Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2252586
rs2252586
CUI: C0017638
Disease: Glioma
Glioma
0.860 GeneticVariation BEFREE In conclusion, this meta-analysis found that EGFR rs2252586 mutation was significantly associated with glioma risk. 29208187

2017

dbSNP: rs2252586
rs2252586
CUI: C0017638
Disease: Glioma
Glioma
0.860 GeneticVariation BEFREE However, no significant association was observed between rs12718945/rs17172432/rs4947492 and glioma risk in Asians, between rs2252586 and glioma risk in Caucasians, and between rs3752651 and glioma risk in either Asians or Caucasians. 29156842

2017

dbSNP: rs2252586
rs2252586
CUI: C0017638
Disease: Glioma
Glioma
0.860 GeneticVariation BEFREE Results showed that seven hot loci were all associated with increased risk of glioma (rs2736100, OR = 1.28, 95 %CI = 1.23-1.32; rs4295627, OR = 1.34, 95 %CI = 1.21-1.47; rs4977756, OR = 1.24, 95 %CI = 1.20-1.28; rs498872, OR = 1.24, 95 %CI = 1.15-1.33; rs6010620, OR = 1.29, 95 %CI = 1.24-1.35; rs11979158: OR = 1.18, 95 %CI = 1.10-1.25; rs2252586: OR = 1.18, 95 %CI = 1.10-1.25). 26243184

2016

dbSNP: rs2252586
rs2252586
CUI: C0017638
Disease: Glioma
Glioma
0.860 GeneticVariation BEFREE Genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) at 7 loci influencing glioma risk: rs2736100 (TERT), rs11979158 and rs2252586 (EGFR), rs4295627 (CCDC26), rs4977756 (CDKN2A/CDKN2B), rs498872 (PHLDB1), and rs6010620 (RTEL1). 23161787

2013

dbSNP: rs2252586
rs2252586
CUI: C0017638
Disease: Glioma
Glioma
0.860 GeneticVariation BEFREE Seven independent chromosomal loci have robustly been associated with glioma risk: 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1), and two loci at 7p11.2 (rs11979158 and rs2252586, EGFR). 21825990

2011

dbSNP: rs2252586
rs2252586
CUI: C0017638
Disease: Glioma
Glioma
0.860 GeneticVariation BEFREE Using these data, we demonstrate two statistically independent associations between glioma and rs11979158 and rs2252586, at 7p11.2 which encompasses the EGFR gene (population-corrected statistics, P(c) = 7.72 × 10(-8) and 2.09 × 10(-8), respectively). 21531791

2011