Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs77375493
rs77375493
CUI: C0280449
Disease: secondary acute myeloid leukemia
secondary acute myeloid leukemia
0.050 GeneticVariation BEFREE Both secondary AML (sAML) from ET and AML with JAK2 V617F mutation have poor prognoses. 29979407

2018

dbSNP: rs77375493
rs77375493
CUI: C0280449
Disease: secondary acute myeloid leukemia
secondary acute myeloid leukemia
0.050 GeneticVariation BEFREE JAK2 V617F-positive acute myeloid leukaemia (AML): a comparison between de novo AML and secondary AML transformed from an underlying myeloproliferative neoplasm. A study from the Bone Marrow Pathology Group. 29767839

2018

dbSNP: rs77375493
rs77375493
CUI: C0280449
Disease: secondary acute myeloid leukemia
secondary acute myeloid leukemia
0.050 GeneticVariation BEFREE Three of the six patients harboring C-CBL mutations at sAML had additional gene mutations including JAK2(V617F), PTPN11, or N-RAS. 22131879

2011

dbSNP: rs77375493
rs77375493
CUI: C0280449
Disease: secondary acute myeloid leukemia
secondary acute myeloid leukemia
0.050 GeneticVariation BEFREE TET2 defects were observed in 15 of 81 patients with myelodysplastic syndromes (19%), in 24 of 198 patients with myeloproliferative disorders (12%) (with or without the JAK2 V617F mutation), in 5 of 21 patients with secondary AML (24%), and in 2 of 9 patients with chronic myelomonocytic leukemia (22%). 19474426

2009

dbSNP: rs77375493
rs77375493
CUI: C0280449
Disease: secondary acute myeloid leukemia
secondary acute myeloid leukemia
0.050 GeneticVariation BEFREE We applied single nucleotide polymorphism arrays (SNP-A) to study karyotypic abnormalities in patients with atypical myeloproliferative syndromes (MPD), including myeloproliferative/myelodysplastic syndrome overlap both positive and negative for the JAK2 V617F mutation and secondary acute myeloid leukemia (AML). 18030353

2007