rs4938723
|
|
Colorectal Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
These findings indicate that the miR-34b/c rs4938723T > C polymorphism is an independent variable and associated with a decreased risk of CRC in Chinese population.
|
31349954 |
2019 |
rs4938723
|
|
Colorectal Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
CONCLUSIONS Current meta-analysis suggested that rs4938723 polymorphism was potentially associated with hepatocellular carcinoma risk, but this polymorphism had a decreased association for susceptibility to esophageal cancer, leukemia, and colorectal cancer.
|
30286050 |
2018 |
rs4938723
|
|
Colorectal Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
After stratifying by ethnicity and cancer type, genotype CT of rs4938723 was significantly association with an increased cancer risk in Asian population (P(h)=0.187, OR=1.10, 95%CI=1.01-1.20), allele C and genotype CT were significantly positive associated with hepatocellular cancer (P(h)=0.113, OR=1.11, 95%CI=1.01-1.23 for C vs. T; P(h)=0.121, OR=1.19, 95%CI=1.03-1.37 for CT vs. TT), but rs4938723 was negative associated with risk of colorectal cancer (P(h)=0.342, OR=0.66, 95%CI=0.47-0.92 for CC vs. TT; P(h)=0.519, OR=0.67, 95%CI=0.49-0.93 for CC vs. CT/TT; P(h)=0.443, OR=0.71, 95%CI=0.51-0.99 for CC/TT vs. CT).
|
25475831 |
2015 |
rs4938723
|
|
Colorectal Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
The current meta-analysis indicated that the miR-34b/c rs4938723 polymorphism may decrease susceptibility to colorectal cancer.
|
25227823 |
2014 |
rs4938723
|
|
Colorectal Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
The SNP rs4938723 and diabetes mellitus (DM) together were associated with an increased CRC risk, but the SNP TP53 Arg72Pro CC with DM showed a protective effect against CRC.
|
24337371 |
2014 |
rs4938723
|
|
Colorectal Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
This rs4938723 SNP showed an opposite tendency orientation between the hepatocellular cancer and colorectal cancer risks.
|
25201061 |
2014 |
rs4938723
|
|
Colorectal Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
These findings indicate that the rs4938723 in the promoter region of pri-miR-34b/c was a protective factor for the development of CRC.
|
23183747 |
2013 |