Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE CACNA1C-rs1006737 and ZNF804A-rs1344706 polymorphisms are among the most robustly associated with schizophrenia (SCZ) and bipolar disorder (BD), and recently with brain phenotypes. 30079586

2019

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE ZNF804A rs1344706 has been identified as one of the risk genes for schizophrenia. 30852803

2019

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE rs1344706 risk allele carriers of schizophrenia had increased gray matter in the brain regions including frontal lobe, temporal lobe, and other brain regions, but the carriers of healthy individuals had decreased gray matter and white matter integrity in the frontal lobe, central network, and other brain regions. 30962687

2019

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE Previous studies indicated that single-nucleotide polymorphism (SNP) rs1344706 in ZNF804A was strongly associated with schizophrenia and might influence social interaction. 31122238

2019

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE The biological function of ZNF804A rs1344706, the first genome-wide supported risk variant of schizophrenia, remains largely unknown. 28078547

2018

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE Nevertheless, we could not replicate the association of rs1344706 with schizophrenia. 29112096

2018

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE Neither univariate nor multivariate analyses showed any associations between indices of grey matter and rs1344706 variation in schizophrenia or healthy participants. 29247760

2018

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE Our results elucidated the contribution of rs1344706 to functional connectivity within the brain network, and may have important implications for our understanding of this risk gene's role in functional dysconnectivity in schizophrenia. 29527501

2018

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE Three SNPs (rs1625579, rs1344706 and rs4765905) showed a consistent direction of effect with previous studies and the polygenic risk score constructed using the weighted sum of these three SNPs showed a significant association with Schizophrenia in this population (OR=3.78, p=0.005). 29599094

2018

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE The homozygous ZNF804A rs1344706 genotype (AA) conferred a high risk of schizophrenia, and also exhibited significantly decreased resting functional coupling between the left hippocampus and right DLPFC (F(2,165) = 13.43, P < 0.001). 29611035

2018

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE Put in perspective, ZNF804A rs1344706, not only had a significant main effect, but its SZ-specific effects were two orders of magnitude more widespread than that of CACNA1C rs1006737. 27790829

2017

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE Besides, positive association of rs1344706 with schizophrenia was observed in Northern Chinese (P = 0.005). 28120939

2017

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE Its intronic single-nucleotide polymorphism (SNP) rs1344706 is among one of the strongest susceptibility variants that have achieved genome-wide significance in genome-wide association studies (GWAS) for schizophrenia and has been widely and intensively studied. 28289284

2017

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE Our result suggests that genetic variant rs1344706 might be associated with the development of schizophrenia in Asians. 28883732

2017

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE Taken together, the disconnectivity of the lHF-PCC tract seems to be a plausible intermediate phenotype that links rs1344706 and schizophrenia. 26654932

2016

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE Though the two SNPs did not remain significant if we applied multiple corrections, our analysis should be interpreted as a primary replication study with in prior hypothesis, and rs1344706 and rs1366842 might confer a small but detectable risk of schizophrenia (and bipolar disorder) in Asians. 26866941

2016

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE Our results did not support the association of rs1344706 with schizophrenia in Han Chinese, and further association studies with large samples from other ethnic backgrounds and focus on more SNPs of ZNF804A are warranted. 26934312

2016

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE Analysing the groups separately (at p < 0.001, uncorrected), variation in rs1344706 showed effects on brain structure within the schizophrenia patients in several areas including the left and right inferior temporal, right supramarginal/superior temporal, right and left inferior frontal, left frontopolar, right and left dorsolateral/ventrolateral prefrontal cortices, and the right thalamus, as well as effects within the healthy controls in left lateral temporal, right anterior insula and left orbitofrontal cortical areas. 25065377

2015

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE Here, we review literature recently published on ZNF804A, and analyze critical concepts related to the biology of ZNF804A and the role of rs1344706 in schizophrenia and bipolar disorder. 25522715

2015

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE We verified that ZNF804A was significantly related to psychiatric diseases, and the association between ZNF804A rs1344706 and psychosis (schizophrenia and bipolar disorder) did not vary with disease or ethnicity. 25667193

2015

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE Our findings suggest that ZNF804A rs1344706 may aggravate the risk for schizophrenia by exerting its effects on cortical thickness, surface area, and cortical volume in these brain regions. 25921517

2015

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE The rs1344706 single nucleotide polymorphism within ZNF804A was among the first genetic variants found to be associated with schizophrenia. 26498712

2015

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE Recent evidence indicated that the ZNF804A (rs1344706) risk allele A is associated with better cognitive performance in patients with schizophrenia. 24078172

2014

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE Although this data does not preclude the possibility of other functional variants in ZNF804A, it provides evidence that the rs1344706 SZ risk allele is the cis-regulatory variant directly responsible for this allelic expression imbalance in adult cortex. 24315717

2014

dbSNP: rs1344706
rs1344706
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation BEFREE The common variant rs1344706 within the zinc-finger protein gene ZNF804A has been strongly implicated in schizophrenia (SZ) susceptibility by a series of recent genetic association studies. 24424391

2014