Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800795
rs1800795
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE The C allele of rs1800795 was associated with PCa risk in the assessed population (OR (95% CI) = 1.45 (1.06-1.98)). 30345492

2019

dbSNP: rs1800795
rs1800795
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE Nevertheless, in the subgroup analysis by ethnicity, we identified that <i>IL-6</i>-rs1800795 polymorphism was associated with an increased risk of PCa for Caucasian individuals in dominant model (MM + MW vs. WW: OR = 1.245, 95%CI = 1.176-1.318, <i>P</i> < 0.001). 30854108

2019

dbSNP: rs1800795
rs1800795
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE The Role of Interleukin-6 Polymorphism (rs1800795) in Prostate Cancer Development and Progression. 29848725

2018

dbSNP: rs1800795
rs1800795
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE Overall estimates revealed no significant relationship between IL-6 rs1800795 polymorphism and prostate cancer risk in total analysis, but a risk-increasing effect of the polymorphism was detected in African-American subgroup under CC versus GG and CC versus GG + GC contrasts (OR 3.43, 95% CI 1.01-11.71; OR 3.51, 95% CI 1.04-11.82) after subgroup analysis by ethnicity.IL-6 rs1800795 polymorphism may enhance the susceptibility to prostate cancer in African-American men. 28296724

2017

dbSNP: rs1800795
rs1800795
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE We investigated the role of two functional polymorphisms, IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796), in the development of prostate cancer. 26535651

2015

dbSNP: rs1800795
rs1800795
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE Direct sequencing of the PCR amplicon from genomic DNA was used for genotyping rs1800795 in all subjects [age-matched controls (N = 140) and prostate cancer patients (N = 164)]. 24446297

2014

dbSNP: rs1800795
rs1800795
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation. 19267250

2009