|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
While C677T is known to play major roles in the risk of adult schizophrenia, our finding for the first time suggests an age-specific association between MTHFR polymorphisms and schizophrenia.
|
31302825 |
2019 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association study of methylenetetrahydrofolate reductase genetic polymorphism 677C>T with schizophrenia in hospitalized patients in population of European Russia.
|
29202425 |
2018 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T and COMT Val158Met interact with CA to increase risk of schizophrenia.
|
28556887 |
2017 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion the results of the present meta-analysis suggested that the MTHFR C677T polymorphism is a ris</span>k factor for schizophrenia</span>.
|
27025471 |
2016 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Previous studies suggest that elevated total homocysteine levels and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, which correlates with plasma total homocysteine levels, are risk factors for schizophrenia (SCZ).
|
27810229 |
2016 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis showed that MTHFR C677T was significantly associated with SZ, the highest OR was found for the recessive model (for TT vs. CT + CC: OR = 1.34, 95% CI: 1.18-1.53); a marginal association of MTHFR C677T with increased risk of BPD has also been found for the recessive model (OR = 1.26, 95% CI: 1.00-1.59).
|
24938371 |
2015 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present findings suggest that the MTHFR C677T polymorphisms are likely to be associated with the risk of developing BD and schizophrenia and influence the age at onset of BD but not the age at onset of schizophrenia.
|
25101272 |
2014 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim was to detect a serum level of Hcy, examine the associations between the level of Hcy, methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and clinical properties for patients with schizophrenia, mood disorders and in a control group.
|
23586533 |
2014 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The meta-analysis of the Japanese genetic association studies demonstrated a significant association between the MTHFR C677T polymorphism and schizophrenia.
|
24535549 |
2014 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphism is associated with antipsychotic-induced weight gain in first-episode schizophrenia.
|
24229535 |
2014 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The case-control association study results showed that the MTHFR C677T was associated with schizophrenia (χ(2)=14.11, P=1.74 × 10(-4), OR=0.79; 95% CI=0.70-0.89).
|
23318463 |
2013 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
While MTHFR C677T and A1298C polymorphisms were not previously studied in an Arab population with respect to the susceptibility for developing schizophrenia, the MTRR A66G was not previously investigated in any population around the world.
|
22813657 |
2012 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
DNA methylation in schizophrenia subjects: gender and MTHFR 677C/T genotype differences.
|
22690662 |
2012 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met and methylenetetrahydrofolate reductase (MTHFR) C677T has been shown to differentially affect cognition in patients with schizophrenia and healthy controls; the effect of COMT Val158Met × MTHFR interaction on resilience to stress in patients and controls remains to be examined.
|
22128864 |
2012 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Extending the study to five Nordic samples consisting of 2,198 patients with schizophrenia, including the original Scandinavian samples, there was no significant association between MTHFR C677T polymorphism and age at onset in schizophrenia.
|
23076983 |
2012 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A hypomethylating variant of MTHFR, 677C>T, blunts the neural response to errors in patients with schizophrenia and healthy individuals.
|
21980405 |
2011 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated a possible interaction between MTHFR 677C>T polymorphism and winter birth in the development of schizophrenia in a group of 742 schizophrenia patients and 884 control subjects.All subjects were of Dutch ancestry.
|
21093223 |
2011 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The T-allele of the C677T polymorphism has recently been associated with earlier age at onset of schizophrenia.
|
21302350 |
2011 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined whether the hypofunctional 677C>T variant in MTHFR, a candidate schizophrenia risk gene, contributed to our previous findings of blunted error-related dACC activation and reduced microstructural integrity of dACC white matter.
|
21190096 |
2011 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Folate deficiency and the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism have been linked to negative symptoms in schizophrenia both independently and synergistically.
|
21334854 |
2011 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T was significantly associated with all of the combined psychiatric disorders (SZ, BPD and UDD); random effects odds ratio (OR)=1.26 for TT versus CC genotype carriers; confidence interval (CI) 1.09-1.46); meta-regression did not suggest moderating effects of psychiatric diagnosis, sex, ethnic group or year of publication.
|
21185933 |
2011 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no significant association between either of the two polymorphisms and the risk of schizophrenia (chi-square = 0.001, df = 1, P = 0.971 for C677T; chi-square = 1.319, df = 1, P = 0.251 for A1298C).
|
22022190 |
2011 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, this study found no support that maternal/child MTHFR C677T genotype and maternal folate intake during pregnancy contribute to common aetiological pathways that are shared between schizophrenia and non-clinical psychotic symptoms in adolescents, assuming that decreased folate-status increases schizophrenia risk.
|
20418067 |
2010 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR C677T polymorphism may play a role as a modifying factor for age of onset in schizophrenia.
|
19746410 |
2010 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase C677T polymorphism, are risk factors for schizophrenia.
|
19939410 |
2010 |