Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4986790
rs4986790
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.040 GeneticVariation BEFREE All polymorphisms detected were also significantly associated with the metastatic disease (p<0.001) leading to shorter overall survival (p<0.001); whereas, TLR4 Asp299Gly and Thr399Ile polymorphisms were significantly associated with KRAS mutations. 29883450

2018

dbSNP: rs4986790
rs4986790
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.040 GeneticVariation BEFREE Finally, we observed a positive link between D299G and T399I polymorphisms and CRC patients with lymph node (p = 0.00024; p = 0.0005, respectively) and metastasis (p = 0.001; p = 0.002, respectively). 23949880

2014

dbSNP: rs4986790
rs4986790
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.040 GeneticVariation BEFREE Human colon adenocarcinomas from patients with TLR4-D299G were more frequently of an advanced stage (International Union Against Cancer [UICC] ≥III, 70% vs 46%; P = .0142) with metastasis (UICC IV, 42% vs 19%; P = .0065) than those with wild-type TLR4. 21920464

2011

dbSNP: rs4986790
rs4986790
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.040 GeneticVariation BEFREE An improved overall survival (Hazard ratio HR 0.53, 95% CI 0.32-0.88) and survival following metastasis (HR 0.55, 95% CI 0.34-0.91) were observed in carriers of the variant allele (D299G) of TLR4-rs4986790. 21931695

2011