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rs429358
|
|
Alzheimer's Disease
|
|
0.890 |
GeneticVariation
|
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
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rs429358
|
|
Alzheimer's Disease
|
C |
0.890 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project.
|
31473137 |
2019 |
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rs429358
|
|
Alzheimer's Disease
|
|
0.890 |
GeneticVariation
|
GWASCAT |
Genetic heterogeneity of Alzheimer's disease in subjects with and without hypertension.
|
31055733 |
2019 |
|
rs429358
|
|
Alzheimer's Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
There was no interaction between rs9331896 in CLU and rs429358 (defining the ɛ4 allele) in APOE in predicting Alzheimer's disease or all dementia (P = 0.39 and P = 0.21).
|
29534716 |
2018 |
|
rs429358
|
|
Alzheimer's Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
APOE gene comprises of three alleles determined by two single nucleotide polymorphisms (rs429358 and rs7412) resulting in the protein isoforms, among which ApoE4 is a confirmed risk factor for Alzheimer's Disease.
|
29776682 |
2018 |
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rs429358
|
|
Alzheimer's Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
We applied our proposed method to explore the relation between the well-known AD risk SNP APOE rs429358 and three baseline brain imaging modalities (i.e., structural magnetic resonance imaging (MRI), fluorodeoxyglucose positron emission tomography (FDG-PET) and F-18 florbetapir PET scans amyloid imaging (AV45)) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database.
|
27277494 |
2016 |
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rs429358
|
|
Alzheimer's Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Subsequently, to evaluate comprehensively the APOE (apolipoprotein E) haplotype variants (E1/E2/E3/E4), the markers rs7412 and rs429358 were genotyped in 93 AD affected carriers of the E280A mutation.
|
26619808 |
2016 |
|
rs429358
|
|
Alzheimer's Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
The APOE rs429358 variation significantly influenced the brain network characteristics, affecting the activation of nodes as well as the connectivity of edges in aMCI subjects.The cholesterol metabolism pathway gene-based imaging genetics approach may provide new opportunities to understand the mechanisms underlying AD and suggested that APOE rs429358 is a core genetic variation that is associated with disease-related differences in brain function.
|
26985771 |
2016 |
|
rs429358
|
|
Alzheimer's Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Three SNPs [rs429358 in APOE: odds ratio (OR)=4.24, 95% confidence interval (CI)=3.01-5.96, P=1.23×10; rs2075650 in APOE: OR=3.57, 95% CI=2.51-5.06, P=1.23×10; and rs677909 in PICALM: OR=0.63, 95% CI=0.49-0.81, P=0.00036, log additive model] were significantly associated with AD susceptibility after correction for multiple testing.
|
22975751 |
2014 |
|
rs429358
|
|
Alzheimer's Disease
|
C |
0.890 |
GeneticVariation
|
GWASCAT |
APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.
|
23419831 |
2014 |
|
rs429358
|
|
Alzheimer's Disease
|
|
0.890 |
GeneticVariation
|
GWASCAT |
SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.
|
25027320 |
2014 |
|
rs429358
|
|
Alzheimer's Disease
|
|
0.890 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.
|
21123754 |
2011 |
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rs429358
|
|
Alzheimer's Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Apolipoprotein E (APOE) genotype (ε2/ε3/ε4: rs429358 ε4 allele; rs7412 ε2 allele) is strongly associated with both lipid levels and Alzheimer's disease.
|
21215387 |
2011 |
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rs429358
|
|
Alzheimer's Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
ApoE single nucleotide polymorphisms (SNPs) Cys112Arg (Epsilon-4), and Arg158Cys (Epsilon-2) have been implicated in cardiovascular and Alzheimer's disease, but their role in colorectal cancer (CRC) has not been extensively studied.
|
19455140 |
2009 |
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rs429358
|
|
Alzheimer's Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Here, we evaluate whether synthetic RNA/DNA oligonucleotides (chimeraplasts) can convert a dysfunctional gene, APOE4 (C, A and E, T, Cys112Arg), a risk factor for Alzheimer's disease and other neurological disorders, into wild-type APOE3.
|
15781970 |
2005 |
|
rs429358
|
|
Alzheimer's Disease
|
C |
0.890 |
GeneticVariation
|
CLINVAR |
|
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