Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs16969681
rs16969681
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.720 GeneticVariation BEFREE The intestine-specific transcription factor CDX2 and Wnt effector TCF7L2 bound near rs16969681, with significantly higher affinity for the risk allele, and CDX2 overexpression in CDX2/GREM1-negative cells caused re-expression of GREM1. rs16969681 influences CRC risk through effects on Wnt-driven GREM1 expression in colorectal tumors. 25131200

2014
dbSNP: rs16969681
rs16969681
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.720 GeneticVariation BEFREE Near GREM1, we found using fine-mapping that the previously-identified association between tagSNP rs4779584 and CRC actually resulted from two independent signals represented by rs16969681 (P = 5.33×10(-8)) and rs11632715 (P = 2.30×10(-10)). 21655089

2011