rs1217691063
|
|
Carcinogenesis
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that MTHFR C677T polymorphism may play a role in oral cancer carcinogenesis in Asian population and heavy drinkers.
|
24488626 |
2014 |
rs1217691063
|
|
Carcinogenesis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The role of folic acid in carcinogenesis may be modulated by polymorphism C677T in MTHFR and tandem repeats 2R/3R in the promoter site of TYMS gene that are related to decreased enzymatic activity and quantity and availability of the enzyme, respectively.
|
25341694 |
2014 |
rs1217691063
|
|
Carcinogenesis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our pooled data suggest evidence for a major role of MTHFR C677T polymorphism in the carcinogenesis of DLBCL among East Asian populations.
|
23812728 |
2013 |
rs1217691063
|
|
Carcinogenesis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Studies have suggested that genetic polymorphisms of MTHFR (C677T) may clarify the causes and events involved in esophageal carcinogenesis.
|
21951971 |
2012 |
rs1217691063
|
|
Carcinogenesis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the MTHFR 677 C → T and the MTHFR 1298A → C genetic polymorphisms might play important role in hepatic carcinogenesis.
|
21956592 |
2012 |
rs1217691063
|
|
Carcinogenesis
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found that the effect of dietary methyl supply on colorectal carcinogenesis may differ according to MTHFR C677T genotype and the subsite of origin in a Korean population.
|
22218157 |
2012 |
rs1217691063
|
|
Carcinogenesis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, and the role of the MTHFR C677T polymorphism in pancreatic carcinogenesis is still controversial.
|
23098468 |
2012 |
rs1217691063
|
|
Carcinogenesis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, and the role of MTHFR C677T polymorphism in cervical carcinogenesis is still controversial.
|
22901193 |
2012 |
rs1217691063
|
|
Carcinogenesis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase gene (MTHFR) C677T polymorphism may be a risk factor for head and neck squamous cell carcinoma due to changes in folate levels that can induce disorders in the methylation pathway, which results in carcinogenesis.
|
21180947 |
2011 |
rs1217691063
|
|
Carcinogenesis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although MTHFR C677T was associated with increased risks of colorectal cancer, leukemia, and gastric cancer, our pooled data suggest no evidence for a major role of MTHFR C677T in the carcinogenesis of childhood acute lymphoblastic leukemia.
|
20409583 |
2010 |
rs1217691063
|
|
Carcinogenesis
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the polymorphism MTHFR C677T is clearly related to prostatic carcinogenesis, on the contrary to the other polymorphisms studied, although the MTR 2756 allele C acts as a factor of tumor aggressiveness, this being found in tumors with high carcinogenic potential.
|
17967524 |
2008 |
rs1217691063
|
|
Carcinogenesis
|
|
0.100 |
GeneticVariation
|
BEFREE |
To assess the association between the C to T transition in the methylenetetrahydro folate reductase gene (MTHFR C677T) and the C to T transition in the serine hydroxymethyltransferase ( 1 )gene (SHMT ( 1 ) C1420T) and the increased risk of carcinogenesis of esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA) in a population of high incident region of Northern China.
|
17206530 |
2007 |
rs1217691063
|
|
Carcinogenesis
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, there is no association of either the 677C-->T or 1298A-->C polymorphisms in cervical carcinogenesis.
|
16297972 |
2006 |
rs1217691063
|
|
Carcinogenesis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to examine the effect of MTHFR polymorphism C677T on cervical carcinogenesis in the context of other environmental factors, such as smoking, parity, and age at the first intercourse.
|
15581963 |
2004 |
rs1217691063
|
|
Carcinogenesis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the study was to investigate the role of MTHFR 677 C-->T gene polymorphism in the tumorigenesis of proximal and distal CLC in a monoinstitutional group of patients in North Italy.
|
12576444 |
2003 |
rs1217691063
|
|
Carcinogenesis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings support the hypothesis that MTHFR C677T variants contribute to gastric carcinogenesis, particularly in gastric cardia.
|
11494235 |
2001 |