Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE MicroRNAs (miRNAs) miRNA-499 rs3746444 A>G polymorphism may be complicated in the susceptibility to cancer. 31496728

2019

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE MicroRNA-499 rs3746444 was found to be significantly associated with increased risk of cancer of the respiratory system (CC vs. TT: OR = 1.575, 95% CI = 1.268-1.955, CC vs. TC+TT: OR = 1.527, 95% CI = 1.232-1.892), digestive system (CC vs. TT: OR = 1.153, 95% CI = 1.027-1.295; TC vs. TT: OR = 1.109, 95% CI = 1.046-1.176; CC+TC vs. TT: OR = 1.112, 95% CI = 1.018-1.216; CC vs. TC+TT: OR = 1.137, 95% CI = 1.016-1.272; C vs. T: OR = 1.112, 95% CI = 1.025-1.206), urinary system (TC vs. TT: OR = 1.307, 95% CI = 1.130-1.512; CC+TC vs. TT: OR = 1.259, 95% CI = 1.097-1.446; C vs. T: OR = 1.132, 95% CI = 1.014-1.264), and gynecological system (C vs. T: OR = 1.169, 95% CI = 1.002-1.364). 29946268

2018

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE Our meta-analysis suggests that the rs11614913 most likely contributes to decreased susceptibility to cancer, especially in Asians and colorectal cancer and gastric cancer, and that the rs3746444 may increase risk for cancer. 29371991

2017

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE Thus, we aimed to investigate the association of MIR196a2 rs11614913 (C/T), MIR499a rs3746444 (A/G) polymorphisms and their combination with cancer susceptibility in an Egyptian population. 27509977

2016

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE We further performed functional studies of three microRNA variants associated with cancer (rs2910164:C > G in MIR146A, rs11614913:C > T in MIR196A2, and rs3746444:A > G in both MIR499A and MIR499B). 27397105

2016

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE In conclusion, our meta-analysis suggests that hsa-mir-499 rs3746444 A>G polymorphism is not associated with risk of cancer</span> based on current evidence. 25640376

2015

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE Multivariate survival analysis using the Cox's regression model revealed that non-responder by the RECIST (Hazard ratio (HR): 2.14 95%CI 1.06-4.19), upper third cancer (HR: 2.48 95%CI 1.12-5.49) and more advanced stage (HR: 4.12 95%CI 1.06-16.02) were predictive factors for worse OS, while the rs3746444 A allele carrier was predictive factor for better OS (HR: 0.33 95%CI 0.18-0.75). 25202115

2014

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE A recent study indicates that inflammation and abnormal immune responses may promote malignant progression in cancer development, indicating that inflammation-related polymorphisms such as miR-146a rs2910164 and miR-499 rs3746444 are crucial. 25108400

2014

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE In the subgroup analysis by cancer types, no risk of breast, liver, or lung cancers were found significantly associated with microRNA-499 rs3746444 A/G polymorphism in any of the genetic models. 24258110

2014

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE Our meta-analysis suggested that hsa-mir-499 rs3746444 T > C polymorphism is associated with the risk of cancer in Asians, mainly in Iranian and Chinese population. 25433484

2014

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE These findings indicate that the miR-499 rs3746444 polymorphism is associated with an increased cancer risk. 24085457

2013

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE There were not significant associations between miR-146a rs2910164 and miR-499 rs3746444 polymorphisms with overall cancer risk. 23292097

2013

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE 35, 95% CI: 1.09-1.67), and rs3746444 was associated with liver cancer in the subgroup of cance</span>r types. 23725137

2013

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE Whereas, rs3746444 G allele was a risk factor in Chinese population, and the association varied from different cancer types. 23750236

2013

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE Our findings support the view that miR-499 rs3746444 T>C polymorphism is associated with breast cancer and the C allele can increase cancer susceptibility in Asian. 23271127

2013

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE In summary, miR-196a2 rs11614913, miR-146a rs2910164, and miR-499 rs37</span>46444 are risk factors for cancer development, whereas mir-149 rs2292832 and miR-27a rs895919 are not associated with cancer risk. 24278149

2013

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE It is concluded that two SNPs prsent in miRNAs(rs11614913TT, and rs2910164C) may protect against the pathogenesis of some cancers, and that the rs3746444 may increase risk for cancer. 23155448

2012

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE These meta-analysis results suggest that hsa-miR-499 polymorphism rs3746444 is associated with a significantly increased risk of cancer, especially in Asian populations. 23236400

2012

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE In conclusion, this meta-analysis suggests that the miR-499 rs3746444 polymorphism (A>G) is a low-penetrant risk factor for cancer development among Asians and may contribute to breast cancer susceptibility. 23053947

2012

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE Overall, hsa-miR-499 rs3746444 polymorphism was associated with higher cancer risk in heterozygote model (AG vs AA, OR=1.15, 95%CI=1.01-1.30, P(heterogeneity)<0.001), dominant genetic model (GG/AG vs AA, OR=1.18, 95% CI=1.04-1.33, P(heterogeneity)<0.001) and allele contrast (G vs A, OR=1.09, 95% CI=1.01-1.18, P(heterogeneity)=0.021). 22922391

2012

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE The present study was aimed to investigate the association between four highly studied miRNA polymorphisms (mir-146a rs2910164, mir-196a2 rs11614913, mir-149 rs2292832 and mir-499 rs3746444) and cancer risk by using a two-sided meta-analytic approach. 23226435

2012

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE This meta-analysis suggests a significant association between miR-499 rs3746444 polymorphism and cancer risk. 22970328

2012

dbSNP: rs3746444
rs3746444
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE Here, we evaluated 101 paired samples (cancer and normal tissues) from non-small cell lung carcinoma (NSCLC) patients to study the genotype distribution of single nucleotide polymorphisms (SNPs) in miR-146a (rs2910164 C-G), miR-149 (rs2292832 C-T), miR-196a2 (rs11614913 C-T) and miR-499 (rs3746444 G-A) and their influence on the expression of respective miRNAs. 21902575

2011