|
rs113488022
|
|
Gastrointestinal Stromal Tumors
|
|
0.800 |
GeneticVariation
|
BEFREE |
We identified BRAF V600E</span> point mutation in 4 % of KIT/PDGFRA wild-type GIST patients.
|
31708372 |
2019 |
|
rs113488022
|
|
Gastrointestinal Stromal Tumors
|
|
0.800 |
GeneticVariation
|
BEFREE |
Sorafenib-responsive GISTs were BRAF wild-type, whereas the sorafenib-resistant GIST carried a BRAF V600E mutation.
|
30179868 |
2019 |
|
rs113488022
|
|
Gastrointestinal Stromal Tumors
|
|
0.800 |
GeneticVariation
|
BEFREE |
GISTs with the BRAF V600E mutation are relatively benign tumors with a distinctive molecular mechanism.
|
28034324 |
2017 |
|
rs113488022
|
|
Gastrointestinal Stromal Tumors
|
|
0.800 |
GeneticVariation
|
BEFREE |
BRAF V600E mutation-specific immunohistochemistry is a highly sensitive and specific method for detecting BRAF-mutated GISTs.
|
26486743 |
2015 |
|
rs113488022
|
|
Gastrointestinal Stromal Tumors
|
|
0.800 |
GeneticVariation
|
BEFREE |
The aims of this study were to investigate whether succinate dehydrogenase B (SDHB), insulin growth factor 1 receptor (IGF1R), HER2, epidermal growth factor receptor (EGFR) and/or BRAF V600E immunohistochemistry could screen for wild-type gastrointestinal stromal tumours (GISTs), and to determine what proportion of wild-type GISTs expressed these proteins and might therefore represent candidates for targeted therapies.
|
25659413 |
2015 |
|
rs113488022
|
|
Gastrointestinal Stromal Tumors
|
|
0.800 |
GeneticVariation
|
BEFREE |
The BRAF(V600E) melanoma mutation, like the KIT exon 11 mutation in GIST, has the highest response to therapy.
|
24531699 |
2014 |
|
rs113488022
|
|
Gastrointestinal Stromal Tumors
|
T |
0.800 |
CausalMutation
|
CLINVAR |
We report prolonged antitumor activity in the first patient with V600E BRAF-mutated GIST who was treated with a BRAF inhibitor.
|
23470635 |
2013 |
|
rs113488022
|
|
Gastrointestinal Stromal Tumors
|
|
0.800 |
GeneticVariation
|
BEFREE |
We report prolonged antitumor activity in the first patient with V600E BRAF-mutated GIST who was treated with a BRAF inhibitor.
|
23470635 |
2013 |
|
rs113488022
|
|
Gastrointestinal Stromal Tumors
|
|
0.800 |
GeneticVariation
|
BEFREE |
We constructed tissue microarrays of formalin-fixed and paraffin-embedded specimens of 534 gastroesophageal tumors (119 squamous cell cancers and 72 adenocarcinomas of the esophagus, 63 cancers of the gastroesophageal junction/cardia, 199 gastric cancers of the corpus or antrum, 81 gastric gastrointestinal stromal tumors) and performed anti-BRAF-V600E immunostaining using the mutation-specific antibody VE1.
|
23343956 |
2013 |
|
rs113488022
|
|
Gastrointestinal Stromal Tumors
|
T |
0.800 |
CausalMutation
|
CLINVAR |
Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial.
|
22608338 |
2012 |
|
rs113488022
|
|
Gastrointestinal Stromal Tumors
|
T |
0.800 |
CausalMutation
|
CLINVAR |
Improved survival with vemurafenib in melanoma with BRAF V600E mutation.
|
21639808 |
2011 |
|
rs113488022
|
|
Gastrointestinal Stromal Tumors
|
T |
0.800 |
CausalMutation
|
CLINVAR |
Inhibition of mutated, activated BRAF in metastatic melanoma.
|
20818844 |
2010 |
|
rs113488022
|
|
Gastrointestinal Stromal Tumors
|
|
0.800 |
GeneticVariation
|
BEFREE |
BRAF V600E detection in the tumor does not induce a higher expression of the B-raf protein or the preferential activation of the p42/44 mitogen-activated protein kinase (MAPK) signaling pathway compared with GISTs without the BRAF mutation.
|
20023270 |
2010 |
|
rs113488022
|
|
Gastrointestinal Stromal Tumors
|
|
0.800 |
GeneticVariation
|
BEFREE |
BRAF mutations (V600E) were detected in 2 of 28 wild-type GISTs (7%), but in none of the 41 KIT/PDGFRA mutants.No KRAS mutation was detected.
|
19561230 |
2009 |
|
rs113488022
|
|
Gastrointestinal Stromal Tumors
|
T |
0.800 |
CausalMutation
|
CLINVAR |
BRAF mutations (V600E) were detected in 2 of 28 wild-type GISTs (7%), but in none of the 41 KIT/PDGFRA mutants.No KRAS mutation was detected.
|
19561230 |
2009 |
|
rs113488022
|
|
Gastrointestinal Stromal Tumors
|
|
0.800 |
GeneticVariation
|
BEFREE |
An identical V600E BRAF mutation was also identified in one of 28 imatinib resistant GIST lacking a defined mechanism of drug resistance.
|
18615679 |
2008 |
|
rs113488022
|
|
Gastrointestinal Stromal Tumors
|
T |
0.800 |
CausalMutation
|
CLINVAR |
Mutations of the BRAF gene in human cancer.
|
12068308 |
2002 |