Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057519921
rs1057519921
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.020 GeneticVariation BEFREE K-ras<sup>LSL-G12D/+</sup>:: p53<sup>LSL-R172H/+</sup>:: Pdx-1-Cre (KPC) mice are an established model of pancreatic cancer that specifically express mutants of both K-ras and p53 in the pancreas by using Pdx-1-Cre. 28971839

2018

dbSNP: rs1057519921
rs1057519921
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.020 GeneticVariation BEFREE Oncogene-directed increased expression of Nrf2 is a new mechanism for the activation of the Nrf2 antioxidant program, and is evident in primary cells and tissues of mice expressing K-Ras(G12D) and B-Raf(V619E), and in human pancreatic cancer. 21734707

2011