Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4779584
rs4779584
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.870 GeneticVariation BEFREE We confirmed the association of CRC risk with four SNPs, with odds ratio (OR) higher than previously reported: rs16892766 on 8q23.3 (OR: 1.88, 95% confidence interval (CI): 1.30-2.72; P=0.0007); rs4779584 on 15q13.3 (OR: 1.42, CI: 1.11-1.83; P=0.0061) and rs4939827 and rs58920878/Novel 1 on 18q21.1 (OR: 1.49, CI: 1.13-1.98; P=0.007 and OR: 1.49, CI: 1.14-1.95; P=0.0035). 25873010

2016

dbSNP: rs4779584
rs4779584
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.870 GeneticVariation BEFREE This meta-analysis demonstrated that the rs4779584 and rs10318 polymorphism at 15q13.3 is a risk factor associated with increased CRC/CRA susceptibility, but these associations vary in different ethnic populations. 25475391

2015

dbSNP: rs4779584
rs4779584
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.870 GeneticVariation BEFREE rs4939827, rs4779584, and rs10795668 may contribute to the risk of CRC in the Korean population as well as in European populations. 23875689

2015

dbSNP: rs4779584
rs4779584
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.870 GeneticVariation BEFREE GREM1-SCG5 rs4779584 polymorphisms may increase the risk of developing colorectal cancer. 24586997

2014

dbSNP: rs4779584
rs4779584
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.870 GeneticVariation BEFREE We used meta-analysis of an efficient empirical-Bayes estimator to detect potential multiplicative interactions between each of the SNPs [rs16892766 at 8q23.3 (EIF3H/UTP23), rs6983267 at 8q24 (MYC), rs10795668 at 10p14 (FLJ3802842), rs3802842 at 11q23 (LOC120376), rs4444235 at 14q22.2 (BMP4), rs4779584 at 15q13 (GREM1), rs9929218 at 16q22.1 (CDH1), rs4939827 at 18q21 (SMAD7), rs10411210 at 19q13.1 (RHPN2), and rs961253 at 20p12.3 (BMP2)] and select major CRC risk factors (sex, body mass index, height, smoking status, aspirin/nonsteroidal anti-inflammatory drug use, alcohol use, and dietary intake of calcium, folate, red meat, processed meat, vegetables, fruit, and fiber). 22367214

2012

dbSNP: rs4779584
rs4779584
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.870 GeneticVariation BEFREE Near GREM1, we found using fine-mapping that the previously-identified association between tagSNP rs4779584 and CRC actually resulted from two independent signals represented by rs16969681 (P = 5.33×10(-8)) and rs11632715 (P = 2.30×10(-10)). 21655089

2011

dbSNP: rs4779584
rs4779584
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.870 GeneticVariation BEFREE In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)). 18084292

2008