|
rs12953717
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The dominant model of SMAD7 rs12953717 (CT + TT genotypes) significantly increased CRC risk (HR=2.17, 95% CI=1.12-4.16) when compared to the wild-type CC genotype.
|
30275229 |
2018 |
|
rs12953717
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
For SNPs on 18q21 (rs12953717 and rs4464148) and 20q13 (rs4925386), alleles that correlate with higher risk for the development of CRC are associated with shorter disease free survival (DFS).
|
29119627 |
2018 |
|
rs12953717
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Subgroup analysis according to ethnicity showed rs4464148 and rs12953717 were associated with the risk of CRC in bo</span>th Caucasians and Asians, whereas rs4939827 was a risk polymorphism for CRC specifically in Caucasians.
|
28070019 |
2016 |
|
rs12953717
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
On the other hand, rs12953717 T allele showed a statistically significant association with CRC risk (adjusted OR=1.339, 95% CI: 1.017-1.764, p=0.037).
|
25640388 |
2015 |
|
rs12953717
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
For SMAD7 gene, rs4939827 and rs4464148 are risk factors for CRC among Caucasian whereas rs12953717 could elevate the susceptibility to CRC in both Caucasian and Asian.
|
26579801 |
2015 |
|
rs12953717
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
When stratifying for race, the data showed that the rs12953717</span> was associated with a significantly increased CRC risk under all genetic models in Caucasians.
|
23949881 |
2014 |
|
rs12953717
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In the subgroup analysis by cancer types, SMAD7 rs12953717 polymorphism was significantly associated with colorectal cancer.
|
23472153 |
2013 |
|
rs12953717
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Among the population-based families, both SNPs rs12953717 (odds ratio, 1.29; 95% confidence interval, 1.12-1.49), and rs11874392 (odds ratio, 0.80; 95% confidence interval, 0.70-0.92) were associated with risk of colorectal cancer.
|
23560096 |
2013 |
|
rs12953717
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Two previous genome-wide association studies identified three single nucleotide polymorphisms (SNPs) (rs4939827, rs12953717 and rs4464148) in SMAD7 to be associated with colorectal cancer in a Western population.
|
21221812 |
2011 |
|
rs12953717
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Two recent genome-wide association studies (GWAS) identified three common variants in SMAD7 (rs4464148, rs4939827 and rs12953717) that confer modest susceptibility to colorectal cancer.
|
19357349 |
2009 |
|
rs12953717
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently we have demonstrated variation in SMAD7, defined by the single nucleotide polymorphism rs12953717, to be strongly associated with risk of colorectal cancer.
|
18231913 |
2008 |