Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913530
rs121913530
KRAS
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.030 GeneticVariation BEFREE This study suggests that the combination of RAF and CDK4/6 inhibitors might be a novel treatment strategy for KRAS G12R mutant pancreatic cancer. 30271501

2018
dbSNP: rs121913530
rs121913530
KRAS
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.030 GeneticVariation BEFREE These effects were tested on MiaPaCa-2 human pancreatic cancer cells carrying a K-Ras activating mutation (G12C) after exposure to individual statins (20 μM). 29262834

2017
dbSNP: rs121913530
rs121913530
KRAS
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.030 GeneticVariation BEFREE Presence of the KRAS G12C mutation had 96% specificity and positive predictive value for lung adenocarcinoma, whereas G12R was 99% specific for pancreatic cancer with a positive predictive value of 86%. 23887294

2014