rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Significant associations with BC were observed for rs3803662 (dominant comparison: OR, 0.89; 95% CI, 0.84-0.95; P = .0008; recessive comparison: OR, 1.17; 95% CI, 1.07-1.28; P = .0004; over-dominant comparison: OR, 1.07; 95% CI, 1.02-1.11; P = .002; allele comparison: OR, 0.90; 95% CI, 0.86-0.95; P = .0002), rs8051542 (dominant comparison: OR, 0.87; 95% CI, 0.83-0.91; P < .0001; recessive comparison: OR, 1.19; 95% CI, 1.11-1.28; P < .0001; over-dominant comparison: OR, 1.07; 95% CI, 1.02-1.11; P = .004; allele comparison: OR, 0.89; 95% CI, 0.86-0.91; P < .0001), and rs12922061 (dominant comparison: OR, 0.83; 95% CI, 0.73-0.93; P = .002; over-dominant comparison: OR, 1.43; 95% CI, 1.27-1.61; P < .0001) polymorphisms in the overall population.
|
31324582 |
2019 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
SNP rs3803662 (TOX3/TNRC9) is an independent prognostic factor for breast cancer in Henan Han Population.
|
31317673 |
2019 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
TOX3-rs3803662, may confer some degrees of risk of breast cancer in Iranian population.
|
30515698 |
2019 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested that TOX3 rs3803662 polymorphism was associated with increased breast cancer risk.
|
29578175 |
2018 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Given that <i>TOX3</i> mRNA is a target of miR-182, and that both the <i>TOX3</i> rs3803662-T and pri-miR-182 rs4541843-T alleles are associated with increased BC risk, we evaluated their combined effect.
|
30135399 |
2018 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
No statistically significant association was found between the rs3803662 polymorphism and breast cancer in patients or healthy controls.
|
29683073 |
2018 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
BC patients (n = 1687) randomly sampled in an adjuvant, randomized phase III trial (SUCCESS A study) were genotyped for nine BC risk SNPs: rs17468277 <i>(CASP8)</i> , rs2981582 <i>(FGFR2)</i> , rs13281615(8q24), rs3817198 <i>(LSP1)</i> , rs889312 <i>(MAP3K1)</i> , rs3803662 <i>(TOX3)</i> , rs13387042(2q35), rs4973768 <i>(SLC4A7)</i> , rs6504950 <i>(COX11)</i> .
|
28757652 |
2017 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The TNRC9 rs3803662 C>T polymorphism is greatly related to increased risk of BC, in both Asian and Caucasian populations.
|
27525937 |
2016 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A case‑control study (90‑100 cases; 90‑100 controls) was performed to evaluate five genetic variants of three genes, including FGFR2 (SNPs: rs1219648, rs2981582), TNRC9 (SNPs: rs8051542, rs3803662) and MAP3K1 (SNP: rs889312) as BC risk factors in Pakistani women.
|
27572905 |
2016 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Subjects carrying an allele of rs2981582 had reduced breast cancer risk (GA vs GG: OR=0.444, 95% CI=0.262-0.752; AA vs GG: OR=0.579, 95% CI=0.342-0.983). rs3803662 and rs3817198 SNPs did not significantly differ between cases and controls (P=0.408 and 0.116, respectively).
|
26911390 |
2016 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The present meta-analysis suggests that rs3803662 polymorphism is significantly associated with breast cancer risk in Caucasian women, and we did not find the association in Asian women.
|
27350156 |
2016 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Five common breast cancer susceptibility loci from GWAS are not strongly associated with breast cancer risk among the Han Chinese of the Henan province; only rs3803662 (T</span>OX3/TNRC9) is confirmed to increase the risk of breast cancer.
|
26803517 |
2016 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, we show that there is little overlap between the breast cancer risk single nucleotide polymorphisms (SNPs) identified so far and the SNPs associated with breast cancer prognosis, with the possible exceptions of LSP1-rs3817198 and TNRC9-rs3803662.
|
25611573 |
2015 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In Asian populations, there were significant associations of rs3803662</span> and rs8051542 with breast cancer risk.
|
26239137 |
2015 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
We conclude that SNP rs3803662 is a putative risk factor for breast cancer in Chinese Han women.
|
24446301 |
2014 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
These results indicate an additive effect of the TOX3 rs3803662 and 2q35 rs13387042 alleles for BC risk.
|
24532140 |
2014 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, genetic polymorphism (rs3803662C>T) in TOX3 was reported to induce the risk of breast cancer.
|
24069142 |
2013 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Ten of the 11 breast cancer susceptibility loci reported by consortia also showed associations in our predominantly Caucasian study population, and the associations were independent of BMI; four FGFR2 SNPs and TNRC9-rs3803662 were among the most notable associations.
|
23717390 |
2013 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Three SNPs were significantly associated with a breast cancer risk in multivariate analysis: rs2046210 (per allele OR=1.37 [95% CI: 1.11-1.70]), rs3757318 (OR=1.33[1.05-1.69]), and rs3803662 (OR=1.28 [1.07-1.55]).
|
24289300 |
2013 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
We confirmed associations between rs13387042 (2q35), rs4973768 (SLC4A7), rs10941679 (5p12), rs2981582 (FGFR2), rs3817198 (LSP1), rs3803662 (TOX3), and rs6504950 (STXBP4) with breast cancer.
|
23893088 |
2013 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
With the exception of rs3803662 (TOX3), there was no evidence that any of the SNPs associated with BC susceptibility were associated with the BC survival.
|
22532573 |
2012 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The results suggest that the effect of the risk allele of rs3803662 is strongest in luminal A tumours and that the expression levels of TOX3 and/or LOC643714 affect the progression of breast cancer.
|
23270421 |
2012 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The most strongly associated SNP was in intron 2 of the FGFR2 gene that is amplified and overexpressed in 5-10% of BC. rs3803662 of TNRC9 gene has been shown to be the SNP with the strongest association with BC, in particular, this polymorphism seems to be correlated with bone metastases and estrogen receptor positivity.
|
21996731 |
2012 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A dose-dependent association was observed between the risk of breast cancer and the genetic risk score, which was an aggregate measure of alleles in seven selected variants, namely FGFR2-rs2981579, TOX3/TNRC9-rs3803662, C6orf97-rs2046210, 8q24-rs13281615, SLC4A7-rs4973768, LSP1-rs38137198, and CASP8-rs10931936.
|
22160591 |
2012 |
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In the validation study using Stage I of the 2,273 cases and 2,052 controls, seven GWAS-identified loci [5q11.2/MAP3K1 (rs889312 and rs16886165), 5p15.2/ROPN1L (rs1092913), 5q12/MRPS30 (rs7716600), 6q25.1/ESR1 (rs2046210 and rs3734802), 8q24.21 (rs1562430), 10q26.13/FGFR2 (rs10736303), and 16q12.1/TOX3 (rs4784227 and rs3803662)] were significantly associated with breast cancer risk in Korean women (Ptrend < 0.05).
|
22452962 |
2012 |