|
rs751402
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |
|
rs751402
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis indicates that the XPG rs751402 polymorphism may be a risk factor for GC in the Chinese population.
|
29148016 |
2018 |
|
rs751402
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current meta-analysis demonstrated that the XPG gene polymorphism rs751402 was associated with increased susceptibility to gastric cancer in Chinese populations.
|
29049208 |
2017 |
|
rs751402
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
The XPG gene rs751402 polymorphism is associated with an increased risk of GC in Chinese Han populations.
|
28832189 |
2017 |
|
rs751402
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a stratified analysis, rs1047768 T>C was associated with an increased risk of lung cancer, rs2227869 G>C was associated with a decreased risk of cancer in population-based studies, and rs751402 C>T and rs873601 G>A were associated with the risk of gastric cancer.
|
28416771 |
2017 |
|
rs751402
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, we observed strong correlation between rs751402 polymorphism and gastric cancer (C vs T: OR=1.21, 95% CI = 1.00-1.26, P = .045; TC vs CC: OR = 1.12, 95% CI = 1.00-1.24, P = .041; TC/TT vs CC: OR = 1.13, 95% CI = 1.02-1.26, P = .020).
|
28796034 |
2017 |
|
rs751402
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conducted a case-control study to assess the association between single nucleotide polymorphisms in the ERCC5 promoter (rs2094258 and rs751402) and development of gastric cancer in a Chinese population.
|
27323158 |
2016 |
|
rs751402
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, we did not observe a significant association between XPG rs2094258 and rs751402 polymorphisms and development of gastric cancer.
|
27323165 |
2016 |
|
rs751402
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, in a dominant model, the CG + GG genotype of rs17655 was correlated with an increased risk of gastric cancer compared to the CC genotype (OR = 1.48; 95%CI = 1.00-2.22). rs1047768 and rs751402 were not significantly correlated with an increased or decreased gastric cancer risk.
|
27051028 |
2016 |
|
rs751402
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, unconditional multiple logistic regression analysis revealed that the AA genotype of rs751402 sign</span>ificantly increased gastric cancer risk compared to the GG genotype [odds ratio (OR) = 2.61, 95%CI = 1.23-5.49; P = 0.005].
|
27323183 |
2016 |
|
rs751402
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
By unconditional logistic regression analysis, we</span> observed that the TT genotype in rs751402</span> was significantly associated with increased risk to gastric cancer as compared with the CC genotype, and the adjusted OR (95%CI) was 2.17 (1.15-4.09).
|
27706622 |
2016 |
|
rs751402
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic effects on increased GC risk seemed to be enhanced by Helicobacter pylori infection, smoking and alcohol drinking, with corresponding adjusted ORs of 4.57, 2.42 and 2.50 for the rs751402 AG/AA variants, and of 5.32, 3.20 and 6.87 for the rs2296147 CC variant, but their interaction effects on GC risk didn't reach statistically significance.
|
22982416 |
2012 |