Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Lys23Lys/CC combination was associated with a 2.65-fold increased likelihood of T2D (OR = 2.65, 95% CI 1.12-6.28), whereas the Glu23Lys/CT combination also increased such likelihood (OR = 3.88, 95% CI 1.27-11.91). 30467975

2019

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE This study showed that rs5219 polymorphism of the KCNJ11 gene is an important risk factor for type 2 diabetes mellitus in a sample of the Syrian population. 31195986

2019

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
T 0.900 GeneticVariation GWASCAT Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. 29632382

2018

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The results suggest that E23K may have a greater effect on the development of T2D in female Chinese youth. 28449408

2018

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE There was a believable evidence to verify that rs5219 variation was associated with T2DM. 29685723

2018

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Conclusion Both dominant and additive models in both KCNJ11 (E23K, rs5219) and SDF-1β (G801A, rs1801157) genetic polymorphisms are significantly associated with type 2 diabetes. 29893194

2018

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Rs5219 at KCNJ11 (E23K) was associated with peripheral nerve function in a Chinese population with type 2 diabetes mellitus, suggesting shared genetic factors for type 2 diabetes mellitus and diabetic polyneuropathy in this population. 27253191

2017

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE They also aid our understanding of how the Kir6.2-E23K variant predisposes to type 2 diabetes. 27118464

2016

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Genome-wide association studies (GWAS) have reported that the polymorphism rs5219 of the potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11) is associated with type 2 diabetes mellitus (T2DM). 25573672

2015

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE A190A-TT or E23K-GG carriers had higher systolic blood pressure (SBP) than CC or AA carriers in the non-diabetic control and T2DM groups (both p < 0.05). 25725792

2015

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ11), rs1801282 (PPARγ), rs10811661 (CDKN2A/2B), rs13266634 (SLC30A8), rs12779790 (CDC123/CAMK1D), rs7903146 (TCF7L2), rs9282541 (ABCA1) and rs13342692 (SLC16A11) polymorphisms in the genetic background of Maya population to associate their susceptibility to develop T2D. 25839936

2015

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE We included 44 original studies published by June 2014 in a meta-analysis of the p.E23K association with T2DM. 25955821

2015

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Genetic analysis revealed a novel variant (p.Pro190Leu) in HNF4A, which is located in the ligand binding domain of the transcription factor, and the p.Glu23Lys variant in KCNJ11, which is associated with type 2 diabetes. 26315042

2015

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Our results revealed the risk of type 2 diabetes conferred by KCNJ11 E23K gene variant in the Mauritanian population. 24332549

2014

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The KCNJ11 E23K polymorphism is not associated with genetic susceptibility to type 2 diabetes in the Iranian population; however, it may play a role in disease progression in the presence of obesity. 24460047

2014

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The current meta-analysis demonstrated that a modest but statistically significant effect of the 23K allele of rs5219 polymorphism in susceptibility to T2D. 24710510

2014

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Using MGA, some common gene variants were found to have little (<5%) but significant impact on the heritability of T2D related QTs [KCNJ11 (rs5219), p=0.004]; [IGF2BP2 (rs4402960), p=0.02]; [SLC30A8 (rs13266634), p=0.05]; [CAPN10 (rs2975760), p=0.031]; [FTO (rs8050136), p=0.023]; [FTO (rs9939609), p=0.018] and [SLC30A8 (rs13266634), p=0.05]. 24993573

2014

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The findings of the present study suggest that the KCNJ11 E23K variant is associated with a greater effect of sulphonylurea treatment in newly diagnosed Chinese patients with T2DM. 25115353

2014

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Both case-control and meta-analyses results revealed the significant association between the E23K variant of KCNJ11 and Type 2 diabetes among Tunisians and Arabs. 25165692

2014

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE KCNJ11 rs5219 is not independently associated with T2D in South-Indian population and our meta-analysis suggests that KCNJ11 polymorphism (rs5219) is associated with risk of T2D in East Asian population and global population but this outcome could not be replicated in South Asian sub groups. 25247988

2014

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE In contrast, no significant association was observed between the KCNJ11 E23K gene polymorphism and T2D in the dominant genetic model (OR: 0.66, 95 % CI: 0.41-1.07, P = 0.09).The KCNJ11 E23K gene polymorphism is associated with T2D risk in the Chinese Han population. 23054005

2013

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Nine variants in FTO rs8050136, WFS1 rs10010131, CDKN2A/B rs10811661, KCNJ11 rs5219, CDC123/CAMK1D rs12779790, JAZF1 rs864745, SLC30A8 rs13266634, CDKAL1 rs10946398, and HHEX/IDE rs5015480 were significantly associated with T2DM (P < 0.05). 23298195

2013

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE However, rs5219 was not associated with type 2 diabetes in the Chinese Han population. 24065655

2013

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Using the random-effects model, we found a significant association between E23K (rs5219) polymorphism and T2D risk with per-allele odds ratio of 1.13 (95% confidence interval: 1.10-1.15; p<10(-5)). 22082043

2012

dbSNP: rs5219
rs5219
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Although rare monogenic activating mutations in these genes cause overt neonatal diabetes, the common variants E23K (KCNJ11) and S1369A (ABCC8) form a tightly heritable haplotype that is associated with an increased susceptibility to type 2 diabetes (T2D) risk. 22187380

2012