 promoter including rs1800795, rs1800796 and rs1800797 may be a tumor marker for cancer therapy. 29552316

2018

dbSNP: rs1800797
rs1800797
Liver and Intrahepatic Biliary Tract Carcinoma
0.010 GeneticVariation BEFREE Subgroup analyses of rs1800797 also suggested non-significant association and rs1800795 played a protective role in liver cancer. 29842912

2018

dbSNP: rs1800797
rs1800797
CUI: C1857276
Disease: Trichohepatoenteric Syndrome
Trichohepatoenteric Syndrome
0.010 GeneticVariation BEFREE This study investigated the frequency of interleukin 6 polymorphisms (rs1800795, rs1800796, and rs1800797) in individuals with DS and individuals without the syndrome. 28829905

2017

dbSNP: rs1800797
rs1800797
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.010 GeneticVariation BEFREE In view of this, the current study aimed to investigate the possible association of 5' promoter polymorphisms G-597A (rs1800797), G-572C (rs1800796) and G-174C (rs1800795) with the risk of SLE. 28530463

2017

dbSNP: rs1800797
rs1800797
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.010 GeneticVariation BEFREE Carriage of IL-6 rs1800796 G/G genotype, IL-6 rs1474358 C-allele, and IL-6 rs1800797 A-allele was more frequent in chronic HCV-infected patients than in HCC patients. 28340949

2017

dbSNP: rs1800797
rs1800797
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.010 GeneticVariation BEFREE This study investigated the frequency of interleukin 6 polymorphisms (rs1800795, rs1800796, and rs1800797) in individuals with DS and individuals without the syndrome. 28829905

2017