|
rs854560
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, this meta-analysis proved that PON1 rs854560 polymorphism could be used to identify individual with elevated susceptibility to IS, whereas rs662 polymorphism could be used to identify individual with elevated susceptibility to CAD.
|
31302193 |
2019 |
|
rs854560
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the rs854560 polymorphism may modulate the risk of CAD in response to cigarette smoking in Polish population.
|
29118461 |
2017 |
|
rs854560
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
It was thought that the PON1 gene L55M polymorphism plays a significant role in CAD progression, especially in females.
|
26467378 |
2016 |
|
rs854560
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The activity of PON1 is decreased in patients with coronary artery disease, myocardial infarction or chronic kidney disease. rs662 and rs854560 are single nucleotide polymorphisms (SNPs) associated with PON1 activity and 10-year cardiovascular mortality of patients with stable coronary artery disease.
|
25155309 |
2016 |
|
rs854560
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
rs4769874 (ALOX5AP), rs854560 (PON1), and rs4646903 (CYP1A1 MspI polymorphism) are significantly associated with an increased risk of CAD with respective odds ratios of 1.53703, 1.67710, and 1.35520; the genetic variant rs9579646 (ALOX5AP) is significantly associated with a decreased risk of CAD (OR 0.76163).
|
25902778 |
2015 |
|
rs854560
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In view of the reported association of SNPs in the paraoxonase (PON1) gene with coronary artery disease (CAD), and the absence of conclusive data from India, we investigated the relationship of three SNPs at different loci (-108C/T, L55M and Q192R) of the PON1 gene and their haplotypes with CAD among people residing in the northern plains of India.
|
22750797 |
2012 |
|
rs854560
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Only PON1 L55M (MM) genotype frequency was significantly higher in CAD patients than in controls (P<0.05), while its frequency was similar between the two subgroups according to CAD severity.
|
19269283 |
2009 |
|
rs854560
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, our results suggest that there is an association between the PON 1 L/M 55 polymorphism of paraoxonase and CAD in Turkish patients but not with PON 1 Q/R 192 polymorphism.
|
19226538 |
2009 |
|
rs854560
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We evaluated the risk of CAD associated with PON1 Q192R and L55M polymorphisms in 298 CAD patients and 298 healthy individuals.
|
19280995 |
2008 |
|
rs854560
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Multiple regression analysis disclosed smoking, a family history of CAD, high-density lipoprotein (HDL)-cholesterol and the PON1 M/L55 mutation [OR=0.59 (CI95%: 0.42-0.82); p=0.002] as independent markers for CAD.
|
14996478 |
2004 |
|
rs854560
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Three polymorphisms in the PON1 (Leu55Met and Gln192Arg) and PON2 (Ser311Cys) genes have been shown to be associated with the risk of CAD in several European or European-derived populations.
|
12454802 |
2003 |
|
rs854560
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotype distributions and allele frequencies of M/L55 and C/S311 were similar among the control and patient groups, whereas the R192 allele frequency was significantly higher (P<0.001) in CAD (75%) and ischemic stroke (76%) patients than in control subjects (65%).
|
10729395 |
2000 |