|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thrombophilic profile (factor V G1691A (Leiden), factor V H1299R (R2), prothrombin G20210A, MTHFR C677T, MTHFR A1298C, factor XIII V34L, β-fibrinogen-455 G-A and plasminogen activator inhibitor (PAI)-1 4G/5G) was evaluated using the cardiovascular diseases (CVD) StripAssay based on DNA isolation, PCR and reverse hybridisation.
|
31300468 |
2019 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two genes of the CVD panel demonstrated a strong relationship with RPL, including, MTHFR (C677T homozygosity, A1298C homozygosity, and compound heterozygosity for C677T and A1298C) and Factor II (heterozygosity for G20210A).
|
29974397 |
2018 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Influence of MTHFR C677T gene polymorphism in the development of cardiovascular disease in Egyptian patients with rheumatoid arthritis.
|
28215593 |
2017 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Epidemiological studies, which provide a separate line of evidence to link this gene with blood pressure, show that the 677C→T polymorphism in MTHFR increases the risk of hypertension by 24-87% and CVD by up to 40%, albeit with a large geographical variation in the extent of excess disease risk suggestive of a gene-environment interaction.
|
27720779 |
2017 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
To detect MTHFR (C677T) gene polymorphism, and to find its association with CVD risk, Hcy and folic acid levels in patients with LP.
|
28463405 |
2017 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
A total of nine gene variants/polymorphisms - F5 (Leiden - R5 06Q, rs6025), F2 (20210G > A, rs1799963), F13A1 (V34L, rs5985), MTHFR (677C > T - A222V, rs1801133), MTHFR (1298A > C - E429A, rs1801131), FGB (-455G > A -c.-463G > A; rs1800790), SERPINE1 (PAI14G/5G - rs1799889), ACE (ACE I/D, rs1799752), ITGB3 (GPIIIa L33P, rs5918) and the APOE E2/E3/E4 alleles (rs7412, rs429358) - were genotyped in 200 newly diagnosed ischemic stroke (IS) patients, 165 patients with ischemic coronary heart disease (CHD) and 159 controls with no cerebroor cardiovascular disease (non-CVD).
|
27629735 |
2016 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Does the MTHFR C677T gene polymorphism indicate cardiovascular disease risk in type 2 diabetes mellitus patients?
|
25537992 |
2015 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings indicate that the MTHFR 677C>T polymorphism may be associated with an elevated risk for CVD in ESRD patients, especially among Asians.
|
25050994 |
2014 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analyses have suggested an effect of MTHFR C677T genotype (rs1801133), a proxy for blood total homocysteine, on cardiovascular disease (CVD) in populations with low population dietary folate.
|
24458267 |
2014 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Mutation analyses were conducted using the real-time polymerase chain reaction method to screen six common mutations (Factor V G1691A, PT G20210A, Factor XIII V34L, MTHFR A1298C and C677T and PAI-1 -675 4G/5G) found in CVD panel.
|
24532105 |
2014 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significant association was found between c.677C>T</span> polymorphism and risk of CVD when all studies pooled with random-effects model for T versus C (OR 1.33; 95 % CI 1.11-1.59; p = 0.002), TT vs. CC (OR 1.87; 95 % CI 1.35-2.60; p = 3.53E-04), TT+CT vs. CC (OR 1.32; 95 % CI 1.06-1.64; p = 0.014) and TT vs. CT+CC (OR 1.75; 95 % CI 1.29-2.37; p = 6.57E-04).
|
24264431 |
2014 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common C677T polymorphism in MTHFR has been associated with an increased risk for the development of cardiovascular disease, Alzheimer's disease, and depression in adults, and of neural tube defects in the fetus.
|
23116396 |
2013 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Intervention with riboflavin was recently shown to produce genotype-specific lowering of blood pressure (BP) in patients with premature cardiovascular disease homozygous for the 677C→T polymorphism (TT genotype) in the gene encoding the enzyme methylenetetrahydrofolate reductase (MTHFR).
|
23608654 |
2013 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
We recently reported that the elevated blood pressure (BP) observed in patients with cardiovascular disease who are homozygous for the 677C→T polymorphism (TT genotype) in the gene encoding methylenetetrahydrofolate reductase (MTHFR) was responsive to supplementation with riboflavin-the cofactor for MTHFR.
|
22277556 |
2012 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genes functioning in folate-mediated 1-carbon metabolism are hypothesized to play a role in cardiovascular disease (CVD) risk beyond the current narrow focus on the MTHFR 677 C→T (rs1801133) polymorphism.
|
22649255 |
2012 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
We targeted the MTHFR C677T variant, because it is associated with risk for cardiovascular disease, and features of MetS in adults without psychiatric illness.
|
22832733 |
2012 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The methylenetetrahydrofolate reductase (MTHFR) 677 C→T polymorphism may be associated with elevated total homocysteine (tHcy) levels, an independent risk factor for cardiovascular disease.
|
22782530 |
2012 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The variant methylenetetrahydrofolate reductase (MTHFR) C677T is associated with elevated homocysteine levels, cardiovascular disease and stroke, which supports a causal relationship between hyperhomocysteinemia and vascular disease.
|
23285280 |
2012 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
After adjustment for ethnic group and other CVD risk factors, the MTHFR C677T TT genotype was associated with significantly lower CVD mortality (HR: 0.69; 95% CI: 0.50, 0.
|
22492374 |
2012 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the present work was to examine possible genetic risk factors related to the occurrence of cerebrovascular disease (CVD) in Brazilian population, the frequency of β(S)-globin gene haplotypes and co-inheritance with α-thalassemia (-α(3.7kb)) and single nucleotide polymorphism of methylenetetrahydrofolate reductase (MTHFR-C677T), Factor V Leiden (FV-G1691A) and prothrombin (PT-G20210A) genes in children from Rio de Janeiro.
|
21755116 |
2011 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR C677T and CBS 844ins68 variants tested in this study, individually or combined, are not associated with CVD in the Algerian population.
|
20939734 |
2010 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the 677C-->T polymorphism in MTHFR.
|
19952781 |
2010 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common polymorphism in the MTHFR gene (677C --> T) results in reduced enzymatic activity, and is associated with an increased risk for neural tube defects and cardiovascular disease.
|
19609317 |
2009 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Prevalence of methylenetetrahydrofolate gene (MTHFR) C677T polymorphism among chronic hemodialysis patients and its association with cardiovascular disease: a cross-sectional analysis.
|
19466593 |
2009 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism has been shown to be associated with cardiovascular disease and in patients with end-stage renal disease (ESRD).
|
17899317 |
2008 |