|
rs7923837
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
The finding revealed the all measured inheritance models of rs1111875G/A and of rs5015480C/T variants dramatically increase the risk of T2D while another polymorphism (rs7923837A/G) was not associated with risk/protective role in T2D.
|
31237015 |
2019 |
|
rs7923837
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
Association to type 2 diabetes was found for rs13266634 (SLC30A8), rs7923837 (HHEX), rs10811661 (CDKN2A/2B), rs4402960 (IGF2BP2), rs12779790 (CDC123/CAMK1D), and rs2237892 (KCNQ1).
|
22923468 |
2012 |
|
rs7923837
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
GWASDB |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
rs7923837
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our results confirm that genetic variants of the IDE-KIF11-HHEX region at 10q23.33 contribute to type 2 diabetes susceptibility and suggest that rs7923837 may represent the strongest signal related to type 2 diabetes risk in the Chinese Han population.
|
22506066 |
2012 |
|
rs7923837
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our results provide clarification to the significant association of rs1111875, rs5015480 and rs7923837 in HHEX gene with type 2 diabetes.
|
23166797 |
2012 |
|
rs7923837
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
|
22158537 |
2011 |
|
rs7923837
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrated that the risk allele of HHEX polymorphisms (rs1111875 and rs7923837) is a risk factor for developing T2D.
|
21059810 |
2011 |
|
rs7923837
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
Three SNPs-rs7756992 (P = .007), rs7754840 (P = .015), and rs6931514 (P = .029)-of the CDKAL1, rs7020996 (P = .003) of the CDKN2A/B gene, rs7923837 (P = .038) of the HHEX gene, and rs12056034 (P = .033) of the BAZ1B gene were associated with T2D in our population.
|
20580033 |
2010 |
|
rs7923837
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
In addition, we also confirmed that three SNPs (rs1111875, rs7923837 and rs5015480) in HHEX , one SNP (rs10946398) in CDKAL1, and three SNPs (rs13266634, rs3802177 and rs11558471) in SLC30A8 were significantly associated with T2D in the population being studied.
|
20550665 |
2010 |
|
rs7923837
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our data show that the major type 2 diabetes risk-conferring G allele of rs7923837 at the HHEX-IDE locus was associated with higher pediatric BMI in both the discovery (P = 0.0013 and survived correction for 20 tests) and replication (P = 0.023) sets (combined P = 1.01 x 10(-4)).
|
19933996 |
2010 |
|
rs7923837
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
In our case-control subjects, susceptibility to type 2 diabetes was replicated in TCF7L2 (rs12255372), CDKAL1 (rs7756992, rs7754840), HHEX (rs7923837), IGF2BP2 (rs4402960 and rs1470579), CDKN2A/B (rs10811661), and SLC30A8 (rs13266634).
|
19033397 |
2009 |
|
rs7923837
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
In the present study, we aimed to validate the type 2 diabetes (T2DM) susceptibility alleles identified in the first genome-wide association study in the hematopoietically expressed homeobox protein (HHEX) gene region (rs1111875 and rs7923837).
|
19117022 |
2009 |
|
rs7923837
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
A case-control design comprising 884 type 2 diabetic patients and 513 control subjects living in the East-Center of Tunisia was used to analyze the contribution to T2D of the following SNPs: E23K in KCNJ11/Kir6.2, K121Q in ENPP1, the -30G/A variant in the pancreatic beta-cell specific promoter of Glucokinase, rs7903146 in TCF7L2 encoding transcription factor 7-like2, and rs7923837 in HHEX encoding the homeobox, hematopoietically expressed transcription factor.
|
19368707 |
2009 |
|
rs7923837
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
A total of 15 SNPs were genotyped.Eight SNPs in five loci were found to be associated with type 2 diabetes: rs3802177 [odds ratio (OR) = 1.16 (95% confidence interval (CI) 1.05-1.27); P = 4.5 x 10(-3)] in SLC30A8; rs1111875 [OR = 1.27 (95% CI 1.14-1.40); P = 1.4 x 10(-5)] and rs7923837 [OR = 1.27 (95% CI 1.13-1.43); P = 1.0 x 10(-4)] in HHEX; rs10811661 [OR = 1.27 (95% CI 1.15-1.40); P = 1.9 x 10(-6)] in CDKN2B; rs4402960 [OR = 1.23 (95% CI 1.11-1.36); P = 8.1 x 10(-5)] and rs1470579 [OR = 1.18 (95% CI 1.07-1.31); P = 8.3 x 10(-4)] in IGF2BP2; and rs7754840 [OR = 1.28 (95% CI 1.17-1.41); P = 4.5 x 10(-7)] and rs7756992 [OR = 1.27 (95% CI 1.15-1.40); P = 9.8 x 10(-7)] in CDKAL1.
|
18477659 |
2008 |
|
rs7923837
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
For both polymorphisms, the risk for T2D was significantly increased in carriers of the major alleles (rs7923837: odds ratio (OR): 1.57, 95% confidence interval (CI): 1.08-2.27, P=0.017 and rs1111875: OR: 1.68, 95% CI: 1.19-2.35, P=0.003).
|
18231124 |
2008 |
|
rs7923837
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
The G allele of rs7923837 was associated with type 2 diabetes [odds ratio 1.66, 95% confidence interval (CI) 1.28-2.15; P = 0.00014], following the same tendency as in the French population of the previous report.
|
17971426 |
2008 |
|
rs7923837
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
The SNPs rs5015480 [odds ratio (OR) = 1.46 (95% CI 1.20-1.77), p = 2.0 x 10(-4)], rs7923837 [OR = 1.40 (95% CI 1.17-1.68), p = 2.0 x 10(-4)] and rs1111875 [OR = 1.30 (95% CI 1.11-1.52), p = 0.0013] in HHEX were significantly associated with type 2 diabetes with the same direction as previously reported.
|
17928989 |
2007 |