rs4986790
|
|
Tuberculosis, Pulmonary
|
|
0.060 |
GeneticVariation
|
BEFREE |
Furthermore, SNPs TLR9 rs352139 and TLR8 rs3764880 were associated with PTB in the late-onset (≥39-year-old) patient group (OR = 0.60, p = 0.0029 and OR = 0.70, p = 0.021, respectively) and SNPs TLR2 rs3804099, TLR4 rs4986790 and TLR4 rs1927906 in the early-onset (≤ 38-year-old) group (OR = 0.53, p = 0.0012; OR = 3.45, p = 0.013; OR = 2.31, p = 0.044, respectively).
|
30529560 |
2019 |
rs4986790
|
|
Tuberculosis, Pulmonary
|
|
0.060 |
GeneticVariation
|
BEFREE |
BACKGROUND Findings regarding the association of the single-nucleotide polymorphisms (SNPs) rs4986790 and rs4986791 in Toll-like receptor 4 and rs187084, rs574386, and rs352139 in Toll-like receptor 9 (TLR9) with pulmonary tuberculosis (PTB) susceptibility are inconsistent.
|
25889916 |
2015 |
rs4986790
|
|
Tuberculosis, Pulmonary
|
|
0.060 |
GeneticVariation
|
BEFREE |
Human Toll-like receptor 4 polymorphisms TLR4 Asp299Gly and Thr399Ile influence susceptibility and severity of pulmonary tuberculosis in the Asian Indian population.
|
20403143 |
2010 |
rs4986790
|
|
Tuberculosis, Pulmonary
|
|
0.060 |
GeneticVariation
|
BEFREE |
In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G/A (Arg753Gln), TLR-4 896A/G (Asp299Gly), TLR-4 1196C/T (Thr399Ile), TLR-6 745C/T (Ser249Pro), TIRAP 975C/T (Ser180Leu) genes and TLR-9 promoter region polymorphisms at positions -1237C/T and -1486C/T are associated with susceptibility or resistance to pulmonary tuberculosis (PTB).
|
20797905 |
2010 |
rs4986790
|
|
Tuberculosis, Pulmonary
|
|
0.060 |
GeneticVariation
|
BEFREE |
No association between TLR4 Asp299Gly and pulmonary TB was found.
|
18008256 |
2007 |
rs4986790
|
|
Tuberculosis, Pulmonary
|
|
0.060 |
GeneticVariation
|
BEFREE |
To determine whether TLR4 Asp299Gly influences LPS responses or susceptibility to pulmonary TB in humans in a Gambian population sample.
|
15525557 |
2004 |
rs4986791
|
|
Tuberculosis, Pulmonary
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, for TLR4 rs4986791, a significant increased PTB risk was found in Africans, and for TLR9 rs352139 a significant increased PTB risk was found in Asians after subgroup analysis by ethnicity, although the enrolled studies were limited.
|
25889916 |
2015 |
rs4986791
|
|
Tuberculosis, Pulmonary
|
|
0.030 |
GeneticVariation
|
BEFREE |
Human Toll-like receptor 4 polymorphisms TLR4 Asp299Gly and Thr399Ile influence susceptibility and severity of pulmonary tuberculosis in the Asian Indian population.
|
20403143 |
2010 |
rs4986791
|
|
Tuberculosis, Pulmonary
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G/A (Arg753Gln), TLR-4 896A/G (Asp299Gly), TLR-4 1196C/T (Thr399Ile), TLR-6 745C/T (Ser249Pro), TIRAP 975C/T (Ser180Leu) genes and TLR-9 promoter region polymorphisms at positions -1237C/T and -1486C/T are associated with susceptibility or resistance to pulmonary tuberculosis (PTB).
|
20797905 |
2010 |
rs4986791
|
|
Tuberculosis, Pulmonary
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G/A (Arg753Gln), TLR-4 896A/G (Asp299Gly), TLR-4 1196C/T (Thr399Ile), TLR-6 745C/T (Ser249Pro), TIRAP 975C/T (Ser180Leu) genes and TLR-9 promoter region polymorphisms at positions -1237C/T and -1486C/T are associated with susceptibility or resistance to pulmonary tuberculosis (PTB).
|
20797905 |
2010 |
rs10759932
|
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of rs10759932 and rs2737190 in TLR4 are significantly related to both COPD and PTB but with inverse effects.
|
31640653 |
2019 |
rs1371329921
|
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G/A (Arg753Gln), TLR-4 896A/G (Asp299Gly), TLR-4 1196C/T (Thr399Ile), TLR-6 745C/T (Ser249Pro), TIRAP 975C/T (Ser180Leu) genes and TLR-9 promoter region polymorphisms at positions -1237C/T and -1486C/T are associated with susceptibility or resistance to pulmonary tuberculosis (PTB).
|
20797905 |
2010 |
rs1927906
|
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, SNPs TLR9 rs352139 and TLR8 rs3764880 were associated with PTB in the late-onset (≥39-year-old) patient group (OR = 0.60, p = 0.0029 and OR = 0.70, p = 0.021, respectively) and SNPs TLR2 rs3804099, TLR4 rs4986790 and TLR4 rs1927906 in the early-onset (≤ 38-year-old) group (OR = 0.53, p = 0.0012; OR = 3.45, p = 0.013; OR = 2.31, p = 0.044, respectively).
|
30529560 |
2019 |
rs7873784
|
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
The frequencies of the GG genotype of SNP rs7873784 in TLR4 (OR = 2.136; 95% CI: 1.312-3.478) and the CC genotype of rs3764879 in TLR8 (OR = 1.982; 95% CI: 1.292-3.042) were also significantly higher in the PTB group than in the HC group.
|
25928077 |
2015 |