rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
In particular, both homozygous AA and heterozygous CA genotypes of rs16901979, as well as the AA and CA genotypes of rs1447295, were associated with the risk of prostate cancer.
|
30061842 |
2018 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Therefore, this meta-analysis demonstrated that 8q24 polymorphisms (rs6983267 T>G, rs1447295 C>A, rs16901979 C>A, rs6983561 A>C and rs10090154 C>T) were associated with the susceptibility to PCa, which held the potential biomarkers for PCa risk.
|
29158792 |
2017 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
There are strong association between rs1447295 polymorphism and prostate cancer susceptibility in different ethnic groups and different prostate cancer stage, suggesting that rs1447295 might serve as a reliable biomarker for prostate cancer diagnosis.
|
28978014 |
2017 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
The cumulative effects test of risk alleles (rs rs1983891, rs339331, rs16901966, rs1447295 and rs10090154) showed an increasing risk to PCa in a frequency-dependent manner (ptrend=0.001), and men with more than 3 risk alleles had the most significant susceptibility to PCa (OR=1.99, p=0.001), compared with those who had one risk allele (OR=1.17, p=0.486).
|
26537068 |
2016 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Interestingly, the effect of rs1447295 on PCa risk was observed among Caucasians and Asians, but not Africa-Americans.
|
26159557 |
2015 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
The evidence for 8q24 SNPs with PCa risk in northern Chinese men showed rs16901966, rs1447295 and rs10090154 at 8q24 (region 1, region 2) to be strongly associated with PCa and clinical covariates.
|
24377597 |
2014 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
We showed statistically significant association of the A allele of rs1447295 (OR [CI 95%] = 1.96 [1.37-2.81], P<0.0001) and the T allele of rs10090154 (OR [CI 95%] = 2.14 [1.41-3.26], P<0.0001) with CaP.
|
23628314 |
2014 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
• The frequencies of three CaP risk alleles (rs1447295 [8q24], P= 0.004; rs1571801 [9q33.2], P= 0.03; rs11228565 [11q13], P= 0.02) were significantly higher in men with 'unfavourable' pathological characteristics.
|
22077888 |
2012 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
The A allele at SNP rs1447295 was associated with the incidence of prostate cancer.
|
22583965 |
2012 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
For northern Chinese men rs16901966, rs1447295, rs11986220 and rs10090154 at 8q24 (region 1, region 2) are associated with prostate cancer and prostate cancer related clinical covariates.
|
22099997 |
2012 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
We demonstrate that trans-acting RNA molecules facilitating resistance to androgen depletion (RAD) in vitro and castration-resistant phenotype (CRP) in vivo of PC contain intergenic 8q24-locus SNP variants (rs1447295; rs16901979; rs6983267) that were recently linked with increased risk of PC.
|
22067658 |
2011 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
There was a tendency towards significantly increased risk for SNPs rs1447295 and rs6983267 in men with early-onset prostate cancer.
|
21557270 |
2011 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Correlation between genotypes and biopsy outcome (positive or negative) and Gleason score (≤6 or >6) were studied by univariate and multivariable analysis. rs1447295 and rs6983267 risk variants were found to be associated with the presence of PCa in univariate analysis. rs6983267 genotype remained significantly linked to a positive biopsy (odds ratio [OR] = 1.66, 95% confidence interval [CI]: 1.06-2.59, P = 0.026) in multivariable analysis, but rs1447295 genotype did not (OR = 1.47, 95% CI: 0.89-2.43, P = 0.13).When biopsy outcome was stratified according to Gleason score, risk variants of rs1447295 were associated with aggressive disease (Gleason score ≥7) in univariate and multivariable analysis (OR = 2.05 95% CI: 1.10-3.79, P = 0.023). rs6983267 GG genotype was not related to aggressiveness.
|
21308149 |
2011 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Allele -8 of microsatellite DG8S737 with 22 repeats and allele A of the single-nucleotide polymorphism (SNP) rs1447295 have been found to be significantly associated with prostate cancer.
|
20700145 |
2011 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Analysis of the cumulative risk of rs1447295, a confirmed risk variant, and one of these markers showed that compared to men who do not have any of these risk variants, men who carry any combination of 1 or 2 risk genotypes have a gradually increased prostate cancer risk (P for trend <0.001).
|
19908238 |
2010 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, the relationship between the rs1447295 and DG8S737 polymorphic variants on chromosome 8q24 and prostate cancer risk is seen in the Polish population to a similar degree as it has been observed elsewhere.
|
19952762 |
2010 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Three prostate cancer susceptibility single-nucleotide polymorphisms (rs1447295 at 8q24, rs7920517 and rs10993994 at 10q11) were associated with prostate-specific antigen recurrence (P < 0.02).
|
19900942 |
2009 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our results corroborate previous reports of 8q24 as a prostate cancer susceptibility locus and provide evidence for rs1447295 as a potentially important genetic marker.
|
18625567 |
2009 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Forty-nine tagging SNPs including three previously reported significant variants (rs1447295, rs6983267, rs16901979) and seven variants in the 5' upstream region of the MYC proto-oncogene were tested for association with susceptibility to PC and tumor aggressiveness in 596 histologically verified PC cases and 567 ethnically matched controls.
|
19562729 |
2009 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
This study confirmed that the A allele of rs1447295 is associated with a high risk of PCa in Taiwanese men.
|
19428064 |
2009 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
The A allele of rs1447295 was significantly associated with the risk of sporadic prostate cancer (p = 0.04; age-adjusted OR, 1.34), while the G allele of rs6983267 showed a trend towards being a high-risk allele (p = 0.06; age-adjusted OR, 1.27).
|
19602258 |
2009 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Overall, there was a positive association between carriers of the allele A of rs1447295 and prostate cancer risk [odds ratio (OR), 1.60; 95% confidence interval (95% CI), 1.01-2.52] but no significant association with carriers of alleles A of rs16901979 and allele G of rs6983267.
|
18768513 |
2008 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
The rs1447295 A allele was associated with susceptibility to PC (PC vs. non-PC: P = 0.041; OR, 1.28; 95%CI = 1.01-1.61), and was more significantly associated with disease in aggressive PC (aggressive PC vs. normal controls, P = 0.013; OR, 1.43; 95%CI = 1.08-1.90).
|
18726982 |
2008 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
The rs1447295 marker was strongly associated with prostate cancer among Caucasians (P = 1.23 x 10(-13)).
|
17409400 |
2007 |
rs1447295
|
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
We conclude that the A allele of rs1447295 is associated with a higher risk of prostate cancer regardless of tumor aggressiveness, suggesting that such a variant, or a variant in linkage disequilibrium with it, plays a role early in prostate carcinogenesis.
|
17372260 |
2007 |