rs10499194
|
|
Rheumatoid Arthritis
|
|
0.880 |
GeneticVariation
|
BEFREE |
Our data indicated that TNFAIP3 gene rs10499194, rs13207033 polymorphisms were associated with the decreased risk of RA.
|
27779104 |
2016 |
rs10499194
|
|
Rheumatoid Arthritis
|
|
0.880 |
GeneticVariation
|
BEFREE |
This study showed that carriers of the rs2230926 TG genotype or rs10499194 CT genotype had an increased risk for RA compared with those carrying the wild genotype (rs2230926: OR = 1.48, 95% CI = 1.17-1.86, p = 0.001; rs10499194: OR = 2.00, 95% CI = 1.46-2.74, p < 0.001).
|
24884566 |
2014 |
rs10499194
|
|
Rheumatoid Arthritis
|
|
0.880 |
GeneticVariation
|
BEFREE |
Childhood-onset RA was associated with TNFAIP3 rs10499194 (OR 0.60 [95% confidence interval 0.44-0.83]), PTPN22 rs2476601 (OR 1.61 [95% confidence interval 1.11-2.31]), and STAT4 rs7574865 (OR 1.41 [95% confidence interval 1.06-1.87]) variants.
|
23450725 |
2013 |
rs10499194
|
|
Rheumatoid Arthritis
|
|
0.880 |
GeneticVariation
|
BEFREE |
This meta-analysis confirms that the TNFAIP3 polymorphisms are associated with RA susceptibility in different ethnic groups, namely, in Europeans for rs6920220 and in Asians for rs10499194.
|
22402800 |
2012 |
rs10499194
|
|
Rheumatoid Arthritis
|
|
0.880 |
GeneticVariation
|
BEFREE |
The intergenic SNP rs10499194 was also associated with SLE and RA, while the risk allele for RA in Caucasians was protective against the diseases in our population.
|
20112363 |
2010 |
rs10499194
|
|
Rheumatoid Arthritis
|
|
0.880 |
GeneticVariation
|
BEFREE |
The next most strongly associated SNP was rs13207033 [P = 0.0001, OR (95% CI) 0.86 (0.8-0.93)] which was perfectly correlated with rs10499194, a SNP previously associated with RA in a US/European series.
|
19417005 |
2009 |
rs10499194
|
|
Rheumatoid Arthritis
|
|
0.880 |
GeneticVariation
|
BEFREE |
However, we were able to replicate the association signals between RA and HLA-DRB1 alleles, STAT4 (rs7574865), PTPN22 (rs2476601) and OLIG3/TNFAIP3 (rs10499194 and rs6920220).
|
19445664 |
2009 |
rs10499194
|
|
Rheumatoid Arthritis
|
|
0.880 |
GeneticVariation
|
BEFREE |
In a concurrent study, the Wellcome Trust Case Control Consortium (WTCCC) has reported strong association of rheumatoid arthritis susceptibility to a different SNP located 3.8 kb from rs10499194 (rs6920220; P = 5 x 10(-6) in WTCCC).
|
17982456 |
2007 |
rs10499194
|
|
Rheumatoid Arthritis
|
C |
0.880 |
GeneticVariation
|
GWASDB |
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.
|
17982456 |
2007 |
rs10499194
|
|
Rheumatoid Arthritis
|
C |
0.880 |
GeneticVariation
|
GWASCAT |
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.
|
17982456 |
2007 |