|
rs2228145
|
|
Rheumatoid Arthritis
|
A |
0.850 |
GeneticVariation
|
GWASCAT |
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.
|
30423114 |
2019 |
|
rs2228145
|
|
Rheumatoid Arthritis
|
|
0.850 |
GeneticVariation
|
BEFREE |
The recent meta-analysis of GWAS has expanded the total number of RA-associated loci to more than 100, out of which approximately ∼97% (98 variants) loci are located in non-coding regions, and the other ∼3% (3 variants) are in three different non-HLA genes, i.e., TYK2 (Prp1104Ala), IL6R (Asp358Ala), and PTPN22 (Trp620Arg).
|
30899276 |
2019 |
|
rs2228145
|
|
Rheumatoid Arthritis
|
A |
0.850 |
GeneticVariation
|
GWASCAT |
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.
|
24532676 |
2015 |
|
rs2228145
|
|
Rheumatoid Arthritis
|
A |
0.850 |
GeneticVariation
|
GWASCAT |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
|
rs2228145
|
|
Rheumatoid Arthritis
|
|
0.850 |
GeneticVariation
|
BEFREE |
Interleukin-6-receptor polymorphisms rs12083537, rs2228145, and rs4329505 as predictors of response to tocilizumab in rheumatoid arthritis.
|
24978393 |
2014 |
|
rs2228145
|
|
Rheumatoid Arthritis
|
A |
0.850 |
GeneticVariation
|
GWASDB |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
|
rs2228145
|
|
Rheumatoid Arthritis
|
|
0.850 |
GeneticVariation
|
BEFREE |
Although a common, non-synonymous variant in the IL-6 receptor gene (IL6R Asp358Ala; rs2228145 A>C) is associated with the risk of several common diseases, with the 358Ala allele conferring protection from coronary heart disease (CHD), rheumatoid arthritis (RA), atrial fibrillation (AF), abdominal aortic aneurysm (AAA), and increased susceptibility to asthma, the variant's effect on IL-6 signaling is not known.
|
23593036 |
2013 |
|
rs2228145
|
|
Rheumatoid Arthritis
|
|
0.850 |
GeneticVariation
|
GWASDB |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
rs2228145
|
|
Rheumatoid Arthritis
|
|
0.850 |
GeneticVariation
|
BEFREE |
In conclusion, our results do not confirm an association of IL6R rs2228145 and IL6ST/gp130 rs2228044 polymorphisms with CV disease in RA.
|
21981268 |
2011 |
|
rs2228145
|
|
Rheumatoid Arthritis
|
|
0.850 |
GeneticVariation
|
BEFREE |
An association between disease status and the sIL-6R rs8192284 (A358D) variant was tested in 965 patients with RA and 988 unrelated healthy controls.
|
19713205 |
2010 |