Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs762846821
rs762846821
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.040 GeneticVariation BEFREE Co-expression of Nm23H1 but not H2 in NIH3T3 cells effectively suppressed neoplastic transformation and tumorigenesis induced by the oncogenic H-Ras G12V mutant. 25748386

2015
dbSNP: rs762846821
rs762846821
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.040 GeneticVariation BEFREE These results suggest that tsTAg synergistically promotes Kras(G12D) -associated PDAC formation, and our study identifies a new mouse model of PDAC that may allow a better understanding of the mechanism of carcinogenesis in pancreatic carcinoma, which shows a catastrophic clinical course. 25042889

2014
dbSNP: rs762846821
rs762846821
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.040 GeneticVariation BEFREE Kras(G12D); IL-6(-/-) mice exhibited increased tumorigenesis, but slower tumor growth and longer survival, than Kras(G12D) mice. 24260500

2013
dbSNP: rs762846821
rs762846821
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.040 GeneticVariation BEFREE The effect of NO-aspirin on pancreatic carcinogenesis was investigated by assessing the development of precursor pancreatic lesions and adenocarcinomas in Kras(G12D/+) transgenic mice that recapitulate human pancreatic cancer progression. 23019409

2012