Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11874392
rs11874392
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.730 GeneticVariation BEFREE As partial validation of our approach, a known CRC risk variant in SMAD7 (in both the TGF-β and WNT pathways: rs11874392) was associated with CRC risk in our data. 29986644

2018
dbSNP: rs11874392
rs11874392
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.730 GeneticVariation BEFREE Additionally, gene-smoking interactions for rs11874392, rs10988706 and rs6478972 were also found to enhance the risk of CRC at both stages, with P for multiplicative interaction equal to 1.162×10(-6), 8.574×10(-8) and 9.410×10(-8) in combined analyses, respectively. 23275154

2013
dbSNP: rs11874392
rs11874392
SMAD7
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.730 GeneticVariation BEFREE Among the population-based families, both SNPs rs12953717 (odds ratio, 1.29; 95% confidence interval, 1.12-1.49), and rs11874392 (odds ratio, 0.80; 95% confidence interval, 0.70-0.92) were associated with risk of colorectal cancer. 23560096

2013