Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The meta-analysis results demonstrated that TCF7L2 rs4506565, rs7901695, rs11196205 and rs12255372 polymorphisms were all significantly associated with susceptibility to T2DM in general population. 31288068

2020

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Puerto Ricans with the TCF7L2-rs7903146 and rs12255372 T2D risk genotypes, although still high, had better anthropometric profiles when adhering to a MedDiet, suggesting that this diet may offset unfavorable genetic predisposition. 31504696

2020

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE BMI and rs12255372 are associated with the risk of conversion to IGT and T2DM [OR = 1.07 (95% IC 1.0-1.14, p = .041; OR =2.14, 95% IC 1.01-4.55, p = .04 respectively), while the lactation shows a strong protective effects OR = 0.15 (95% IC 0.062-0.39, p = .00007), and an apparent interaction with rs12255372T decreasing the risk in carriers (OR =2.15; 95% IC 0.97-4.7, p = .05). 30614312

2019

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE In conclusion, rs7903146 and rs12255372 were significantly associated with T2DM in the specified Northern Iranian population. 30776466

2019

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Adjusting also for T2D-related covariates, body mass index (BMI), and ancestry did not change the results substantively (rs7901695, p = 0.003; rs7903146, p = 0.005; rs11196205, p = 0.001; and rs12255372, p = 0.005). 31676834

2019

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The presence of the rs12255372 and rs7903146 TCF7L2 gene variants plays an important role in the development of T2DM among individuals with MS. 29971604

2018

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The associations between SNPs of TCF7L2 (rs7903146 and rs12255372), SLC16A11 (rs13342232), and ABCA1 (rs9282541) with T2D were analyzed. 28101933

2017

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The <i>KCNJ11</i> SNP rs5210 was associated with T2DM, the <i>TCF7L2</i> SNP rs11196175 was associated with BMI and cholesterol and LDL levels, the <i>TCF7L2</i> SNP rs12255372 was associated with BMI and HDL, VLDL and triglyceride levels, and the <i>HNF4A</i> SNP rs1885088 was associated with LDL levels (P<0.05). 28352326

2017

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE An interaction (p = 0.048) between TCF7L2 variants and coffee intake was apparent, with an inverse association between coffee and type 2 diabetes present among carriers of the diabetes risk allele (T) in rs12255372 (GG: HR 0.99 [95% CI 0.97, 1.02] per cup of coffee; GT: HR 0.96 [95% CI 0.93, 0.98]); and TT: HR 0.93 [95% CI 0.88, 0.98]). 27623947

2016

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The GG genotype at rs12255372 favourably influences treatment success with sulfonylurea therapy in patients with type 2 diabetes (p⩽0.05). 27639123

2016

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The T-allele of the SNP rs12255372 of TCF7L2 (OR = 2.70, 95% CI = 1.12-6.49, P = 0.027) and the A-allele of PDX-1 D76N (OR = 3.93, 95% CI = 1.60-7.68, P = 0.002) were significantly associated with an increased risk of T2DM. 26058934

2015

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE These findings suggest that the TCF7L2 rs12255372 (G>T) polymorphism might be one of the most important genetic factors associated with T2DM susceptibility, and that individuals in the Chinese Hui population who carry a G allele at this locus might be at risk to develop T2DM. 26345943

2015

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Our results revealed a strong association between risk T alleles in variants rs12255372 (OR: G/T=1.4233; T/T=2.0395) and rs4506565 (OR: A/T=1.6066; T/T=3.1301) and T2DM among the Saudi population of the Eastern Province of Saudi Arabia. 26367734

2015

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE For total participants and male, the distribution of rs12255372 alleles and the dominant model (Guanine Guanine (GG) genotype vs. Guanine Thymine (GT) genotype + Thymine Thymine (TT) genotype) showed significant difference between T2DM and control subjects (for allele: p = 0.013 and p = 0.002, respectively; for dominant model: p = 0.028 and p = 0.008, respectively). 26393635

2015

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Given the overlap between PCOS and T2DM, we investigated the association of transcription factor-7-like 2 (TCF7L2) variants rs4506565, rs7903146, rs12243326, and rs12255372 with the susceptibility to PCOS. 24157263

2014

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE These data suggest that the TCF7L2 SNPs rs7903146 and rs12255372 may not significantly contribute to T2D susceptibility in this population. 25299103

2014

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Individuals homozygous for rs7903146 and rs12255372 T2D risk alleles (TT/TT) expressed 2.6-fold greater levels of TCF7L2 mRNA compared to individuals homozygous for the non-risk alleles (CC/GG, p = 0.006), although differentially spliced TCF7L2 transcripts did not differ by T2D risk-associated genotype. 22402060

2013

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Three TCF7L2 polymorphisms (rs7903146, rs7901695 and rs12255372) have been analyzed by allelic discrimination assays in a cohort of 154 Italian patients with T2DM and 171 healthy controls. 22843023

2013

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Four single nucleotide polymorphisms (rs290487, rs7903146, rs11196205, and rs12255372), closely associated with type 2 diabetes in the Eastern Asia population, were genotyped and analyzed. 23041303

2013

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The four tested TCF7L2 variants were in linkage disequilibrium, and 4-locus (rs4506565, rs7903146, rs12243326, rs12255372) haplotype analysis demonstrated that haplotype 1111 was negatively associated (Pc<0.001), while haplotypes 2222 (Pc=0.008) and 2211 (Pc=0.020) were positively associated with T2DM risk, after controlling for a number of covariates. 23142382

2013

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE There was no evidence that rs12255372G/T and rs290487T/C polymorphisms increased T2DM risk (T vs. G, OR = 1.77, 95% CI = 0.88-3.56; C vs. T, OR = 1.08, 95% CI = 0.93-1.25). 23527206

2013

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE In summary, by pooling all available qualified data from genetic studies on rs12255372 and T2DM, we have confirmed that rs12255372 is significantly associated with susceptibility to T2DM in the global population. 23579632

2013

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE PCOS carriers of the rs12255372 T (TCF7L2 Caucasian type 2 diabetes mellitus (T2D) locus) had no significant associated metabolic phenotypes. 22301903

2012

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE TCF7L2 variants rs12255372 and rs7903146 have been associated with risk of Type 2 diabetes. 23085767

2012

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Haplotype analysis (rs7901695-rs4506565-rs7903146-rs12243326-rs7895340-rs11196205-rs12255372) identified positively- (2122112, 2222222) and negatively- (1111111) T2DM-associated haplotypes. 23107111

2012