Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs762846821
rs762846821
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.040 GeneticVariation BEFREE Orthotopic implantation of PDCs carrying the activated Kras(G12D)-allele and shRNA against p16(Ink4a) or Trp53 resulted in tumor growth, metastasis, and reduced survival of NSG mice. 25724428

2015

dbSNP: rs762846821
rs762846821
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.040 GeneticVariation BEFREE Further, in order to investigate whether IL-6 deletion contributes to suppression of lung cancer metastasis, we generated Kras(G12D); p53(flox/flox); IL-6(-/-) mice, which developed lung cancer with a trend for reduced metastases and longer survival than Kras(G12D); p53(flox/flox) mice. 24260500

2013

dbSNP: rs762846821
rs762846821
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.040 GeneticVariation BEFREE Latency was shortened by combining Kras(G12D) activation with heterozygous or homozygous deletion of p53 (mean survival of 56 weeks vs. 19 weeks, respectively), which also resulted in widespread local and distant metastasis. 22266220

2012

dbSNP: rs762846821
rs762846821
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.040 GeneticVariation BEFREE In summary, by using 'knock-in' mutations of Trp53 we have identified two critical acquired functions of a stably expressed mutant form of p53 that drive PDAC; first, an escape from Kras(G12D)-induced senescence/growth arrest and second, the promotion of metastasis. 20018721

2010