Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs854560
rs854560
PON1
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.060 GeneticVariation BEFREE To investigate whether ambient agricultural OP exposure and PON1 L55M influence the rate of motor, cognitive, and mood-related symptom progression in PD. 28689109

2017
dbSNP: rs854560
rs854560
PON1
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.060 GeneticVariation BEFREE In Parkinson's disease most of the studies suggest no participation of either L55M or the Q192R polymorphisms in its pathogenesis. 24225313

2014
dbSNP: rs854560
rs854560
PON1
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.060 GeneticVariation BEFREE The polymorphism Leu54Met (rs854560) in PON1, impairing enzyme activity and leading to decreased PON1 expression levels, has been reported to be associated with Parkinson's disease (PD). 22704918

2012
dbSNP: rs854560
rs854560
PON1
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.060 GeneticVariation BEFREE Case-control studies of PON1 genetic variants in Alzheimer's disease (AD) and Parkinson's disease (PD) have revealed some positive albeit inconsistent associations with 2 PON1 coding polymorphisms: Q192R (rs662) and L55M (rs854560). 20947215

2012
dbSNP: rs854560
rs854560
PON1
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.060 GeneticVariation BEFREE Paraoxonase 1 polymorphisms L55M and Q192R were not risk factors for Parkinson's disease: a HuGE review and meta-analysis. 22521594

2012
dbSNP: rs854560
rs854560
PON1
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.060 GeneticVariation BEFREE Our results suggest that the M54L and Q192R polymorphisms are not major risk factors for PD in the Finnish population. 15331145

2004