|
rs3748067
|
|
Malignant neoplasm of stomach
|
|
0.080 |
GeneticVariation
|
BEFREE |
The pooled estimate revealed an association between IL-17A rs2275913 polymorphism and the risk of GC under all genetic models (A vs. G, OR 1.187, 95% CI 1.086-1.297, P < 0.001; GA vs. GG, OR 1.108, 95% CI 1.008-1.218, P = 0.033; AA vs. GG, OR 1.484, 95% CI 1.236-1.781, P < 0.001), while no evidence of association was found with IL-17A rs3748067 or IL-17F rs763780 polymorphisms.
|
29860554 |
2018 |
|
rs3748067
|
|
Malignant neoplasm of stomach
|
|
0.080 |
GeneticVariation
|
BEFREE |
We found that CT (OR<sub>adj</sub> = 0.59; 95% CI: 0.44-0.79), CT + TT (OR<sub>adj</sub> = 0.58; 95% CI: 0.43-0.77) genotypes, and T allele (OR<sub>adj</sub> = 0.77; 95% CI: 0.47-0.80) of rs3748067 reduced GC risk; the rs10889677 CC genotype (OR<sub>adj</sub> = 2.22; 95% CI: 1.27-3.87) and C allele (OR<sub>adj</sub> = 1.24; 95% CI: 1.02-1.52) increased GC risk.
|
29118466 |
2017 |
|
rs3748067
|
|
Malignant neoplasm of stomach
|
|
0.080 |
GeneticVariation
|
BEFREE |
In conclusion, our results suggest that the IL-17A rs3748067C>T and IL-17F rs763780 T>C polymorphisms play an important role in the risk of gastric cancer in a Chinese population.
|
26535650 |
2015 |
|
rs3748067
|
|
Malignant neoplasm of stomach
|
|
0.080 |
GeneticVariation
|
BEFREE |
The rs2275913 AA (adjusted OR = 1.69, 95 % CI = 1.15-2.49) and rs3748067 TT (adjusted OR = 1.73, 95 % CI = 1.03-2.94) genotypes were associated with an increased risk of gastric cancer.
|
24218334 |
2014 |
|
rs3748067
|
|
Malignant neoplasm of stomach
|
|
0.080 |
GeneticVariation
|
BEFREE |
These results suggest that rs2275913 and rs3748067 variations significantly increase gastric cancer risk in a Chinese population.
|
25012243 |
2014 |
|
rs3748067
|
|
Malignant neoplasm of stomach
|
|
0.080 |
GeneticVariation
|
BEFREE |
A significant interaction was observed between the rs2275913G>A and rs3748067C>T genotype and subsites of gastric cancer (p for interaction of 0.044 and 0.008, respectively).
|
24218334 |
2014 |
|
rs3748067
|
|
Malignant neoplasm of stomach
|
|
0.080 |
GeneticVariation
|
BEFREE |
However, no significant positive signals were observed in the association analysis of the rs3748067 and rs763780 polymorphisms with the risk of gastric cancer in IL-17A and IL-17F, respectively.
|
25374195 |
2014 |
|
rs3748067
|
|
Malignant neoplasm of stomach
|
|
0.080 |
GeneticVariation
|
BEFREE |
In addition, rs2275913, rs3748067 and rs9382084 genetic variants were only associated with non-cardia gastric cancer.
|
24315816 |
2014 |
|
rs3748067
|
|
Malignant neoplasm of stomach
|
|
0.080 |
GeneticVariation
|
BEFREE |
The rs3748067 T polymorphism was associated with a decreased risk for intestinal GC (OR, 0.511; 95%CI, 0.272-0.962; p = 0.037), whereas rs2505901 C locus carried a decreased risk overall for GC (OR, 0.733; 95%CI, 0.545-0.985; p = 0.039).
|
22537748 |
2012 |