|
rs498872
|
|
Glioma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In addition, the genotype AA of the rs498872 (PHLDB1)</span> was associated with poor overall survival of gliomas</span> patients (AA vs. GA, p = 0.037).
|
31721021 |
2020 |
|
rs498872
|
|
Glioma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our findings suggested that the rs498</span>872 polymorphism may serve as a potential genetic biomarker of glioma in both Asians and Caucasians.
|
30684220 |
2019 |
|
rs498872
|
|
Glioma
|
A |
0.900 |
GeneticVariation
|
GWASCAT |
Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility.
|
30714141 |
2019 |
|
rs498872
|
|
Glioma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, this study found that PHLDB1 rs498872 polymorphism was significantly associated with glioma</span> risk in Chinese Han population.
|
28886307 |
2017 |
|
rs498872
|
|
Glioma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Results showed that seven hot loci were all associated with increased risk of glioma (rs2736100, OR = 1.28, 95 %CI = 1.23-1.32; rs4295627, OR = 1.34, 95 %CI = 1.21-1.47; rs4977756, OR = 1.24, 95 %CI = 1.20-1.28; rs498872, OR = 1.24, 95 %CI = 1.15-1.33; rs6010620, OR = 1.29, 95 %CI = 1.24-1.35; rs11979158: OR = 1.18, 95 %CI = 1.10-1.25; rs2252586: OR = 1.18, 95 %CI = 1.10-1.25).
|
26243184 |
2016 |
|
rs498872
|
|
Glioma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that rs498872 polymorphism was associated with increased risk of glioma.
|
24935770 |
2015 |
|
rs498872
|
|
Glioma
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found 1.17-1.34-fold increased risk of glioma associated with rs498872 genotypes (OR 1.34, 95% CI 1.22-1.46; OR 1.24, 95% CI 1.14-1.35; OR 1.20, 95% CI 1.10-1.31; OR 1.17, 95% CI 1.08-1.27).
|
25182002 |
2015 |
|
rs498872
|
|
Glioma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Case-control analyses stratified into 4 molecular classes (defined by 1p-19q status, IDH mutation, and EGFR amplification) showed an association of rs4295627 and rs498872 with IDH-mutated gliomas (P < 10(-3)) and rs2736100 and rs6010620 with IDH wild-type gliomas (P < 10(-3) and P = .03).
|
23161787 |
2013 |
|
rs498872
|
|
Glioma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Four of the five SNPs previously reported by others were statistically significantly associated with increased risk of glioma in our study (rs2736100, rs4295627, rs4977756, and rs6010620); rs498872 was not associated with glioma in our study.
|
23903690 |
2013 |
|
rs498872
|
|
Glioma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism (SNP) at locus 11q23.3 (rs498872) in the near 5'-UTR of the PHLDB1 gene was recently implicated as a risk factor for gliomas in a genome-wide association study, and this involvement was confirmed in three additional studies.
|
23300798 |
2012 |
|
rs498872
|
|
Glioma
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
|
rs498872
|
|
Glioma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
|
rs498872
|
|
Glioma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Overall, the authors identified 3 susceptibility loci for glioma risk at 20q13.33 (RTEL1 rs6010620 (P = 2.79 × 10(-6))), 11q23.3 (PHLDB1 rs498872 (P = 3.8 × 10(-6))), and 5p15.33 (TERT rs2736100 (P = 3.69 × 10(-4))) in this study population; these loci were also associated with glioblastoma risk (20q13.33: RTEL1 rs6010620 (P = 3.57 × 10(-7)); 11q23.3: PHLDB1 rs498872 (P = 7.24 × 10(-3)); 5p15.33: TERT rs2736100 and TERT rs2736098 (P = 1.21 × 10(-4) and P = 2.84 × 10(-4), respectively)).
|
21350045 |
2011 |
|
rs498872
|
|
Glioma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Seven independent chromosomal loci have robustly been associated with glioma risk: 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1), and two loci at 7p11.2 (rs11979158 and rs2252586, EGFR).
|
21825990 |
2011 |
|
rs498872
|
|
Glioma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genome-wide association data have identified common genetic variants at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 11q23.3 (rs498872, PHLDB1), and 20q13.33 (rs6010620, RTEL1) as determinants of glioma risk.
|
20462933 |
2010 |
|
rs498872
|
|
Glioma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our group identified 5 risk loci for glioma susceptibility (TERT rs2736100, CCDC26 rs4295627, CDKN2A/CDKN2B rs4977756, RTEL1 rs6010620, and PHLDB1 rs498872).
|
20212223 |
2010 |
|
rs498872
|
|
Glioma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genome-wide association studies have recently identified single-nucleotide polymorphisms (SNP) in five loci at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A/CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1) to be associated with glioma risk.
|
20847058 |
2010 |
|
rs498872
|
|
Glioma
|
T |
0.900 |
GeneticVariation
|
GWASCAT |
We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)).
|
19578367 |
2009 |
|
rs498872
|
|
Glioma
|
|
0.900 |
GeneticVariation
|
BEFREE |
We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)).
|
19578367 |
2009 |
|
rs498872
|
|
Glioma
|
T |
0.900 |
GeneticVariation
|
GWASDB |
We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)).
|
19578367 |
2009 |